Thiol disulphide homeostasis in patients with basal cell carcinoma alters in the way that disulphide gets lower and thiols get higher. Thiol/disulphide level is likely to have a role in basal cell carcinoma pathogenesis.

Thiol/disulfide balance shifted towards thiol in psoriasis patients and this may be responsible for increased keratinocyte proliferation in the pathogenesis of psoriasis.

In rosacea patients, the thiol/disulfide balance was observed to shift towards disulfides, which could be considered an indicator of oxidative stress in rosacea.

Thiol-disulphide balance was not affected by AU but shifted towards to disulphide in CSU indicating the presence of oxidative stress (OS).

Objective: Dermatomycosis is an infection with fungi related to the skin: glabrous skin, hair and/or nails. Oral treatment of fungal infections in dermatology has become a preferred modality for the management of these very common conditions. Although there are increasing numbers of antifungals available for treatment of dermatophytes, some cases and relapses have been unresponsive to treatment. The determination of fungus in-vitro antifungal susceptibility has been reported to be important for the ability to eradicate dermatophytes. It is necessary to perform antifungal susceptibility testing of dermatophytes. E-test (AB Biodisk, Sweden) is a rapid, easy-toperform in-vitro antifungal susceptibility test. The aim of this study was to investigate the susceptibility of the different species of dermatophyte strains isolated clinical specimens to five antifungal agents using the E-test method. Materials and Methods:A total of 66 specimens were collected from the nails, feet, inguinal region, trunk and hands. These strains tested MIC endpoints of E-test for amphotericin B, fluconazole, itraconazole, caspofungin, and ketoconazole were read after 72, and 96 hours incubation for each strain on RPMI 1640 agar. Results:The dermatophytes tested included Trichophyton rubrum 43 (65.1%), Trichophyton mentagrophytes 7 (10.7%), Microsporum canis 5 (7.6%), Trichophyton tonsurans 5 (7.6%), Epidermophyton floccosum 4 (6.0%) and Trichophyton violaceum 2 (3.0%). The most active agent against all dermatophytes species was caspofungin with a minimal inhibitory concentration (MIC) range (μg/mL ) (0, 19-48, 2-256, 2-8, 256, 256, 8-24).Conclusion: E-test seems to be an alternative method to MIC-determination of antifungal drugs for dermatophytes species, since it is a less-laborious methodology and results could be obtained faster. Key Words: Dermatophytes, E-test, antifungal ÖzetAmaç: Dermatomikozlar mantarlar tarafından oluşturulan deri, saç ve tırnakları tutan enfeksiyonlardır. Dermatolojide mantar enfeksiyonlarının oral tedavisi yaygın olarak tercih edilen yöntem haline gelmiştir. Dermatofitlerin tedavisi için kullanılan antifungallerin sayısının artmasına rağmen bazı durumlarda tedaviye yanıtsızlık ve nüksler gelişmektedir. İn-vitro antifungal duyarlılığın belirlenmesinin dermatofitlerin etkili olarak tedavi edilmesi için önemli olduğu bildirilmektedir. Antifungal duyarlılığın belirlenmesinde yöntemler önemlidir. E-test (AB Biodisk, İsveç) hızlı ve kolay uygulanabilir bir duyarlılık yöntemidir. Bu çalışmanın amacı, klinik örneklerden izole edilen farklı dermatofit türlerinin beş antifungal ilaca karşı duyarlılık-larını E-test yöntemi ile belirlemektir. ) aralıkları ile itrakonazol olarak bulundu. En az etkili antifungal ise (0, 19-48, 2-256, 2-8, 256, 256, 8-24) MIC (μg/mL -1 ) aralıkları ile flukonazol olarak bulundu. Gereç veSonuç: E-test dermatofit türlerinin antifungal duyarlılığının belirlenmesinde daha az zahmetli ve sonuçların daha hızlı elde edilebilir olması ile alternatif bir yöntem gibi görünmektedir.

Interpretation of the data; critical review of the literature; critical review of the manuscript. Akın Aktaş: Interpretation of the data; critical review of the literature; critical review of the manuscript.

Folliculitis decalvans is a rare and chronic progressive hair disorder leading to scarring alopecia and atrophy. Its etiology is still unclear. It starts with areas of perifollicular erythema, and follicular papules and pustules spread peripherally, leaving central scarred patches of alopecia. We report a 27-year-old man who presented with folliculitis decalvans involving the scalp, face, nape, and beard. There were pustules, crusts, and scarring alopecia on the scalp and beard.

We provide evidence that that thiol/disulphide homeostasis impaired in favor of thiol levels in LP patients compared to the control group based on the data of our study. To the best of our knowledge, the present study is the first examination on the correlation between thiol and disulfide homeostasis in patients with LP.