Dynamic thiol/disulfide homeostasis in patients with lichen planus

Kalkan, Göknur; Emre, Selma; Alışık, Murat; Aktaş, Akın; Baran, Pervin

doi:10.1002/jcla.22642

Cited by 14 publications

(19 citation statements)

References 19 publications

(47 reference statements)

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“…Kalkan et al, were first to analyze TDH in LP patients and determined significantly higher serum levels of NT and TT in LP patients compared to controls. The serum DS levels did not vary significantly between the two groups [33]. In our study, we found a higher level of DS in LP patients compared to controls.…”

Section: Discussionsupporting

confidence: 42%

“…The determination of the global antioxidant status using the serum TAS level allows for the evaluation of all components in a sample; it is a method that is less expensive and faster than the individual determination of each parameter [4,41]. The level of thiols represents a reliable marker for evaluating the global antioxidant status, given that thiols represent 52.9% of total serum antioxidant capacity [33].…”

Section: Resultsmentioning

confidence: 99%

“…Under conditions of chronic inflammation and oxidative stress, cells develop their own mechanisms of protection. These mechanisms include redox systems such as -SH / -SS- (thiol/disulfide system), NADH/NAD + , NADPH/NADP + , and Trx(SH)2 / Trx(SS) (thioredoxin system) [31,32,33]. Recent studies have shown that the thiol-disulfide system can be regarded as an adaptive response of cells under conditions of chronic inflammation and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis

et al. 2019

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The constant generation of reactive carbonyl species (RCSs) by lipid peroxidation during aerobic metabolism denotes their involvement in cell homeostasis. Skin represents the largest organ of the body that is exposed to lipid peroxidation. Previous studies have suggested the involvement of oxidative stress in the development of lichen planus (LP), a chronic inflammatory skin condition with a complex pathogenesis. The aim of our study is to investigate a panel of pro-oxidants (4-hydroxy-nonenal (4-HNE), thiobarbituric acid reactive substances (TBARS), and malondialdehyde (MDA)), the total antioxidant status (TAS), and thiol-disulfide homeostasis parameters (TDHP), including total thiol (TT), native thiol (NT), disulfides (DS), DS/NT ratio, DS/TT ratio, and NT/TT ratio. The comparative determinations of serum levels of 4-HNE, TBARS, and MDA in patients with LP (n = 31) and controls (n = 26) show significant differences between the two groups (4-HNE: 7.81 ± 1.96 µg/mL vs. 6.15 ± 1.17 µg/mL, p < 0.05, TBARS: 4.23 ± 0.59 µmol/L vs. 1.99 ± 0.23 µmol/L, p < 0.05, MDA: 32.3 ± 6.26 ng/mL vs. 21.26 ± 2.36 ng/mL). The serum levels of TAS are lower in LP patients compared to the control group (269.83 ± 42.63 µmol/L vs. 316.46 ± 28.76 µmol/L, p < 0.05). The serum levels of TDHP are altered in LP patients compared to controls (NT: 388.10 ± 11.32 µmol/L vs. 406.85 ± 9.32., TT: 430.23 ± 9.93 µmol/L vs. 445.88 ± 9.01 µmol/L, DS: 21.06 ± 1.76 µmol/L vs. 19.52 ± 0.77µmol/L). Furthermore, a negative association between pro-oxidants and TAS is identified (4-HNE – rho = −0.83, p < 0.01, TBARS – rho = −0.63, p < 0.01, and MDA – rho = −0.69, p < 0.01). Understanding the mechanisms by which bioactive aldehydes exert their biological effects on the skin could help define effective therapeutical strategies to counteract the cytotoxic effects of these reactive metabolic intermediates.

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Section: Discussionsupporting

confidence: 42%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis

et al. 2019

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“…Kalkan et al 24 examined the thiol/disulphide balance in patients with lichen planus, and reported a significant increase in thiol levels in the patient group which supported the thesis of Erel and Neselioğlu stating an increase in thiol levels and a decrease in disulphide levels in proliferative diseases. Thiol/disulphide homeostasis has been examined in many diseases other than dermatological diseases, and while an increase has been determined in thiol levels in proliferative diseases such as multiple myeloma, disulphide levels have been reported to be significantly increased in degenerative diseases such as acute pancreatitis 25,26 …”

