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We fabricate an operational amplifier (op-amp) composed with the coplanar amorphous indium-gallium-zinc oxide (a-IGZO) thin-film transistors (TFTs). The circuit consisted of 19-TFTs and designed on a glass substrate in both dual gate (DG) and single gate (SG) structure for performance evaluation. Having the yield of a total voltage gain (A v ) of 23.5 dB, a cutoff frequency (f c ) of 500 kHz, a unit gain frequency (f ug ) of 2.37 MHz, gain-bandwidth product (GBWP) of 7500 kHz, a slew rate (up/down) of (2.1/1.2) V/µs, and a phase margin (PM) of 102 • at a supply voltage of ±10 V, the fabricated DG TFT op-amp demonstrates good performance among all a-IGZO-based literature. INDEX TERMSCoplanar a-IGZO TFTs, dual gate, single gate, operational amplifier (op-amp).

The COVID-19 outbreak resulted in preventative measures and restrictions for Bangladesh during the summer of 2020—these unstable and stressful times led to multiple social problems (e.g., domestic violence and divorce). Globally, researchers, policymakers, governments, and civil societies have been concerned about the increase in domestic violence against women and children during the ongoing COVID-19 pandemic. In Bangladesh, domestic violence against women and children has increased during the COVID-19 pandemic. In this article, we investigated family violence among 511 families during the COVID-19 outbreak. Participants were given questionnaires to answer, for a period of over ten days; we predicted family violence using a machine learning-based model. To predict domestic violence from our data set, we applied random forest, logistic regression, and Naive Bayes machine learning algorithms to our model. We employed an oversampling strategy named the Synthetic Minority Oversampling Technique (SMOTE) and the chi-squared statistical test to, respectively, solve the imbalance problem and discover the feature importance of our data set. The performances of the machine learning algorithms were evaluated based on accuracy, precision, recall, and F-score criteria. Finally, the receiver operating characteristic (ROC) and confusion matrices were developed and analyzed for three algorithms. On average, our model, with the random forest, logistic regression, and Naive Bayes algorithms, predicted family violence with 77%, 69%, and 62% accuracy for our data set. The findings of this study indicate that domestic violence has increased and is highly related to two features: family income level during the COVID-19 pandemic and education level of the family members.

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Parkinson’s disease (PD) is a neurodegenerative disorder responsible for shaking, rigidity, and trouble in walking and patients’ coordination ability and physical stability deteriorate day by day. Bipolar disorder (BD) is a psychiatric disorder which is the reason behind extreme shiftiness in mood, and frequent mood inversion may reach too high called mania. People with BD have a greater chance of developing PD during the follow-up period. A lot of work has been done to understand the key factors for developing these 2 diseases. But the molecular functionalities that trigger the development of PD in people with BD are not clear yet. In our study, we are intended to identify the molecular biomarkers and pathways shared between BD and PD. We have investigated the RNA-Seq gene expression data sets of PD and BD. A total of 45 common unique genes (32 up-regulated and 13 down-regulated) abnormally expressed in both PD and BD were identified by applying statistical methods on the GEO data sets. Gene ontology (GO) and BioCarta, KEGG, and Reactome pathways analysis of these 45 common dysregulated genes identified numerous altered molecular pathways such as mineral absorption, Epstein-Barr virus infection, HTLV-I infection, antigen processing, and presentation. Analysis of protein-protein interactions revealed 9 significant hub-proteins, namely RPL21, RPL34, CKS2, B2M, TNFRSF10A, DTX2, HLA-B, ATP2A3, and TAPBP. Significant transcription factors (IRF8, SPI1, RUNX1, and FOXA1) and posttranscriptional regulator microRNAs (hsa-miR-491-3p and hsa-miR-1246) are also found by analyzing gene-transcription factors and gene-miRNAs interactions, respectively. Protein-drug interaction analysis revealed hub-protein B2M’s interaction with molecular drug candidates like N-formylmethionine, 3-indolebutyric acid, and doxycycline. Finally, a link between pathological processes of PD and BD is identified at transcriptional level. This study may help us to predict the development of PD among the people suffering from BD and gives some clue to understand significant pathological mechanisms.

In Southern Asia, Bangladesh is a well-known developing country. Because of COVID-19, we continuously face challenges. Not only can these issues occur beyond economic or health concerns, but they also generate dangerous social problems, such as family abuse. Since the inception of this epidemic, multiple social crimes are looming. Remaining home during the lockout period enhances divorce rates. This research presents a customized forecast of family violence during the COVID-19 outbreak by using machine learning methods. In this paper, we have applied Random Forest, Logistic Regression, and Naive Bayes machine learning classifiers to predict family violence and discovered the feature importance. The performance of the classifiers is evaluated based on accuracy, precision, recall, and F-score. We have employed an oversampling strategy named synthetic minority oversampling technique (SMOTE) to solve the imbalance problem of our data. Even, we have tried to compare three machine learning model performances before and after balancing of normalization data. Finally, ROC analyses and confusion matrices were developed and analyzed by using data augmentation. Our proposed system with the random forest classifier performed better with 77% accuracy in comparison with other two machine learning classifiers.