Sumithion Induced Hepatic Injury in the Toads Bufo tibamicus

Sakr, Saber A.; ., A.M. Hijji

doi:10.3923/pjbs.2000.1705.1707

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Cytoplasmic vacuolation and degeneration of hepatocytes have been noticed in cypermethrin http://www.ijt.ir; Volume 12, No 4, July-August 2018 challenged rats. This derives support from the studies of other workers reported similar findings from toxicants treated mammals [4,[11][12][13][14][15][16][17][18][19], birds [20], amphibia [21] and fish [ 22,23]. Few investigators have not observed changes in liver after exposure to chlorpyrifos [24] and FYROL [25].…”

Section: Discussionsupporting

confidence: 74%

Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts

Srivastava

Srivastava²,

Srivastav

et al. 2018

IJT

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Background: We evaluated ameliorative effects of Jamun seed and orange peel extracts on liver toxicity in cypermethrin exposed rat. Methods: Rats were given following treatments daily for 30 d: Group A: Control Group B: Rats received cypermethrin Group C: These rats received cypermethrin and Jamun seed extract simultaneously Group D: These rats received cypermethrin and orange peel extract simultaneously Group E: Rats received orange peel extract Group F: Rats received Jamun seed extract In respective groups dose of cypermethrin, Jamun seed and orange peel extract were 25 mg/ kg body wt, 200 mg/kg body wt and 200 mg/kg body wt, respectively. Liver was fixed for light and electron microscopic studies. Results: After 15 d cypermethrin or cypermethrin+JSE or cypermethrin+OPE treatment hepatocytes exhibited increased cell size, nuclei became more hyperchromatic and hypertrophied. Degeneration of nuclei and dilatation of sinusoids have been noticed. After 30 d cypermethrin treatment hepatocytes exhibit more pronounced hypertrophy with hyperchromatic nuclei. Few hepatocytes exhibit nuclei with irregular boundaries. Hepatocytes show foamy cytoplasm and few vacuoles. Focal necrosis visible at certain places. Binucleated cells are also encountered. In cypermethrin+JSE and cypermethrin+OPE treated rats, hepatocytes exhibit hypertrophy, hyperchromatic nuclei and dilatation of sinusoids. Degeneration of hepatocytes are seen at some places, however, focal necrosis is not seen in these groups. No noticeable histological alterations are seen in orange peel extract (group E) and jamun seed extract (group F) treated rats. Conclusion: Cypermethrin induced hepatic toxicity can be protected by treatment with Jamun seed and orange peel extract.

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