The relatively high proportion of EV patients without mutation in TMC6/8 indicates the existence of EV-causing mutations in additional, presently unknown gene(s). However, a homozygous TMC8 splice site mutation in our patients resulted in aberrant transcripts which cannot retain the healthy phenotype. The literature review revealed that HPV-5 is the most commonly identified HPV in patients with EV, but HPV-3, HPV-14 and HPV-20 were unexpectedly identified more frequently than HPV-8.

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Acne prevalence is high among adolescents in Eskisehir but the rate of consulting doctor is low. Increasing public awareness is critical for convincing adolescents to seek medical help earlier. Acne was related with dietary habits. Fat, sugar and fast food consumption is found to be positively correlated with acne prevalence.

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Psoriasis is a chronic autoimmune disease in which peripheral blood mononuclear cells (PBMCs) are involved in the pathological process. Transient receptor potential (TRP) channels expressed in immune cells have been shown to be associated with inflammatory diseases. We aimed to evaluate mRNA expression levels of TRP channels in PBMCs of patients with psoriasis. 30 patients with plaque psoriasis and 30 healthy age- and gender-matched control subjects were included in this study. mRNA expression levels of TRP channels in psoriasis patients were determined by Real-time polymerase chain reaction. A decreased TRPM4, TRPM7, TRPV3, TRPV4, and TRPC6 genes expression levels were found in the patient group compared to controls, respectively ( p = 0.045, p = 0.000, p = 0.000, p = 0.045, p = 0.009), whereas, an increased expression level was found in TRPM2 and TRPV1 genes in the patient group compared to controls ( p = 0.001 and p = 0.028). This is the first study showing the TRP channel mRNA expressions in PBMCs of psoriasis patients. Different expression patterns of TRP channels may have a role in pathogenesis of psoriasis.

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soriasis is a chronic inflammatory skin disease with a prevalence rate of 2-3 percent in the population. 1 Psoriasis has a complex and multifactorial etiology and pathogenesis of disease is still unclear. 2 Previously, psoriasis was described as a disease associated with epidermal hyperproliferation, shortening of epidermal turnover time, and impaired

Background and Design: Acne vulgaris (AV) is one of the most common dermatological diseases seen in late childhood and adolescence. The purpose of this study is to evaluate ischemia-modified albumin (IMA) levels in AV, a cutaneous inflammatory disease. Materials and Methods: Seventy-four patients between 15 and 30 years of age with clinically diagnosed AV, and 60 healthy age and sex matched controls without AV were enrolled in the study. Serum IMA levels were measured using the albumin cobalt binding test. The capacity of cobalt binding to albumin decreases under ischemic conditions. Patient serum is mixed with cobalt chloride and incubated for 5 minutes, during which the cobalt is allowed to bind to the albumin. This is mixed with dithiothreitol (DTT) following incubation, and result in a colored complex with cobalt unbound to albumin for DTT. The resulting colored complex is measured spectrophotometrically at a wavelength of 500 nm. Results: The mean age of the AV group with AV was 18.54 (±3.40), and the mean age of the control group was 17.68 (±3.37). The mean IMA level in the AV patients was 0.82±0.023, compared to 0.80±0.017 in the control group. The difference between the two groups was statistically significant (p<0.001). No significant difference was determined among the AV subgroups in terms of IMA levels. Conclusion: Our search of the PubMed database revealed no previous studies investigating IMA levels in patients with AV. Akne vulgaris hastalarında iskemi-modifiye albümin düzeyinin değerlendirilmesiEvaluation of ischemia-modified albumin levels in acne vulgaris patients Amaç: Akne vulgaris (AV), geç çocukluk ve ergenlik çağında sık görülen yaygın dermatolojik hastalıklardan biridir. Bu çalışmada, kutanöz enflamatuvar bir hastalık olan AV'de, iskemi-modifiye albümin (İMA) seviyelerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya klinik olarak AV tanısı konulan 15-30 yaş arasında 74 hasta ile yaş ve cinsiyet açısından eşleştirilmiş AV hastalığı olmayan 60 sağlıklı kontrol alındı. Serum İMA düzeyi, albümin kobalt bağlama testi ile ölçüldü. İskemik durumlarda, kobaltın albümine bağlanmasının azaldığı bilinmektedir. Hasta serumu, kobalt klorid ile karıştırılıp 5 dakika süreyle inkübe edilir. Bu süreçte kobaltın albümine bağlanması sağlanır. İnkübasyondan sonra ditiyotreitol (DTT) eklenerek karıştırılır ve DTT'nin albümine bağlanmamış kobalt ile renkli bir kompleks oluşturması sağlanır. Oluşan renkli kompleks 500 nm dalga boyunda spektrofotometrik olarak ölçülür. Bulgular: AV'li hasta grubunun yaş ortalaması 18,54 (±3,40), kontrol grubunun yaş ortalaması ise 17,68 (±3,37) olarak saptandı. AV hastalarında ortalama İMA düzeyi 0,82±0,023 iken, kontrol grubunda ortalama İMA düzeyi 0,80±0,017 olarak saptandı. İki grup arasında İMA düzeyi açısından istatistiksel olarak anlamlı fark saptandı (p<0,001). AV hastalarının alt grupları arasında İMA düzeyleri açısından anlamlı farklılık tespit edilmedi. Sonuç: PubMed veri tabanı araştırıldığında AV hastalarında İMA düzeylerini araştıran başka çalışmaya r...