2011
DOI: 10.1590/s1678-91992011000200015
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Venous ulcers of the lower limbs complicated by infection or chronicity represent a serious public health problem. The elevated number of those afflicted burdens the health services, interferes in quality of life and causes absenteeism. Although there are 2,500 items on the market, ranging from the simplest dressing up to the most complex types of dressing, treatment remains a challenge. Among the substances used, fibrin sealant is the one that promotes diminution of bacterial colonization and of edema, contro… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
22
0

Year Published

2014
2014
2021
2021

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 26 publications
(23 citation statements)
references
References 17 publications
1
22
0
Order By: Relevance
“…Thus, preclinical trials applying the product in the peripheral nervous and musculoskeletal systems [46–56] and as a scaffold for stem cells have been studied extensively [5760]. Trials in plastic surgery skin repair [61], periodontal surgery [6264] and in chronic venous ulcers have also been performed [41, 65]. In addition to treating chronic venous ulcers, further clinical trials, especially ones linked to the nervous system and to skeletal muscle, will allow for a more precise use.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, preclinical trials applying the product in the peripheral nervous and musculoskeletal systems [46–56] and as a scaffold for stem cells have been studied extensively [5760]. Trials in plastic surgery skin repair [61], periodontal surgery [6264] and in chronic venous ulcers have also been performed [41, 65]. In addition to treating chronic venous ulcers, further clinical trials, especially ones linked to the nervous system and to skeletal muscle, will allow for a more precise use.…”
Section: Discussionmentioning
confidence: 99%
“…In an attempt to overcome these difficulties, another sealant consisting of a thrombin-like enzyme extracted from snake venom and fibrinogen obtained from large animals to replace human components has shown excellent results in experimental studies on the regeneration of different tissues [14][15][16][17][18] , in mesenchymal cell cultures 19 , and in the healing of skin wound, venous ulcers and gingival graft sutures in humans 20,21 . This new sealant is a biodegradable product that does not cause adverse reactions, does not contain human blood components, has good adhesive capacity, and does not transmit infectious diseases 22 . Considering these favorable properties, this new sealant should be explored clinically in different regenerative therapies.…”
Section: Introductionmentioning
confidence: 99%
“…We included 37 studies (38 publications) enrolling a total of 3,990 patients (Figure ) . Thirty‐six of 37 studies were RCTs, one was a nonrandomized trial, and another was a retrospective cohort study.…”
Section: Resultsmentioning
confidence: 99%