Section: Discussionmentioning

confidence: 53%

The evaluation of thiol/disulphide homeostasis in recurrent aphthous stomatitis

Yavuz

Kurku

Neşeli̇oğlu

2020

Dermatologic Therapy

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The objective of our study was to determine thiol/disulphide homeostasis in recurrent aphtous stomatitis (RAS) patients. A prospective monocentric study was designed. Forty-three recurrent aphtous stomatitis patients and 43 healthy subjects were included to study. Venous blood samples collected and assessed with novel automatic system. Results compared statistically. Disulphide levels were found significantly higher in RAS patients than control group. There was no significant difference between native thiol and total thiol levels. Thiol/disulphide homeostasis is impaired in RAS patients in favor of disulphide levels compared with control group. To the best of our knowledge, the present study is the first examination on the correlation between thiol and disulfide homeostasis in patients with RAS. K E Y W O R D S recurrent aphtous stomatitis, thiol/disulphide homeostasis 1 | INTRODUCTION Recurrent aphthous stomatitis (RAS) is the most frequently seen painful intra-oral lesion. It generally starts in childhood or adolescence and recurs in the form of many small ulcers, which have round or ovoid borders on a yellow or gray base with erythematous surroundings. 1 The frequency and severity shows a decrease after the age of 50 years. In 1972, RAS were classified by Stanley in three groups as minor, major, and herpetiform. 2 Predisposing factors include genetic predisposition, oral trauma, hematological deficiencies such as iron, B12 and folic acid deficiencies, the use of ACE inhibitors, captopril and NSAIDs, inflammatory bowel diseases, celiac disease, oral hygiene products containing sodium lauryl sulphate, hormonal changes, and microorganisms. Recurrent aphthous stomatitis diagnosis is based on the history, examination, and histopathological features. Other causes of oral ulcers must be excluded. In 2004, Natah et al 3 defined a classification for minor RAS patients according to which they are separated as idiopathic and secondary. The causes of secondary RAS include Behcet's disease, MAGIC syndrome, PFAPA syndrome, Sweet syndrome, cyclic neutropenia, and HIV infection. Many biochemical markers have been used to reveal oxidative stress and inflammation, one of which is the thiol/disulphide balance. Dynamic thiol/disulphide homeostasis has an active role in many vital events such as programmed cell death, detoxification, antioxidant defense, cellular enzymatic activity, transcription, and cellular signal transmission mechanisms. When disulphide increases in the thiol/disulphide balance vital activities are affected and pathologies emerge leading to impairments in the function and structure of many organs. 4,5 Thiol groups form disulphide bonds under oxidative stress, and the conversion of thiols to disulphide bonds is seen as an early finding of increased oxidative stress. When the stress is removed the disulphide bonds revert to thiol groups. This formation and conversion process is known as thiol/disulphide homeostasis. 6 To the best of our knowledge, there has been no previous study which has evaluated thiol/disulp...

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“…The diagnostic criteria for AIG are: the presence of antiparietal cell antibodies, elevated blood gastrin levels and the presence of histology suggesting chronic AIG, including intestinal metaplasia, pseudopyloric metaplasia, or atrophy of the gastric fundus or body [1]. Subjects with concomitant disorders that may influence TDH [2,[20][21][22][23], atherosclerotic disorders, diabetes mellitus, kidney disorders, thyroid and liver diseases, malignancy, rheumatic disorders, systemic or other dermatologic diseases, acute or chronic pancreatitis, psychiatric disorders, autoimmune disorders, patients using antioxidant or antilipid agents, and tobacco and alcohol users were excluded from the study. The control group was selected from subjects who were admitted for screening and check-up purposes.…”

Section: Patientsmentioning

confidence: 99%

Thiol/disulphide homeostasis and ischemia modified albumin levels in autoimmune gastritis and their relations with gastric emptying

Erel

et al. 2020

Turk J Med Sci

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Background/aim: Autoimmune gastritis is an autoimmune and inflammatory disorder. The aim of this study is to examine dynamic thiol/disulfide homeostasis and ischemia modified albumin levels, and to analyze the association between thiol/disulfide homeostasis and gastric emptying time in autoimmune gastritis. Materials and methods:Thiol/disulfide homeostasis tests and ischemia modified albumin levels were determined in 50 autoimmune gastritis patients and 53 healthy subjects. Patients with delayed and normal gastric emptying were compared by thiol/disulfide homeostasis tests. Results:The results showed that native thiol (μmol/L), total thiol (μmol/L), and native thiol/total thiol ratio (%) of the patients with autoimmune gastritis decreased compared to the control group (177.7 ± 34.18 vs. 245.25 ± 33.83, P = 0.001, 227.25 ± 36.78 vs. 284.20 ± 27.19, P = 0.03, and 8.84 ± 1.1 vs. 7.74% ± 1.3%, P = 0.001). In addition, native thiol (μmol/L), total thiol (μmol/L), and native thiol/ total thiol ratio (%) were found to be lower in patients with delayed gastric emptying (198.65 ± 24.27 vs. 167.12 ± 20.51, 241.81 ± 27.14 vs. 213.92 ± 26.35, 8.34 ± 1.29 vs. 7.20 ± 1.83, P = 0.001). Disulfide level, disulfide/native thiol, disulfide/total thiol (P = 0.001) ratios, and ischemia modified albumin levels (ABSU, 0.71 ± 0.08 vs. 0.83 ± 0.07) were found to be higher in autoimmune gastritis patients with delayed gastric emptying (P = 0.001). Conclusion:The results showed that thiol/disulfide homeostasis in patients with autoimmune gastritis caused an increase in ischemia modified albumin and disulfide whereas a decrease in thiols. An altered thiol/disulfide balance was also observed in patients with delayed gastric emptying. These results suggest that the oxidative process is involved in patients with autoimmune gastritis.

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Dynamic thiol/disulfide homeostasis in patients with lichen planus

Cited by 14 publications

References 19 publications

Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis

Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis

The evaluation of thiol/disulphide homeostasis in recurrent aphthous stomatitis

Thiol/disulphide homeostasis and ischemia modified albumin levels in autoimmune gastritis and their relations with gastric emptying

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