Investigation of the relationship between seborrheic dermatitis and metabolic syndrome parameters

Abstract

Seborrheic dermatitis (SD) is a chronic superficial disease that is more common in 3%-5% of the population (2.35%-11.3%) especially in men. It is frequently involved in skin folds such as the scalp, eyebrows, eyelids, nasolabial region, ear, sternal region, axilla, under the breasts, navel, and inguinal region. It is common in the infantile and adolescence period, increases after the age of 50. 1,2 The most accused in its etiopathogenesis can be listed as seborrhea, microbial factors such as malassezia, candida, immunological disorders such as demodex parasite, androgenic hormones, HIV carrier, drugs, nutritional disorders, hereditary factors, atopy, physical factors such as UV and sun, lifestyle, stress. Various neurological diseases such as Parkinson's can be seen together with SD. [3][4][5] Skin diseases such as psoriasis, atopic dermatitis, acne, and rosacea are also frequently associated with SD. 3 Its etiopathogenesis is not fully elucidated, and it is thought to be an abnormal local inflammatory immune response due to malessezia species and their potential metabolites. 1,2

Association between metabolic syndrome and prevalent skin diseases: A systematic review and meta‐analysis of case‐control studies

“…Previous evidence showed a lower level of HDL in people with SED compared to those without this condition 55 . Further, a recent cross‐sectional study illustrated that the prevalence of MetS was substantially higher in patients with SED than in the control group ( p = 0.004) 56 . Furthermore, the number of people with elevated TG levels in the SED group was significantly greater than in the control group ( p = 0.015).…”

Lipid Alterations and Metabolism Disturbances in Selected Inflammatory Skin Diseases

“…Considering blood lipids, Akbas et al reported that patients with SD tend to have significantly higher total cholesterol concentration and LDL along with lower HDL [ 60 ]. The same authors suggested that the presence of MS, particularly dyslipidemia, may increase the risk of SD appearance and its severity [ 60 ].…”

“…Considering blood lipids, Akbas et al reported that patients with SD tend to have significantly higher total cholesterol concentration and LDL along with lower HDL [ 60 ]. The same authors suggested that the presence of MS, particularly dyslipidemia, may increase the risk of SD appearance and its severity [ 60 ]. They suggested that involvement of particular sites with SD lesions may be more predictive of MS, especially the scalp, eyebrows, and nasolabial folds [ 60 ].…”

“…The same authors suggested that the presence of MS, particularly dyslipidemia, may increase the risk of SD appearance and its severity [ 60 ]. They suggested that involvement of particular sites with SD lesions may be more predictive of MS, especially the scalp, eyebrows, and nasolabial folds [ 60 ]. Imamoglu et al did not observe any significant differences between patients and controls except for lower HDL [ 61 ].…”

Somatotypological parameters of the body in men and women with seborrheic dermatitis of varying severity

“…Overweight, short stature is one of the main risk factors for the development of this disease in different ethno-territorial groups. The pathogenetic link between abdominal obesity and SD is quite clear: the severity of skin manifestations in overweight patients is registered much more often than in normal weight patients [3]. Previous studies have examined individual predictors of clinical prognosis in patients with SD, and there are virtually no studies that would conduct a comprehensive analysis of clinical and anthropometric predictors, which would objectify the long-term prognosis for this category of patients.…”