The effect of tinea versicolor on thiol/disulphide homeostasis

Abstract

IntroductionTinea versicolor is a superficial fungal infection caused by Malassezia spp. Malassezia spp. is a member of the normal human skin flora. It becomes a pathogen by transforming from the yeast form to the mycelium form. The oxidant/antioxidant homeostasis may be responsible for this. Thiol/disulphide homeostasis is a new marker indicating oxidative stress. This homeostasis is affected in many illnesses.AimTo investigate the thiol/disulphide homeostasis in patients with tinea versicolor.Material and methodsForty-two patients with tinea versicolor (median age: 36 years, min.–max.: 19–58) and 36 healthy controls (median age: 32 years, min.–max.: 18–60) were included in the trial. The levels of native thiol, disulphide, and total thiol were measured by an automated method in the patient and control groups. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol rates were calculated as percentage.ResultsFor the patient group and the control group, the native thiol levels were found to be 464.32 ±51.48 mmol/l and 465.18 ±51.32 mmol/l, disulphide levels – 19.80 ±7.08 mmol/l and 21.27 ±8.90 mmol/l, total thiol levels – 503.92 ±53.65 mmol/l and 508.07 ±56.59 mmol/l, respectively. No statistical difference was detected between the two groups.ConclusionsThiol/disulphide homeostasis was not affected in tinea versicolor. According to our findings, oxidative stress seems to have no role in the pathogenesis of tinea versicolor.

Dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis

“…In many different clinical conditions, TDH was examined to show the severity of oxidative stress and significant results were found [18][19][20][21][22][23]. In our study, it was found that total thiol and native thiol levels were significantly lower in DKA.…”

The role of oxidative stress in onychomycosis: Thiol/disulphide homeostasis

“…Oxidative stress has been the subject of many studies focussing on various conditions including cutaneous disorders. [4][5][6][7][8][9][10] The dynamic balance of thiol/disulphide, a new indicator of oxidative stress,…”

“…21 However, Kilinç et al have failed to reveal significant changes in thiol-disulphide haemostasis in patients with the same condition. 4 Onychomycosis may be associated with several predisposing factors including diabetes, immunosuppression, psoriasis, obesity, advanced age and smoking. [22][23][24] Ateş et al have found higher levels of disulphide, disulphide/native thiol, and disulphide/total thiol, and lower levels of native thiol and total thiol in patients with type 1 diabetes mellitus compared to healthy controls.…”

“…Thiol/disulphide homeostasis was measured via an automated spectrometric technique suggested by Erel and Neselioglu [4]. Using this technique, disulphide bonds were degraded to free thiol groups via NaBH4.…”

Hubungan Indeks Massa Tubuh dan Kelembaban Kulit dengan Kejadian Pityriasis Versicolor pada Petugas Sampah di Purwodadi

“…Pityriasis versicolor (Pv) juga dikenal sebagai tinea versikolor adalah infeksi jamur superfisial pada kulit yang disebabkan oleh spesies Malassezia spp yang pada keadaan normal merupakan organisme komensal kulit manusia. 1 Pv ditandai oleh makula tidak teratur, plak berbatas tegas, tipis, berupa makula hipopigmentasi, hiperpigmentasi, atau eritematosa pada kulit. 2 Prevalensi Pv di negara tropis, seperti di Indonesia yaitu 50% sampai 60%, sedangkan di negara beriklim dingin seperti Swedia yaitu 0,5% sampai 1,1 %.…”