Antioxidant Activities of Black Soybean Extract (Glycine max (L.) Merr.) and Daidzein as Hydroxyl and Nitric Oxide Scavengers

Irwan, Mulia; Girsang, Ermi; Nasution, Ali Napiah; Lister, I Nyoman Ehrich; Amalia, Annisa; Widowati, Wahyu

doi:10.15395/mkb.v52n2.1816

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…This previous research was confirmed by decreasing levels of pro-inflammatory cytokines in serum and lung by PGE treatment in an ARDS rats model [32]. Daidzin and genistin 40, 200 µg/mL act as anti-inflammatory by downregulating PGE2, IL-1β, and TNF-α levels in LPS-stimulated macrophage cells [33].…”

Section: Discussionmentioning

confidence: 55%

Guava (Psidium guajava L.) extract inhibits cytokine storm in acute respiratory distress syndrome rats model

PRIYANDOKO,

WIDOWATI,

NOVIANTO

et al. 2024

jrp

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COVID-19 infection is always accompanied by a cytokine storm that causes acute respiratory distress syndrome (ARDS). The reduction of pro-inflammatory cytokines is expected to be used for treating COVID-19 patients. Guava (Psidium guajava L.) was believed to have properties as an antioxidant and anti-inflammatory. This study aims to determine the effect of guava extract (PGE) on the ARDS rats model so that it can be used as a PGE treatment for the effects caused by ARDS. This study was conducted on 25 Sprague Dawley rats model in 5 treatment groups. Lipopolysaccharides (LPS) induction was carried out to create ARDS rats model. Determination of pro-inflammatory cytokines in lung Interleukin-18 (IL-18), IL-12 and serum IL-1β, Tumour Necrosis Factor alpha (TNF-α) was performed by ELISA, NOD-, LRR-and Pyrin domain-containing protein 3 (NRLP3) expressions were determined by the quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) method and IL-6, Nuclear factor kappa B (NF-κB) were analysed by immunohisto-chemistry assay. The results showed that PGE contained phenolic compound, daidzin and genistin. The IL-18, IL-12, Il-1β, TNF-α, IL-6, NF-kB and NRLP3 in ARDS model rats were decreased by PGE treatment. In conclusion, PGE can be used as a therapy for treating ARDS by decreasing pro-inflammatory marker.

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Section: Discussionmentioning

confidence: 55%

Guava (Psidium guajava L.) extract inhibits cytokine storm in acute respiratory distress syndrome rats model

PRIYANDOKO,

WIDOWATI,

NOVIANTO

et al. 2024

jrp

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“…A compound's antioxidant activity is more potent when its IC50 value is smaller. A compound is categorized as a powerful antioxidant if the IC50 < 50 µg/mL, strong 50-100 µg/mL, moderate 100-500 µg/mL, and weak > 500 µg/mL (Irwan, 2020;Widowati et al, 2017;Jusri et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The antioxidant and anti-elastase activities of tamarillo fruit extract (Solanum betaceum)

Fioni,

Liena,

Siregar

et al. 2023

jika

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Skin aging is a complex process characterized by structural and functional loss of skin tissue. Aging is triggered by reactive oxidative stress (ROS), which activates enzymes involved in the aging process, such as elastase. Tamarillo is one of the natural plants that has various chemical compounds that have the potential to be antioxidants and anti-aging. The objective was to examine the antioxidant and antiaging activity of Tamarillo Fruit Extract (TFE). The H2O2 scavenging assay and anti-elastase assay were used. The result shows that TFE has a high antioxidant activity, as evaluated by H2O2 scavenging activity. The highest scavenging activity was found in a TFE concentration of 500 µg/mL (72.96%). Meanwhile, TFE shows its highest anti-elastase activity at a concentration of 66.67 µg/mL (32.33%). TFE's activity in both antioxidant and antiaging assays was concentration-dependent. The IC50 of the H2O2 assay was 278.20 µg/mL, and the IC50 of the anti-elastase assay was 110.67 µg/mL. Therefore, TFE shows its antioxidant and antiaging activities and has the potential to be used in further studies, both in vivo and clinical studies.

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“…Soybeans, as one of the most common foodborne biomaterials, have attracted attention for enhanced skin healing. Their abundant soybean protein can be used as an alternative peptide mimetic in human extracellular matrix (ECM) to promote cell adhesion, proliferation, and migration, which is essential for cutaneous wound healing. ,− Therefore, soybean protein, which has been studied extensively, has displayed excellent characteristics in hydrogels, films, and adhesives used in tissue engineering − In addition, soybeans are rich in soybean oil (unsaturated fatty acids and tocopherols), isoflavone, saponin, and other bioactive components, which are closely related to the antioxidant properties essential to resist redox imbalance of the wound bed microenvironment. − For example, soybean-derived tofu bioscaffolds have been studied for their antioxidant effect on skin wounds. − …”

Section: Introductionmentioning

confidence: 99%

Natural Soybean Milk-Derived Bioactive Coatings for Enhanced Wound Healing

Xin

Han

Huang

et al. 2022

ACS Appl. Mater. Interfaces

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Foodborne biomaterials, derived from diets, comprise selfassembled collections of many micro-or nanoscale units with abundant nutrients and active substances. In this study, soybean milk (SBM) was selected as a tissue engineering product for simple and feasible wound repair. SBM is a common drink prepared from soybeans and is rich in soy protein, soy isoflavones, and other bioactive components. Thus, SBM has substantial potential for antioxidation and tissue remodeling. Here, the multifunctional effect of SBM as a bioactive coating for promoting wound healing was studied. The results showed that SBM has good biocompatibility and biological activity. It efficiently scavenges intracellular reactive oxygen species, significantly enhances epithelial cell migration, and improves angiogenesis, thereby accelerating tissue remodeling. The results of animal experiments further confirmed that the SBM-bioinspired coating has promising applications for cutaneous wound regeneration.

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Antioxidant Activities of Black Soybean Extract (Glycine max (L.) Merr.) and Daidzein as Hydroxyl and Nitric Oxide Scavengers

Cited by 4 publications

References 7 publications

Guava (Psidium guajava L.) extract inhibits cytokine storm in acute respiratory distress syndrome rats model

Guava (Psidium guajava L.) extract inhibits cytokine storm in acute respiratory distress syndrome rats model

The antioxidant and anti-elastase activities of tamarillo fruit extract (Solanum betaceum)

Natural Soybean Milk-Derived Bioactive Coatings for Enhanced Wound Healing

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