BackgroundCutaneous leishmaniasis (CL) is a vector-mediated skin disease, characterized by chronic wounds on the skin and caused by macrophages in protozoan parasites. It is an endemic disease in the southern and southeastern Anatolia region and is still an important public health problem in Turkey. Because of the civil war in Syria, immigrants to this region in the last 3 years have begun to more frequently present with this disease. The aim of this study was to draw attention to the dramatic increase in new cases with CL after the beginning of the civil war in Syria.Material/MethodsIn this retrospective study, we evaluated demographic, epidemiological, and clinical features of 110 patients diagnosed with cutaneous leishmaniasis who were admitted to the Department of Dermatology at Kahramanmaras Sutcu Imam University Faculty of Medicine between January 2011 and June 2014.ResultsA total of 110 patients included in the study; 50 (45%) were males, and 60 (55%) were females. The age range of the study group was 1–78 years, and the infection was more prevalent in the 0–20 year age group. Of these patients, 76 (69%) were Syrian refugees living in tent camps and 34 (31%) were Turkish citizens. The majority of the cases were diagnosed between October and December.ConclusionsImmigrations to endemic regions of Turkey from neighbouring countries where CL incidence is higher may lead to large increases in case numbers. In order to decrease the risk of exposure, housing conditions of the refugees must be improved, routine health controls must be performed, effective measures must be set in place for vector control, and infected individuals must be diagnosed and treated to prevent spread of the infection.
Background In recent studies, microRNAs (mi-RNAs) have been shown to play an important role in psoriasis pathogenesis. However, studies evaluating mi-RNAs in the blood of psoriasis patients including a large number of mi-RNA panels are scarce. Objective The authors aimed to assess mi-RNA expressions in blood samples of psoriasis patients, as well as to evaluate the association between mi-RNA expression and psoriasis severity. Methods This was a case-control study on 52 patients with psoriasis vulgaris and 54 controls. Patients’ medical history, psoriasis area and severity index (PASI) scores, and dermatology life quality index (DLQI) scores were recorded. The 42 disease-related mi-RNA primers were assessed by real-time PCR. Results In the patient group, 13.4% presented nail involvement and 8.2% had psoriatic arthritis. The mean PASI and DLQI scores were 7.90 ± 8.83 and 8.13 ± 5.50, respectively. Among 42 mi-RNA primers; hsa-miR-155-5p, hsa-miR-369-3p, hsa-miR-193b-3p, hsa-miR-498, hsa-miR-1266-5p, hsa-let-7d-5p, hsa-miR-205-5p, hsa-let-7c-5p, hsa-miR-30b-3p, and hsa-miR-515-3p expressions were significantly up-regulated, whereas hsa-miR-21-5p, hsa-miR-142-3p, hsa-miR-424-5p, hsa-miR-223-3p, hsa-miR-26a-5p, hsa-miR-106b-5p, hsa-miR-126-5p, hsa-miR-181a-5p, hsa-miR-222-3p, hsa-miR-22-3p, hsa-miR-24-3p, hsa-miR-17-3p, hsa-miR-30b-5p, hsa-miR-130a-3p, hsa-miR-30e-5p, and hsa-miR-16-5p were significantly down-regulated in psoriasis patients when compared with the control group ( p < 0.05). Study limitations As the study included patients with mild to moderate psoriasis who mostly only received topical treatments, changes in miRNA before and after systemic treatments were not assessed. Conclusion The detection of 24 mi-RNA expressions up- or down-regulated in psoriasis patients, even in those with milder disease, further supports the role of mi-RNAs in the psoriasis pathogenesis. Future studies should clarify whether mi-RNAs can be used as a marker for psoriasis prognosis or as a therapeutic agent in the treatment of psoriasis.
Urticaria is a disease which progresses with itchy papules and plaques called urtica, obstructive sleep apnea syndrome (OSAS) is defined as daytime sleepiness and obstructive apnea and hypopnea attacks during sleep. In this study, we aimed to investigate the relationship between urticaria and OSAS. Thirty-one patients with chronic idiopathic urticaria were included in the study. Body mass indexes (BMIs) were calculated and polysomnography findings were recorded. Epworth Sleepiness
Introduction: Terra Firma-Forme Dermatosis (TFFD) is a little-known dermatosis. The etiology is not fully known. We aimed to investigate the clinical characteristics of TFFD, accompanying diseases, and a possible connection to allergic diseases. Material and Method: A total of 869 pediatric patients were examined within the study period. Forty-one patients (2.19%) diagnosed with TFFD were included in the study. Age, gender, medical history, family history of the patients, anatomic localizations of the lesions, time that the complaints were noticed, complaints on admission, accompanying diagnoses, laboratory tests, and total IgE levels were evaluated.Results: Truncal involvement was the most observed area in patients. At least one allergic disease was detected in 29 (70.7%) patients. The difference between the allergy ratio in the patients who were admitted to the outpatient clinic (0.107) and the patients with TFFD (0.707) was found statistically significant (t-value=8,345, P = 0.000). Total IgE levels were found to be high in 15 (55.5%) of 27 (65.85%) patients in whom the total IgE level was examined. In March-August, when allergic patients applied more frequently to the clinic, also cases with TFFD were seen more frequently. Conclusion:Our study suggests that TFFD may be a finding associated with allergic diseases, considering the seasonal distribution of the disease, concurrence with allergic diseases, and high IgE levels. ÖZETAmaç: Terra Firma-Forme Dermatozu (TFFD) az bilinen bir dermatozdur. Etiyolojisi tam olarak bilinmemektedir. TFFD'nun klinik özelliklerini, eşlik eden hastalıkları ve alerjik hastalıklarla olası bir bağlantıyı araştırmayı amaçladık. Gereç veYöntem: Çalışma sırasında toplam 869 pediatrik hasta muayene edildi. TFFD tanısı konmuş 41 hasta (% 2.19) çalışmaya dahil edildi. Hastaların yaşı, cinsiyeti, tıbbi öyküsü, aile öyküsü, lezyonların anatomik lokalizasyonları, fark edilme zamanı, başvuru şikayetleri, eşlik eden tanılar, laboratuar testleri ve total IgE düzeyleri değerlendirildi. Bulgular: Trunkal tutulum hastalarda en çok gözlenen alandı. 29 hastada (% 70.7) en az bir allerjik hastalık tespit edildi. Polikliniğe başvuran hastalar (0.107) ile TFFD'lu (0.707) hastalar arasındaki allerji oranı farkı istatistiksel olarak anlamlı bulundu (t-değeri = 8,345, P = 0.000). Total IgE düzeyleri incelenen 27 (% 65.85) hastanın 15'inde (% 55.5) yüksek bulundu. Alerjik hastaların kliniğe daha sık başvurdukları Mart-Ağustos aylarında TFFD'lu vakalar da daha sık görüldü. Sonuç: Çalışmamız, TFFD'nun mevsimsel dağılımı, alerjik hastalıklarla eşzamanlılığı ve yüksek IgE düzeylerini dikkate alarak alerjik hastalıklarla ilişkili bir bulgu olabileceğini düşündürmektedir.
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