Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria

Fitri, Loeki Enggar; Iskandar, Agustin; Sardjono, Teguh Wahju; Erliana, Ummu; Rahmawati, Widya; Candradikusuma, Didi; Saputra, Utama Budi; Suhartono, Eko; Setiawan, Bambang; Sulistyaningsih, Erma

doi:10.1016/j.apjtb.2016.06.003

Cited by 11 publications

(7 citation statements)

References 12 publications

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“…In addition, as we all know, l - glutamate plays an important role in protein metabolism and participates in many important biochemical reactions. Furthermore, l - glutamate can be converted into l - glutamine and can also combine with cysteine and glycine to form glutathione (GSH), which has antioxidant and detoxification effects and helps maintain normal immune system function. , When F. graminearum was treated with compound E8 at 10 μg·mL –1 , the differential metabolites related to l - glutamate, l - glutamine, and glutathione were significantly upregulated (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the GSSG/GSH ratio is an important and stable biological indicator reflecting the status of the thiol redox homeostasis. An increased GSSG/GSH ratio has been suggested to be an important contributing factor to many stress responses. , From the analysis of differential metabolites, F. graminearum may resist the drug-treated stress through the metabolic pathways related to l - glutamate, l - glutamine, and glutathione.…”

Section: Resultsmentioning

confidence: 99%

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Natural Alkaloid Waltherione F-Derived Hydrazide Compounds Evaluated in an Agricultural Fungicidal Field

Chen

Fang

Chang

et al. 2023

J. Agric. Food Chem.

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In this project, quinoline and quinolone-containing hydrazide compounds were designed and synthesized by introducing a bioactive hydrazide group into the skeleton of waltherione F. The fungicidal activity revealed that some hydrazide compounds exhibited excellent and broad-spectrum fungicidal activity; especially, compounds E8, E12, and E16 showed more than 90% or even 100% inhibition rates against most pathogens at 50 μg•mL −1 . The fungicidal mechanism indicated that compound E8 may affect the normal function of the plasma membrane, further generating changes in the morphology and subcellular structure of mycelia. Simultaneously, Fusarium graminearum may resist the E8-treated stress through the metabolic pathways related to Lglutamate, L-glutamine, and glutathione. Finally, the effect of compound E8 on wheat seedling's growth and the toxicity to zebrafish were accomplished. These results will provide important guidance to discover novel fungicidal lead compounds and explore new targets, which are effective ways to alleviate the increasingly severe drug resistance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Natural Alkaloid Waltherione F-Derived Hydrazide Compounds Evaluated in an Agricultural Fungicidal Field

Chen

Fang

Chang

et al. 2023

J. Agric. Food Chem.

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“…However, this is significantly lower than glutathione concentrations found in human serum and the linear range tends to be lower so samples must be diluted for those sensors. The linear range of our sensor is appropriate for determining glutathione in serum which has been shown to be ~80 µM in healthy patients [ 19 ]. This sensor makes it possible to determine concentrations both above and below the typical amount.…”

Section: Resultsmentioning

confidence: 99%

“…Over the same concentration range for the buffer tests, the sensor shows a linear response to glutathione with a sensitivity of 22.1 ± 0.3 µA cm −2 Mm −1 and a limit of detection of 43 µM. This linear range is appropriate for determining glutathione in serum which has been shown to be ~80 µM in healthy patients [ 19 ]. This sensor makes it possible to determine concentrations both above and below the typical amount.…”

Section: Resultsmentioning

confidence: 99%

A Self-Powered Biosensor for the Detection of Glutathione

et al. 2020

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Glutathione is an important biological molecule which can be an indicator of numerous diseases. A method for self-powered detection of glutathione levels in solution has been developed using an enzymatic biofuel cell. The device consists of a glucose oxidase anode and a bilirubin oxidase cathode. For the detection of glutathione, the inhibition of bilirubin oxidase leads to a measurable decrease in current and power output. The reported method has a detection limit of 0.043 mM and a linear range up to 1.7 mM. Being able to detect a range of concentrations can be useful in evaluating a patient’s health. This method has the potential to be implemented as a quick, low-cost alternative to previously reported methods.

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“…When chronic oxidative stress attacked certain tissue, as proposed in osteoporosis pathogenesis, it would lead to buffer changes through large increasing GSSG levels due to the inability of cells to reduce GSSG back to GSH as effectively normal. 9,10 Thus, GSH/GSSG ratio would decrease as well. This might explain why there was significant correlation between GSH/ GSSG ratio and BMD in this study (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women

Jusup

Batubara

Ngestiningsih

et al. 2021

Mol Cell Biomed Sci

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Background: Osteoporosis is one of chronic degenerative diseases especially in postmenopausal women, characterized by a decreased bone mass due to imbalance activity between osteoblasts and osteoclasts. Recently, oxidative stress is believed to play an important role in osteoporosis pathogenesis. Oxidative stress is commonly considered as the consequence of an imbalance between pro and antioxidants species, which results in damage in the affected tissue. Malondialdehyde (MDA) is frequently used as a biomarker of oxidative stress in many health problems since MDA is produced at high levels during lipid peroxidation. Meanwhile, glutathione is well known as one of antioxidant which against oxidative stress by preserving its homeostasis in the reduced form of glutathione sulfhydryl (GSH) and the oxidized form of glutathione disulphide (GSSG). This study was aimed to determine the association between MDA, GSH/GSSG ratio and bone mineral density (BMD) in postmenopausal women.Materials and method: We conducted a cross-sectional study in 40 postmenopausal women. MDA and GSH/GSSG ratio were assessed by enzyme-linked immunosorbent assay (ELISA). Bone mineral density (BMD) was obtained from secondary data. The statistical analysis was conducted using Spearman rho’s correlation test.Results: Based on the test, we didn’t found significant correlation between MDA and BMD (r=-0.054, p=0.741), but we found significant moderate correlation between GSH/GSSG ratio (r=0.436, p=0.005) and BMD in postmenopausal women. Conclusion: There was no correlation between MDA and BMD in postmenopausal women. However, there was significant moderate correlation between GSH/GSSG ratio and BMD in postmenopausal women.Keywords: MDA, GSH/GSSG ratio, BMD, osteoporosis

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Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria

Cited by 11 publications

References 12 publications

Natural Alkaloid Waltherione F-Derived Hydrazide Compounds Evaluated in an Agricultural Fungicidal Field

Natural Alkaloid Waltherione F-Derived Hydrazide Compounds Evaluated in an Agricultural Fungicidal Field

A Self-Powered Biosensor for the Detection of Glutathione

Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women

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