Histopathological Alterations in the Liver and Kidney of Toads (Bufo regularis) Intoxicated
with a Pyrethroid Insecticide

Sakr, Saber A.; Hanafy, Safaa M

doi:10.3923/jbs.2002.208.211

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Hepatocellular damage may be related to changes of liver enzyme levels in plasma, which are indicative of liver tissue releasing enzymes when damaged or injured. Indeed, increased values of liver enzymes in plasma are commonly taken as indicators of liver damage [26]. For this reason, liver function tests can be used as markers of cell damage.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Refined Extracts of Matricaria recutita L and Chrysanthemum coronarium L, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats

Mandiola-Quililongo¹,

Soto²,

Gática³

et al. 2020

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Chamomile (Matricaria recutita L) and Chrysanthemum (Chrysanthemum coronarium L. (Garland)) are plants belonging to the family Asteraceae. The pharmacological properties of these herbs result from interactions among their many components. Of these, over 120 secondary metabolites with pharmacological and/or potential pesticide activity have been identified. The diverse chemical and biological characteristics of this set of compounds, i.e., essential oils and organic extracts of genera Matricaria and Chrysanthemum, have been shown to have particular pesticidal effects, especially those rich in pyrethroids. This work characterizes chamomile and chrysanthemum extracts for their pesticidal properties and their effects following acute exposure in rats. Results show hepatotoxic and oxidative stress-inducing effects in the livers of rats exposed to C. coronarium extracts, but not those of M. recutita.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Refined Extracts of Matricaria recutita L and Chrysanthemum coronarium L, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats

Mandiola-Quililongo¹,

Soto²,

Gática³

et al. 2020

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Inhalation Exposure of Formulated Fenvalerate (20% EC): Toxicologic Alterations in Kidney of Rats

Mani

Lal

Singh

et al. 2007

Bull Environ Contam Toxicol

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The protective effects of ginseng plant extract (ginsana) and garlic powder against the bad effects of lambda-cyhalothrin insecticide on kidneys of female rats

Mohi-Eldin

Mostafa

Kader

2012

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Ginseng and garlic are well known plants which have anti oxidant effects. The present study investigates the protective effects of ginseng extract and garlic powder on the bad effects of lambda-cyhalothrin insecticides (LTC). Eighty female Wister rats divided into 4 groups as follow; group (1) control group, group (2) injected with(9.3 mg/kg b.wt) LTC alone, group (3) injected with(200 mg/kg b.wt) ginseng extract (G115) followed by (9.3 mg/kg b.wt) LTC, group (4) injected with (100 mg/kg b.wt) garlic extract (GA) followed by (9.3 mg/kg b.wt) LTC All groups were injected intraperitonialy for 15 days (as a short term) and 21 days (as along term). Histological examination of the kidney sections showed severe congestion, besides cloudy swelling in the proximal and distal convoluted tubules, vacuolar degeneration with necrosis. In addition to edema in the bowman's space, hypercellularity and destruction with renal casts detected in some of renal tubules in animal injected with LTC only for 15 days. While rats injected with LTC for 21 days revealed thickening and edematous in the wall of the blood vessels with proliferation in the endothelial cells, besides thrombosis and hemorrhage. Chronic interstitial nephritis in most rats and perivasculitis were detected. Kidneys of rats pretreated with ginseng followed by LTC for 15 days showed protective effect in the form of disappear of the edema of bowman's space and cloudy swelling except some necrosis and slight congestion. Whereas 21 days showed high protective effects by reducing of cloudy swelling and necrosis. Garlic also diminished the pathological alterations in the kidneys but lower than ginseng. Histochemical observation revealed, increases in the protein inclusion in rats injected with (9.3 mg/kg b.wt) lambda-cyhalothrin alone in comparison with control, while ginseng and garlic groups almost have normal protein inclusion distributions to some extant.

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Histopathological Alterations in the Liver and Kidney of Toads (Bufo regularis) Intoxicated with a Pyrethroid Insecticide

Cited by 4 publications

References 10 publications

Evaluation of the Effect of Refined Extracts of <i>Matricaria recutita L</i> and <i>Chrysanthemum coronarium L</i>, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats

Evaluation of the Effect of Refined Extracts of <i>Matricaria recutita L</i> and <i>Chrysanthemum coronarium L</i>, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats

Inhalation Exposure of Formulated Fenvalerate (20% EC): Toxicologic Alterations in Kidney of Rats

The protective effects of ginseng plant extract (ginsana) and garlic powder against the bad effects of lambda-cyhalothrin insecticide on kidneys of female rats

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Histopathological Alterations in the Liver and Kidney of Toads (Bufo regularis) Intoxicated with a Pyrethroid Insecticide

Cited by 4 publications

References 10 publications

Evaluation of the Effect of Refined Extracts of &lt;i&gt;Matricaria recutita L&lt;/i&gt; and &lt;i&gt;Chrysanthemum coronarium L&lt;/i&gt;, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats

Evaluation of the Effect of Refined Extracts of &lt;i&gt;Matricaria recutita L&lt;/i&gt; and &lt;i&gt;Chrysanthemum coronarium L&lt;/i&gt;, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats

Inhalation Exposure of Formulated Fenvalerate (20% EC): Toxicologic Alterations in Kidney of Rats

The protective effects of ginseng plant extract (ginsana) and garlic powder against the bad effects of lambda-cyhalothrin insecticide on kidneys of female rats

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Product

Resources

About

Evaluation of the Effect of Refined Extracts of <i>Matricaria recutita L</i> and <i>Chrysanthemum coronarium L</i>, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats

Evaluation of the Effect of Refined Extracts of <i>Matricaria recutita L</i> and <i>Chrysanthemum coronarium L</i>, Proposed as Bio-Pesticides for Agricultural Use, Determining the Variation of Biomarkers of Oxidative and Hepatotoxic Stress in Acutely Exposed Rats