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Nano-optodes with a diamond core coated with a double stimuli-responsive polymeric shell reversibly respond to pH and temperature changes.

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The miniaturized radiation camera MiniPIX TPX3 is designed for detailed and wide-range measurements of mixed-radiation fields present in many applications such as radiotherapy and space radiation in outer orbit. The highly integrated instrumentation utilizes a single connector for control and readout for flexible measurements and quick deployment. The device features an option to process the registered data on the same device with limited resolution and basic particle-type resolving power. A novel readout and data processing technique exploits the detector high granularity and double per-pixel signal electronics to measure and characterize radiation fields of high intensity over a wide range with basic particle-type discrimination.

DNA origami nanoframes with two parallel DNA sequences are used to evaluate the effect of nucleoside substituents on radiation-induced DNA damage. Double strand breaks (DSB) of DNA are counted using atomic force microscopy (AFM), and total number of lesions is evaluated using real-time polymerase chain reaction (RT-PCR). Enhanced AT or GC content does not increase the number of DNA strand breaks. Incorporation of 8bromoadenosine results in the highest enhancement in total number of lesions; however, the highest enhancement in DSB is observed for 2′-deoxy-2′-fluorocytidine, indicating different mechanisms of radiosensitization by nucleoside analogues with the halogen substituent on base or sugar moieties, respectively. "Bystander" effects are observed, when the number of DSB in a sequence is enhanced by a substituent in the parallel DNA sequence. The present approach eliminates limitations of previously developed methods and motivates detailed studies of poorly understood conformation or bystander effects in radiation induced damage to DNA.