Background: Left ventricular hypertrophy (LVH) is a preclinical manifestation of cardiovascular disease and a strong predictor of cardiovascular morbidity and mortality. The electrocardiogram (ECG) is an easily available, easy to use and cost effective tool to evaluate LVH. Peguero – Lo Presti criteria is a newcriteria to diagnose LVH from ECG that has higher sensitivity than the other ECG criteria.Aims: To assess the ability of Peguero – Lo Presti criteria to diagnose LVH and obtain new cut-off point criteria to more accurately diagnose LVH in patients with hypertension in Adam Malik Hospital.Methods: A cross sectional study was conducted on patients with hypertension in cardiac centre Adam Malik Hospital Medan. Electrocardiographic examination was performed to obtain Peguero – Lo Presti point in blinded fashion. LVH was assessed using M-mode method with Cube formula. The analysis of Peguero – Lo Presti criteria was based on the calculation of the deepest S wave in any precordial lead (deepest S wave,SD) and S wave in lead V4 (SV4). A SD + SV4 ≥ 28 mm in male and ≥ 23 mm in female subjects were considered positive for LVH. LVH was defined as left ventricular mass index > 115 gr/m2 in male and > 95 gr/m2 in female subjects.Results: Peguero – Lo Presti criteria had 54.8% sensitivity, 97.6% specificity, 55.4% NPV and 97.6% PPV to diagnose LVH. Lowering the cut-off point of Peguero – Lo Presti criteria to 26 mm in male and 22 mm in female subjects improved the sensitivity from 54.8% to 67.1% with 90.5% specificity, 61.3% NPV and 92.5% PPV to diagnose LVH.Conclusion: Peguero – Lo Presti criteria on ECG could be used to diagnose LVH in patients with hypertension in Adam Malik Hospital Medan.

Aging is an inevitable physiological process that must be experienced by every human being. This process is irreversible which includes all organs of the body including the skin. The skin is one of the tissues that will directly show the aging processes. Premature aging can happen to anyone. Especially in Indonesia, which is a tropical climate country with higher intensity sunlight. The degenerative process in skin that is too often exposed to ultraviolet light takes place more quickly to aging. Premature aging can happen to anyone. Especially in Indonesia, which is a tropical climate with higher intensity sunlight. The degenerative process in skin that is too often exposed to ultraviolet light takes place more quickl.

BACKGROUND: Cd (II) ion is a heavy metal that has a toxic ability in the human body. P. macrocarpa has been used as anticancer, Diabetes Mellitus and antimicrobe because it consists of flavonoid, steroid, and tannin. AIM: The purpose of this study was to investigate the effectiveness of P. macrocarpa fruits extract as an antidote for the toxicity of Cd (II) in the liver of experimental rats. METHODS: The experimental laboratory was done by using 9 female of Wistar rats (Rattus novergicus) that divided into 3 groups with the age between 2.5-3 months and weight between 133-160 grams. The first group was a control given distilled water and a normal diet. The second group was given antidote 5 mL of P. macrocarpa fruit extract x BW/200 g dosage for 7 days and induced by 1000 mg/L of Cd (II) ion with dosage of 1 mL x BW/200 g. The third group was given 1000 mg/L Cd (II) ion only of 1 mL x BW/200 g. After 5 hours, the blood sample was taken for analysis of MDA, SGOT, and SGPT. RESULTS: As the result of experimental rats exposed with Cd (II) ion, there are significant decreasing of all the observed parameters including MAD, SGOT and SGPT with percentage 71.5%, 72.1%, and 93.6% respectively. CONCLUSION: The rats given with the antidote of Phaleria macrocarpa flesh fruit were able to protect the liver from damage due to exposure to Cd (II) as seen from the decrease in liver function enzyme parameters namely SGOT and SGPT.

No abstract

Free radicals are one form of reactive oxygen compounds, which are generally known as compounds that have unpaired electrons. Kemangi leaves are used as an aphrodisiac because they contain araginin which can strengthen sperm resistance and prevent infertility. Besides araginin, Kemangi leaves also contain other secondary metabolites such as essential oils, phytosterols, alkaloids, phenolic compounds, tannins, lignin, saponins, flavonoids, terpenoids and anthraquinones. Phytochemical screening results of 70% ethanol extract of kemangi herbs themselves showed the presence of secondary metabolites of flavonoids, saponins, tannins and triterpenoids / steroids. In this study, antioxidant activity was tested using the FRAP (Ferric Reducing Antioxidant Power) method, with concentrations of kemangi leaf extract and comparative compounds Euginol each concentration of 1000 μL/ml, 5000 μL/ml, 250 μL/ml, and 125 μL/ml, 62.50 μL/ml, and 31.25 μL/ml measured at 745 nm wavelength and collagenase inhibition test with ethanol extract of kemangi leaves with a comparison of eugenol compounds measured at a wavelength of 335 nm. The FRAP antioxidant activity results obtained based on IC50 Eugenol value of 261.36 μg/ml and Kemangi leaf extract at 111.32 μg/ml, antolagenagenase from Eugenol at 255.32 μg/ml and Kemangi leaf extract at 110.65 μ/ml.

