Liver profile of rats after long-term ingestion of different doses of chlorpyrifos

Tripathi, Sunil Kumar; Srivastav, Ajai K.

doi:10.1016/j.pestbp.2009.12.005

Cited by 36 publications

(24 citation statements)

References 31 publications

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“…The restoration of AST, ALT, ALP and GGT activities in the group pre-treated with vitamin C demonstrated the protective effect of the antioxidant vitamin on hepatocellular injury provoked by CPF. The restoration of hepatic enzyme activities may have been due to reduction of CPF-provoked oxidative and cytotoxic changes in the hepatocytes because of the antioxidant and free radical scavenging properties of vitamin C. The widespread hepatocellular degeneration and dilated sinusoids recorded in the CPF group, which may have been associated with oxidative injury and direct cytotoxicity evoked by the insecticide agrees with that recorded by previous studies (Tripathi and Srivastav 2010;Al-Shap et al, 2015;Tanvir et al, 2015;Ezzi et al, 2016). Accumulation of ROS has long been shown to play a vital role in mediating apoptosis among differ-ent cell types (Pierce et al, 1991) via mitochondrial and nonmitochondrial dependent pathways (Sinha et al, 2013).…”

Section: Discussionsupporting

confidence: 89%

Oxidative stress involvement in chronic chlorpyrifos-induced hepatocellular injury: Alleviating effect of vitamin C

2018

Savannah Vet J

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Introduction: Chlorpyrifos (CPF), a phosphorothionate chlorinated organophosphate (OP) insecticide is widely used in agriculture and public health. Like other OP insecticides, its main mechanism of toxicity is the inhibition of acetylcholinesterase (AChE) leading to cholinergic syndrome. Since toxicity occurs at doses that do not inhibit AChE or long after its restoration, other mechanisms including the induction of oxidative stress have been widely implicated. The present study was aimed at evaluating the mitigating effect of vitamin C on CPF-induced hepatocellular injury in Wistar rats. Methods: Twenty adult male Wistar rats were divided into 4 groups of five animals in each group. The four groups were exposed by gavage to soya oil (2 ml/kg), vitamin C (100 mg/kg), CPF (10.6 mg/kg~1/8th LD50) and vitamin C (100 mg/kg) + CPF (10.6 mg/kg; 30 min later), respectively for 17 weeks. The sera obtained from blood samples collected from the animals were analysed for the levels of total proteins, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), g-glutamyl transferase (GGT) while globulin concentration and albumin/globulin ratio were calculated. The liver homogenate was evaluated for the levels of malonaldehyde (MDA), superoxide dismutase (SOD) and catalase (CAT), and histological changes. Results: The study showed that CPF altered the levels of the serum hepatic enzymes, hepatic MDA SOD and CAT, in addition to inducing hepatocellular degeneration. All these parameters were alleviated by pretreatment with vitamin C. Significance: CPF-induced hepatocellular injury which was partly due to oxidative changes was mitigated by vitamin C partly due to its antioxidative activity.

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Section: Discussionsupporting

confidence: 89%

Oxidative stress involvement in chronic chlorpyrifos-induced hepatocellular injury: Alleviating effect of vitamin C

2018

Savannah Vet J

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“…Wang et al (2009) stated that chlorpyrifos is generally toxic to mammals. Exposure to CPF induced histopathological alterations in liver (Tripathi and Srivastav, 2010) and kidney (Heikal et al2012). Human and experimental studies have shown that fetuses and infants are more sensitive than adults to many environmental toxicants including chlorpyrifos and these exposures impact fetal growth and early childhood neurodevelopment (Eskenazi et al2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of Selenium on Chlorpyrifos-Induced Thyroid Toxicity in Albino Rats

Lamfon¹

2014

ENDO

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The present work studied the effect of the organophosphate insecticide, Chlorpyrifos (CPF) on the thyroid of albino rats and the possible ameliorative role of selenium (Se). Administration of CPF by gastric intubation (1/20 LD50, 6.7 mg/kg b.w. 5 days / week for 6 weeks) caused many histological alterations in the thyroid There was decrease in the size of follicles and amount of colloid, degeneration of follicular cells and congestion of blood vessels. Decrease of periodic acid Schiff (PAS) reaction in the cytoplasm of the follicular cells and colloids was observed. Besides, CPF caused marked reduction in triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH). Animals treated with CPF and Se ((10 µg/Kg b.w, 5 days / week for 6 weeks) showed great amelioration and normalization of thyroid tissue architecture and increase in the thyroid hormones, T3, T4 and TSH. Since CPF toxicity may be due to its ability to induce oxidative stress in thyroid, it is possible that Se supply reversed CPF-induced thyroid toxicity by ameliorating the antioxidative defense of the rats.

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“…[5] Organophosphates (OP) pesticide are widely used in agriculture, industry and public health due to their high insecticidal activity, low environmental stability and moderate toxicity. [6] However, the frequent use of OP pesticide and accessibility have increased their risk. [7] MethidathionS-(2,3-Dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl) O,O-dimethyl phosphorodithioate, is one of the most widely OP pesticide used in the world for pest control of crop [8] , The department of pesticide regulation (DPR) Environmental Protection Agency placed methidathion on high-priority roster for risk and its value based on the conceivable adverse effects in chronic toxicity, carcinogenesis and chromosomal anomalies.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

The Effect of Methidathion on Sex Hormones, Sperm Parameters and Testicular Tissue in Mice

Rahi¹

2017

WJPR

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The present study aimed to identify the effect of methidathion on sex hormones, sperm parameters and testicular tissue in mice Mus musculus. Adult male mice divided into three groups (8 for each group), the first group i.p injected with normal saline as a control group, the second and third groups were i.p injected with (1.2, 2.4mg/kg of body weight) methidathion respectively for 15 day. The level of LH wasreduced in mice given high dose methidathion and decrease levels of testosterone in low and high doses compared with control group.A significant decreased in number of sperm after methidathion injection and significant increased in proportion of malformation sperm rate shown in high dose compared with control group. histopathological examination of testes showed analysis in some seminiferous tubules.

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Liver profile of rats after long-term ingestion of different doses of chlorpyrifos

Cited by 36 publications

References 31 publications

Oxidative stress involvement in chronic chlorpyrifos-induced hepatocellular injury: Alleviating effect of vitamin C

Oxidative stress involvement in chronic chlorpyrifos-induced hepatocellular injury: Alleviating effect of vitamin C

Effect of Selenium on Chlorpyrifos-Induced Thyroid Toxicity in Albino Rats

The Effect of Methidathion on Sex Hormones, Sperm Parameters and Testicular Tissue in Mice

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