Dynamic thiol/disulphide homeostasis in patients with basal cell carcinoma

Demirseren, Düriye Deniz; Çiçek, Çağla; Alışık, Murat; Demirseren, Mustafa Erol; Aktaş, Akın; Erel, Özcan

doi:10.1080/15569527.2016.1268150

Cited by 39 publications

(50 citation statements)

References 6 publications

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“…Demirseren et al evaluated dynamic TDH in patients with basal cell carcinoma, and found a significant reduction in disulfide levels and increased native thiol levels. In light of these findings, the authors concluded that TDH may be dysregulated in the proliferative phase of the disease [24]. In this study, native thiol levels did not differ significantly between patients with AV and the control subjects, while total thiol levels were found to be significantly lower in patients with AV.…”

Section: Discussioncontrasting

confidence: 40%

Evaluation of thiol/disulfide homeostasis in patients with acne vulgaris

Gürel¹

2019

Ann Clin Anal Med

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Aim: Acne vulgaris (AV) is a chronic, multifactorial, inflammatory disease of the pilosebaceous unit. In this study, we compare the dynamic thiol/disulfide homeostasis (TDH) of patients with AV with that of control subjects. Material and Method: In this study, the dynamic TDH in patients with AV was measured and compared with that of the control subjects using the method following Erel and Neselioglu. Results: The patient group comprised 38 female and 36 male patients, and the control group comprised 29 female and 31 male subjects. The total thiol levels were significantly lower in patients with AV than in the control subjects (p=0.044), and the disulfide/total thiol ratio was significantly lower in patients with AV (p=0.034). Plasma native thiol, total thiol, and disulfide levels did not differ significantly between the subgroups (p>0.05), and the disulfide/native thiol ratio, disulfide/total thiol ratio, and native thiol/total thiol ratio did not differ significantly among the patients with mild, moderate, and severe disease (p>0.05). Discussion: To our knowledge, this is the first study to evaluate TDH in patients with AV. Plasma thiol levels, an important component of the antioxidant system, are found to be significantly lower in AV.

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Section: Discussioncontrasting

confidence: 40%

Evaluation of thiol/disulfide homeostasis in patients with acne vulgaris

Gürel¹

2019

Ann Clin Anal Med

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“…Thiol disulfide homeostasis in patients with basal cell carcinoma, psoriasis and seborrheic dermatitis has changed as the increased NT. It has been suggested that increased NT levels cause proliferation, whereas reduced NT along with the increased disulfide results in cell apoptosis [70][71][72].…”

Section: Dermatologic Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…The thiol-disulphide balance has been researched in a limited number of dermatoses (urticaria, basal cell carcinoma, atopic dermatitis) until now [9,10,18]. Demirsen et al carried out research on 34 patients with basal cell carcinoma and a group of 30 healthy individuals to determine the thiol-disulphide balance.…”

Section: Discussionmentioning

confidence: 99%

“…They observed a statistically significant difference between the disulphide/native thiol and native thiol/total thiol ratios and the serum native thiol and disulphide levels between the patient and healthy groups. This established that the thiol-disulphide balance could be a factor in the pathogenesis of basal cell carcinoma [10]. In another study undertaken by Akbas et al, the thiol/disulphide homeostasis was examined in 53 patients with acute urticaria and 47 healthy individuals, and 57 patients with chronic spontaneous urticaria and 57 healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that the plasma total thiol level measurement and the determination of thiol-disulphide balance is a good reflection of excess free radical formation in many diseases [8]. Research on the thiol-disulphide balance has determined that it plays a significant role in the pathogenesis of a few skin diseases such as urticaria [9] and basal cell carcinoma [10]. Psoriasis is one of the diseases in which oxidative stress is a factor in its etiopathogenesis [11].…”

Section: Introductionmentioning

confidence: 99%

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Thiol/disulphide balance in patients with psoriasis

Aksoy

Kirmit

2020

pdia

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A b s t r a c tIntroduction: Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis. Aim: To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group. Material and methods: Eighty patients with psoriasis and 80 healthy individuals who were age-and gender-matched with these patients were included in this study. Serum native thiol, disulfide and total thiol levels were measured by a new automated method developed by Erel and Neselioglu. Disulphide/total thiol, disulphide/ native thiol and native thiol/total thiol were calculated. Results: While there was no statistically significant difference in terms of disulphide levels (SS) between the patient and control groups (p > 0.05), there were significant differences in terms of total thiol and native thiol (SH) levels, SS/SH, SS/total thiol and SH/total thiol ratios between the patient and control groups (p < 0.05). There was a statistically significant relationship between duration of the disease and the disulfide/native thiol ratio (p > 0.05). Conclusions: In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative stress in the pathogenesis of psoriasis.

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Dynamic thiol/disulphide homeostasis in patients with basal cell carcinoma

Abstract: Thiol disulphide homeostasis in patients with basal cell carcinoma alters in the way that disulphide gets lower and thiols get higher. Thiol/disulphide level is likely to have a role in basal cell carcinoma pathogenesis.

Cited by 39 publications

References 6 publications

Evaluation of thiol/disulfide homeostasis in patients with acne vulgaris

Evaluation of thiol/disulfide homeostasis in patients with acne vulgaris

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol/disulphide balance in patients with psoriasis

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