Dari hasil laporan Komite Keselamatan Pasien Rumah Sakit Royal Prima Jambi salah satu penyebab terjadinya KTD adalah salah identifikasi yang dilakukan oleh petugas kesehatan rumah sakit. Data insiden keselamatan pasien tahun 2017 melaporkan analisis penyebab terjadinya insiden kesalahan dalam pemberian obat dikarenakan komunikasi tidak efektif sehingga terjadi medication error, selain itu juga dikarenakan prosedur tidak dijalankan dengan benar. Untuk mengindari kesalahan dalam identifikasi pasien maka sangat diperlukan gelang identitas pasien yang dibutuhkan untuk membantu mengidentifikasi pasien. Setiap pasien dirumah sakit berhak diidentifikasi secara benar. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi perilaku perawat dalam rangka penerapan pasien safety di Rawat Inap Rumah Sakit Royal Prima Jambi Tahun 2018. Jenis penelitian ini adalah cross sectional. Sampel dalam penelitian ini adalah perawat di ruang keperawatan Bougenvillle, Crysant, Edelweis dan Aster sebanyak 51 responden. Data dianalisis dengan menggunakan Chi-Squere dan Regresi Logistik. Hasil penelitian menunjukkan ada pengaruh yang signifikan antara pengetahuan (p – value = 0,008), sikap (p – value = 0,000), fasilitas (p – value = 0,000), dan pengalaman kerja (p – value = 0,002) terhadap perilaku  perawat dalam rangka penerapan pasien safety di Rawat Inap Rumah Sakit Royal Prima Jambi Tahun 2018  . Dan setelah melakukan uji logistic berganda dari 3 model didapatkan bahwa faktor yang paling dominan berpengaruh terhadap perilaku  perawat dalam rangka pasien safety adalah sikap dengan nilai exponen B 87.535 dengan nilai p = 0,001.

Background: Acute Coronary Syndrome (ACS) is a term used to describe symptoms caused by Acute Myocardial Infarction (AMI). At present, risk stratification is carried out with the use of a Global Registry of Acute Coronary Events (GRACE) score as a validated predictor for cardiovascular events among ACS patients. Mean platelet volume (MPV) is an accurate marker of platelet size and can be considered that to be added to the GRACE score to increase the predictive value of the occurrence of major cardiovascular events (MACE). This study aims to seek the comparison between GRACE score independently and GRACE score with the addition of MPV values in predicting major cardiovascular events during in-hospital care in ACS patients. Methods: This study was ambispective cohort study of 219 ACS patients from November 2017 to November 2018. GRACE scores and MPV values were calculated and mace was observed during hospital treatment. An analysis was performed to see the role of MPV addition to GRACE scores in predicting MACE. Results: MPV values and GRACE scores were found to be increased in patients with MACE compared with those who did not. Area under curve (AUC) on the ROC curve obtained 0.786 (95% CI: 0.717-0.855, p<0.001) when the GRACE score was calculated independently, and increased to 0.810 (95% CI: 0.620-0.775, p<0.001) with addition MPV which indicates a combination of MPV and GRACE score increases predictive value. Conclusion: The addition of the MPV value to the GRACE score provides a higher predictive value in predicting MACE in ACS patients in hospital care.

Harm effect from UV light, both UV-A and UV-B is contributing as a disease trigger and has an impact on human health. To investigate the bioactive compound, antioxidant, and the potential of basil leaves as antiaging sources particularly as the tyrosinase inhibitor. This study used phytochemical screening for the bioactive compound, DPPH scavenging activity for antioxidant assay, and tyrosinase inhibition activity for the antiaging property. The phytochemical screening shows that the basil leaves extract has flavonoid, saponin, phenol, steroid, and alkaloid. The basil leaves extract has lower antioxidant activity (20.55 ± 0.04 μg/mL) compared with eugenol (2.44 ± 0.26 μg/mL) through DPPH scavenging activity. The basil leaves extract (35.59 ± 0.83 μg/mL) has lower antiaging activity particularly as antityrosinase activity compared with eugenol (10.87 ± 0.41 μg/mL). Our findings suggest that basil leaves can be used as an antioxidant and antiaging source, particularly as a tyrosinase inhibitor.