Serum Antioxidant Vitamin Levels in Patients with Coronary Heart Disease

Abstract

The aim of this study was to investigate anthropometric measurements, body composition, and serum antioxidant vitamin levels in men with coronary heart disease (CHD). Thirty-five men with CHD and 31 men without CHD, aged 40 - 65 years, were included this study. Dietary records and anthropometric measurements of each participant were recorded by researchers and serum antioxidant vitamin levels and lipid profiles were analyzed. Fat mass (FM) and the percentage of fat mass (FM%) in men with CHD was higher than in men without CHD (p < 0.05). Lipid profiles were found to be similar in both groups, with the exception of high-density lipoprotein cholesterol (HDL-C). Men with CHD had lower HDL-C levels than men without CHD (p < 0.05). When the antioxidant vitamin intake of participants was investigated, vitamin E intake in men without CHD was found to be less than in men with CHD (p < 0.05). However, serum vitamin A, vitamin E, and vitamin C levels in men with CHD were found to be lower than in men without CHD (p < 0.05). Based on the results of this study, we propose that high FM, low HDL-C, and low serum antioxidant vitamin levels could be important risk factors for CHD.

Comparative Study of Levels of Selective Oxidative Stress Markers (Malondialdehyde, Zinc, and Antioxidant Vitamins A, E, and C) in Ischemic and Non-Ischemic Heart Disease Patients Suffering From Type- 2 Diabetes

“…The results of the study also indicated a highly significant increase in the levels of serum antioxidant Vitamins A and E of patients with IHD and the patient's group without heart disease. Our findings are in agreement with those of other authors who showed serum Vitamin A and Vitamin E levels in patients with chronic heart disease were found to be lower than without heart disease [11][12][13]. On the other hand, some reports indicate that no significant changes occur in patients with heart disease when compare to patients without heart disease [14,15].…”

Circulating tocopherols and risk of coronary artery disease: A systematic review and meta-analysis

“…According to our searching strategies, we got 24 studies involving a total of 6541 participants, which provided sufficient data for the calculation of difference in α-tocopherol or total tocopherols level between CAD patients and controls. Of these studies, there were 20 case–control studies 15–20, 30–43 and four nested case–control studies. 12,44–46 There were 15 studies from Asia, 12,15,17,19,20,32,34–41,46 seven from Europe, 16,18,30,33,42,43,45 one from Africa 31 and one from North America.…”

“…Sex ratio was treated as continuous variable and not available in the study by Yildiran et al. 19 (all male).…”

“…Although many studies have been conducted to explore the association between serum level of tocopherols and the risk of CAD in the past decades, their results were inconsistent. 15–20 As a result, whether circulating tocopherols were protective factors against CAD remained unknown. No meta-analysis focused on this topic had been published before.…”

The relation of serum vitamins C and E levels and the severity of angiographically defined coronary artery disease in Alsader Teaching Hospital in Basrah

“…The current study demonstrated significantly a lower serum level of αtocopherol among CAD patients than the control group (Table-4), which agreed with other studies. [18][19][20][21] However, other researchers (Frki, et al (2000) [22] and (Tavallaie, et al (2012) [23] found that there was no statistical difference in the level of vitamin E between CAD and non CAD patients. This low vitamin E could be due to over consumption of antioxidants or low dietary intake.…”