Topical silver for preventing wound infection

Storm‐Versloot, Marja N.; Vos, Cornelis G.; Ubbink, Dirk T.; Vermeulen, Hester

doi:10.1002/14651858.cd006478.pub2

Cited by 192 publications

(182 citation statements)

References 71 publications

Supporting

Mentioning

169

Contrasting

Unclassified

Order By: Relevance

“…The silver dressing did not increase the overall healing rate, but it was associated with quicker healing in larger and older ulcers. An extensive metastudy by Storm-Versloot et al 79 confirmed these findings in that most studies on silver dressings for nonhealing wounds did not show a significant reduction of infection when silver sulfadiazine cream or silver dressings were used. Wound healing was found to vary among the different studies reviewed, depending on the type of wounds included in the study and the exact dressing used.…”

Section: Wound Dressings Impregnated With Silver Nanoparticlesmentioning

confidence: 84%

“…Wound healing was found to vary among the different studies reviewed, depending on the type of wounds included in the study and the exact dressing used. 79 A chitosan-nanocrystalline silver dressing showed superior healing rates (89%) compared with silver sulfadiazine dressings (68%) and chitosan film (74%). 80 In addition, the chitosan-nanocrystalline silver dressing deposited far less silver than did conventional silver sulfadiazine, 80 thus demonstrating that the use of silver nanoparticles may be safer in reducing the incidence of argyria and argyremia (elevated silver concentration in the blood).…”

Section: Wound Dressings Impregnated With Silver Nanoparticlesmentioning

confidence: 97%

See 1 more Smart Citation

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Gunasekaran¹,

Nigusse

Dhanaraju³

2011

Journal of the American College of Clinical Wound Specialists

175

110

View full text Add to dashboard Cite

Nanotechnology is on the threshold of providing a host of new materials and approaches, revolutionizing the medical and pharmaceutical fields. Several areas of medical care are already profiting from the advantage that nanotechnology offers. Recently, silver nanoparticles are attracting interest for a clinical application because of its potential biological properties such as antibacterial activity, anti-inflammatory effects, and wound healing efficacy, which could be exploited in developing better dressings for wounds and ulcers. This article reviews the role of silver nanoparticles in wound healing.

show abstract

Section: Wound Dressings Impregnated With Silver Nanoparticlesmentioning

confidence: 84%

Section: Wound Dressings Impregnated With Silver Nanoparticlesmentioning

confidence: 97%

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Gunasekaran¹,

Nigusse

Dhanaraju³

2011

Journal of the American College of Clinical Wound Specialists

175

110

View full text Add to dashboard Cite

show abstract

“…For instance, ionic-silver-containing alginate dressings demonstrated broad-spectrum in vitro activity against Candida albicans, E. coli, P. aeruginosa, S. aureus, b-haemolytic Streptococcus and strictly anaerobic bacteria (Hooper et al, 2012), and good clinical outcomes were described for carboxymethyl cellulose dressings with ionic silver (Beele et al, 2010). In contrast, a systematic review of the Cochrane Collaboration comparing silver-containing dressings against non-medicated dressings concluded that 'there is insufficient evidence to establish whether silver-containing dressings or topical agents promote wound healing or prevent wound infection' (Storm-Versloot et al, 2010). Polyurethane foam or biocellulose wound dressings containing 0.5 % PHMB were even more effective in reducing pain and bacterial burden in infected acute and chronic wounds compared with silver dressings (Eberlein & Assadian, 2010;Eberlein et al, 2012).…”

Section: Potential Use Of Cpc and Mstmentioning

confidence: 99%

Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations

Fromm‐Dornieden

Rembe

Schäfer

et al. 2015

Journal of Medical Microbiology

View full text Add to dashboard Cite

The antimicrobial activity of cetylpyridinium chloride (CPC) and miramistin (MST) solutions at different concentrations (5¾10 "5 to 0.4 %) and a dressing, containing 0.15 % CPC, were tested against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli after 30 (solutions) and 60 min (fleece) incubation, respectively. Furthermore, the cytotoxic effects of CPC and MST were examined in human keratinocyte (HaCaT) and murine fibroblast (L929) cell lines. A dose of 3¾10 "3 % CPC or MST was sufficient to entirely eradicate S. aureus after 30 min incubation. To achieve the same effect, higher concentrations were required against E. coli (0.025 % CPC; 0.0125 % MST) and P. aeruginosa (0.5 % CPC; 0.05 % MST). The CPC-fleece showed a high antiseptic effect against all three bacterial strains, although it did not completely eliminate P. aeruginosa. Both substances showed a high cytotoxic impact at higher tested concentrations (CPC .3¾10 "3 %; MST .8¾10 "4 %). CPC showed high antimicrobial potency at low concentrations against S. aureus, accompanied by low cytotoxic (side) effects at these concentrations, whilst the required minimal concentration to eradicate E. coli and P. aeruginosa was shown to be cytotoxic for keratinocytes and fibroblasts. The necessary antibacterial amounts of MST were lower, but also cytotoxic in direct contact with typical human wound cells. With regard to demographic changes and increasing bacterial resistance, new effective antiseptics, such as CPC and MST, incorporated in wound dressings without releasing an active substance could help to improve the treatment and healing rates of chronic wounds.

show abstract

“…In 2010, a Cochrane Review did not identify an association between the use of topical silver dressings and either promotion of wound healing or wound infection prophylaxis. 27 Within a decade of the widespread use of topical silver wound treatments, leukopenia was observed in patients with burn wounds treated with silver agents. 28 In addition to medical exposure, there are several acute and chronic routes of exposure to silver, including ingestion, inhalation, and dermal absorption.…”

Section: Discussionmentioning

confidence: 99%

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

LaRiviere

Goldin

Avansino

2011

The Journal of the American College of Certified Wound Speciali

View full text Add to dashboard Cite

Silver-containing topical agents are used to help prevent infectious complications in wound therapy. Toxicity from topical silver agent exposure was initially reported in 1975 and was clinically characterized by granulocytopenia. Currently, the data regarding potential toxicity associated with silver-impregnated devices are limited. A 23-year-old patient receiving chemotherapy for acute lymphoblastic leukemia presented with necrotizing fasciitis of the abdominal wall and scrotum from a Crohn disease-related psoas-enteric fistula. Surgical debridement of the soft-tissue and abdominal musculature was performed to the peritoneum. Silver-containing foam sponges and wound vacuumassisted closure were applied directly to the peritoneum 2 weeks after initial debridement. Subsequently, the patient developed leukopenia, and workup revealed the serum silver level was 4 times normal level. Silver-impregnated sponges were discontinued and silver-free sponges and wound vacuum-assisted closure therapy resumed, followed by leukopenia resolution. Silver toxicity associated with routine application of silver-impregnated sponges has not been previously reported.

show abstract

Topical silver for preventing wound infection

Abstract: There is insufficient evidence to establish whether silver-containing dressings or topical agents promote wound healing or prevent wound infection; some poor quality evidence for SSD suggests the opposite.

Cited by 192 publications

References 71 publications

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Silver Nanoparticles as Real Topical Bullets for Wound Healing

Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations

Silver Toxicity With the Use of Silver-Impregnated Dressing and Wound Vacuum-Assisted Closure in an Immunocompromised Patient

Contact Info

Product

Resources

About