Comparative Study of Levels of Selective Oxidative Stress Markers (Malondialdehyde, Zinc, and Antioxidant Vitamins A, E, and C) in Ischemic and Non-Ischemic Heart Disease Patients Suffering From Type- 2 Diabetes

Abstract

Objective: The objective of the current study is to compare the levels of oxidative stress markers malondialdehyde (MDA), zinc, and antioxidant Vitamins (A, E, and C) in ischemic heart disease (IHD) and non-IHD patients with diabetes mellitus.Method: This is cross-sectional study group, conducted in the advanced diagnostic center (Khartoum- Sudan) from the period May 2013 to August 2015. Comprised 100 healthy subjects were, control group with mean (fasting blood sugar) 5.61=m mol/L, the age ranged from 22 to 78 years old, the average of the age was 50.1 years. 300 patients (78 IHD and 222 without) as cases groups, the ages ranged from 30 to 80 years. The age average was 51.2 years, all samples were in a state of fasting for 12 h, and the data were collected using a structured questionnaire and direct interview to collect information. Blood specimens were collected from both groups, and plasma levels of MDA, zinc, and antioxidant Vitamins (A, E, and C) were determined.Results: There was a significant difference between the level of serum Vitamin A, E, and MDA in diabetic patients with IHD and those diabetic without IHD (p<0.05). No significant differences in serum Vitamin C level between both groups (p>0.05).Conclusion: Due to the significant differences in serum Vitamin A, E, Zinc, and MDA between diabetics with IHD and diabetics without IHD, these parameters can be used as prognostic markers for prediction of oxidative stress and antioxidant stress of diabetic patients with IHD complications.

Changes in blood and urine parameters among pregnant women during third trimester

“…11 In addition to that, the present study indicated significantly strong positive correlation between HbA1% and estimated Average glucose (r=0.78, P value =0.00) this in same with study done by Shobha. 13,14 The average plasma blood glucose corresponding to HbA1c% value of 5% is 101 mg/dl and that corresponding to mean value of 5.29% is 111 mg/dl (range for 5.29%±0.514% is 90-129 mg/dl) hence, it may be concluded that HbA1c can indeed be utilized for the monitoring of glycemic level, as a screening test, even in nondiabetic pregnancies. The correlation coefficient between HbA1c% and blood glucose is 0.80.…”

Effectiveness of Some Vitamins in the Prevention of Cardiovascular Disease: A Narrative Review

“…Prolonged use of vitamin A was also observed to reduce atherosclerosis in both animals and patients as a consequence of its antioxidant and antiinflammatory actions (Ozkanlar and Akcay, 2012;Ruiz-León et al, 2019). Supplementation of vitamin A was reported to lower the oxidative stress level in diabetic patients with ischemic heart disease (Altoum et al, 2018). Ischemia-reperfusion (I/R) induced infract size was reduced and the post-ischemic cardiac function recovery was improved by β-carotene in Zucker diabetic rats (Csepanyi et al, 2018), Furthermore, treatment with β-carotene protected the myocardium from advance glycation end productinduced SR stress, apoptosis and autophagy (Zhao et al, 2020).…”

Antioxidant enzymes and vascular diseases

“…Although data from studies with experimental animal models advocate the protective role of antioxidants versus vascular disorders [83][84][85][86], data from clinical trials are not conclusive [56,87]. For example, vitamin A has been rated as a beneficial supplement that may reduce OxS in diabetic individuals with ischemic heart disease [88]. Melatonin supplementation may reduce myocardial ischemic-reperfusion injury in male and female patients undergoing coronary artery bypass [89].…”