In rosacea patients, the thiol/disulfide balance was observed to shift towards disulfides, which could be considered an indicator of oxidative stress in rosacea.

Thiol-disulphide balance was not affected by AU but shifted towards to disulphide in CSU indicating the presence of oxidative stress (OS).

A systemic oxidative stress exists in patients with vitiligo. These results indicate that the global antioxidant capacity of patients might have been exhausted through a defence mechanism against oxidative processes. The imbalance in TOS/TAS status may have an important role in the aetiopathogenesis of vitiligo, regardless of the clinical variant of the disease.

BackgroundRecurrent aphthous stomatitis (RAS) is a chronic relapsing inflammatory disorder of the oral mucosa with unknown etiology. Oxidative stress (OS) is suggested to play a main role in the etiopathogenesis in RAS.ObjectiveIn this study, we hypothesize that a systemic OS is present in patients with RAS.MethodsForty-four patients with active RAS lesions and 38 healthy controls were being included in the study. Serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase 1 arylesterase (ARES) activity were being determined.ResultsRAS patients had significantly lower TAS levels and higher TOS and OSI values than controls. The patients had a lower ARES activity when compared to healthy controls. No correlations were observed between OS parameters and age, gender, duration of disease or frequency of RAS attacks per month.ConclusionA systemic OS is determined with an imbalance in oxidant/antioxidant status and lower ARES activity in RAS. Systemic OS may have an important role in the pathogenesis of RAS formation.

Seborrheic dermatitis (SD) is a chronic superficial disease that is more common in 3%-5% of the population (2.35%-11.3%) especially in men. It is frequently involved in skin folds such as the scalp, eyebrows, eyelids, nasolabial region, ear, sternal region, axilla, under the breasts, navel, and inguinal region. It is common in the infantile and adolescence period, increases after the age of 50. 1,2 The most accused in its etiopathogenesis can be listed as seborrhea, microbial factors such as malassezia, candida, immunological disorders such as demodex parasite, androgenic hormones, HIV carrier, drugs, nutritional disorders, hereditary factors, atopy, physical factors such as UV and sun, lifestyle, stress. Various neurological diseases such as Parkinson's can be seen together with SD. [3][4][5] Skin diseases such as psoriasis, atopic dermatitis, acne, and rosacea are also frequently associated with SD. 3 Its etiopathogenesis is not fully elucidated, and it is thought to be an abnormal local inflammatory immune response due to malessezia species and their potential metabolites. 1,2

IntroductionTinea versicolor is a superficial fungal infection caused by Malassezia spp. Malassezia spp. is a member of the normal human skin flora. It becomes a pathogen by transforming from the yeast form to the mycelium form. The oxidant/antioxidant homeostasis may be responsible for this. Thiol/disulphide homeostasis is a new marker indicating oxidative stress. This homeostasis is affected in many illnesses.AimTo investigate the thiol/disulphide homeostasis in patients with tinea versicolor.Material and methodsForty-two patients with tinea versicolor (median age: 36 years, min.–max.: 19–58) and 36 healthy controls (median age: 32 years, min.–max.: 18–60) were included in the trial. The levels of native thiol, disulphide, and total thiol were measured by an automated method in the patient and control groups. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol rates were calculated as percentage.ResultsFor the patient group and the control group, the native thiol levels were found to be 464.32 ±51.48 mmol/l and 465.18 ±51.32 mmol/l, disulphide levels – 19.80 ±7.08 mmol/l and 21.27 ±8.90 mmol/l, total thiol levels – 503.92 ±53.65 mmol/l and 508.07 ±56.59 mmol/l, respectively. No statistical difference was detected between the two groups.ConclusionsThiol/disulphide homeostasis was not affected in tinea versicolor. According to our findings, oxidative stress seems to have no role in the pathogenesis of tinea versicolor.

Localized scleroderma (LS) (morphea) is a chronic, inflammatory skin disease with unknown cause that progresses with sclerosis in the skin and/or subcutaneous tissues. Its pathogenesis is not completely understood. Oxidative stress is suggested to have a role in the pathogenesis of localized scleroderma. We have aimed to determine the relationship of morphea lesions with oxidative stress. The total oxidant capacity (TOC), total antioxidant capacity (TAC), paroxonase (PON) and arylesterase (ARES) activity parameters of PON 1 enzyme levels in the serum were investigated in 13 LS patients (generalized and plaque type) and 13 healthy controls. TOC values of the patient group were found higher than the TOC values of the control group (p < 0.01). ARES values of the patient group was found to be higher than the control group (p < 0.0001). OSI was significantly higher in the patient group when compared to the control (p < 0.005). Oxidative stress seems to be effective in the pathogenesis. ARES levels have increased in morphea patients regarding to the oxidative stress and its reduction. Further controlled studies are required in wider series.

Background: Thiols are antioxidant, organic compounds containing sulfhydryl group on their active sites. They have important roles on preventing oxidative stress. The thiol disulfide homeostasis has a vital importance in organism. Thiol disulfide imbalance is an early indicator of oxidative stress. Alopecia areata is an autoimmune skin disorder characterized with scar-free hair loss. Its pathogenesis is still unclear. Thiol disulfide homeostasis in these patients has not been studied at all. Objective: To evaluate the thiol disulfide homeostasis in alopecia areata patients and healthy controls. Methods: Fortysix alopecia areata patients and 41 healty controls were included in the study. Native thiol, disulfide, total thiol levels were performed with a new and automatic spectrophotometric method. Rations of disulfide/total thiol, disulfide/ native thiol and native thiol/ total thiol were calculated as percentages.