Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients

Kılınç, Fadime; Şener, Sertaç; Akbaş, Ayşe; Neşeli̇oğlu, Salim; Erel, Özcan; Aktaş, Akın

doi:10.9734/bjmmr/2017/33535

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…Knowing the function of thiols involved in the antioxidant system is therefore becoming increasingly important in terms of understanding several diseases associated with oxidative stress, including COPD [19]. Studies investigating the relation between oxidative stress and TDH have shown that such homeostasis is impaired in oxidative terms in patients with acute myocardial infarction, migraine, alopecia or chronic urticaria, in pregnant women with hyperemesis gravidarum (compared to normal gravidas), and in workers exposed to polycyclic aromatic hydrocarbons [14][15][16][33][34][35]. Babaoglu et al [36] assumed the presence of oxidative stress in COPD and investigated TDH in other subgroup diseases causing lower airway obstruction, such as asthma and asthma-COPD overlap syndrome (ACOS).…”

Section: Discussionmentioning

confidence: 99%

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Eroğlu

Badem

Baççıoğlu

et al. 2019

The European Research Journal

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Objectives: The severity of inflammation occurring during chronic obstructive pulmonary disease (COPD) is closely associated with oxidative stress. The aim of this study was to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD patients. Methods: This prospective study was performed with COPD patients presenting to the Kırıkkale University Hospital and with healthy volunteers. Subjects' demographic data (age, sex, body mass index, and smoking status), native thiol (NT), total thiol (TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were recorded. Statistical analysis was performed with SPSS 21.0 software. Results: One hundred ninety subjects were enrolled in the study, 141 COPD patients and 49 healthy volunteers. No difference was determined between the patient and control groups in terms of age, sex or body mass index. The antioxidant markers; NT and TT levels and NT/TT ratio were significantly lower in the patient group compared to the control group (p < 0.001, p < 0.001, and p < 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT ratios were significantly higher in the patient group (p = 0.006, p = 0.003, and p = 0.003, respectively). Significant negative correlation was determined between antioxidant and oxidant parameters. Sensitivity values were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA: 77.8%. Conclusions: TDH was impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used to monitor oxidative stress emerging in COPD.

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Section: Discussionmentioning

confidence: 99%

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Eroğlu

Badem

Baççıoğlu

et al. 2019

The European Research Journal

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“…It has been demonstrated that TDH was no changed in patients with alopecia areata, an autoimmune disease characterized scar-free hair loss. This may result from patients which has mild alopecia areata disease [75].…”

Section: Dermatologic Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…Kilinc et al (21) reported that the disulfide/native thiol and native thiol/total thiol ratios and native thiol, total thiol, and disulfide values were similar in AA patients and the control group. Akbas et al (8) reported that disulphide/thiol ratio increased in chronic urticaria and increased oxidative stress reduced disulphide ratio in chronic stage.…”

Section: Discussionmentioning

confidence: 97%

“…Kilinc et al (21) reported that thiol/disulfide values were not associated with gender, disease duration, number of lesions, or recurrence frequency in AA patients. Akar et al (18) reported that oxidation was augmented in the acute stage compared to the chronic stage.…”

Section: Discussionmentioning

confidence: 99%

A Marker for Evaluation of Oxidative Stress in Patients with Alopecia Areta: Thiol-Disulphide Homeostasis

Pektaş¹,

Alataş²,

Doğan³

et al. 2018

meandros

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Objective: Alopecia areata (AA) is a disorder characterized by non-scarring hair loss, whose etiology involves oxidative stress. We aimed to determine the role of thiol/disulphide levels in AA pathogenesis and to investigate if they can be used as its marker. Materials and Methods: This prospective study included 100 AA patients who presented to dermatology outpatient clinic and 100 healthy controls without any systemic and/or inflammatory dermatological disorder. The control and study groups were compared with respect to native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios. The relationships between demographic and lesion characteristics, native thiol, total thiol, and disulphide levels, and disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol ratios were studied. Results: The mean age of AA patients was 37.5 years. Fifty-eight (58%) patients were male, and the median body mass index was 24 kg/m 2. Median age was significantly higher in the AA group (p<0.05). The AA group had a significantly lower total and native thiol level, native thiol/total thiol ratio, significantly higher disulphide level, disulphide/native thiol ratio, and disulphide/total thiol ratio (p<0.05 for all comparisons). There was no correlation between the parameters of thiol/disulfide hemostasis and demographic and lesion characteristics (p>0.05). Conclusion: The thiol/disulphide homeostasis shifted towards oxidative stress, and a decrease in thiols and an increase in disulphides were found in the AA patients. This finding may be responsible for diffuse destruction of hair follicle in the pathogenesis of AA. Amaç: Alopesi areata (AA) etiyolojisinde oksidatif stresin rol aldığı, skarsız kıl kaybı ile karakterize bir hastalıktır. AA hastalarında tiyol/disülfid düzeylerine bakarak AA patogenezindeki rolünü ve AA patogenezinde bir belirteç göstergesi olup olmayacağının araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu kesitsel çalışma 27.07.2016-01.02.2017 tarihleri arasında dermatoloji polikliniğine başvuran AA tanısı alan 100 hasta ve herhangi bir sistemik ve/veya enflamatuvar deri hastalığı olmayan 100 gönüllü kontrol grubunda

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Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients

Cited by 7 publications

References 24 publications

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

A Marker for Evaluation of Oxidative Stress in Patients with Alopecia Areta: Thiol-Disulphide Homeostasis

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