Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women

Jusup, Innawati; Batubara, Lusiana; Ngestiningsih, Dwi; Fulyani, Faizah; Paveta, Devina Afraditya; Bancin, Putri Theresia Lemmo Ate

doi:10.21705/mcbs.v5i1.157

Cited by 3 publications

(3 citation statements)

References 6 publications

(8 reference statements)

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“…Regarding cellular antioxidant enzymes, a significant correlation between decreasing GSH/GSSG and bone mineral destiny (BMD) was reported in postmenopausal women [ 98 ]. Accordingly, GSH/GSSG ratios were significantly lower in chondrocytes isolated from elderly donors as compared to cell derived from young donors [ 99 ].…”

Section: The Cellular Antioxidant Defense Systemmentioning

confidence: 99%

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

Riegger,

Schoppa,

Ruths

et al. 2023

Cell Mol Biol Lett

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During aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, and proinflammatory cytokines. This detrimental environment triggers cellular stress and subsequent dysfunction, which not only contributes to the development of associated diseases, that is, osteoporosis and osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated stress and reduce the overall tissue damage, cells possess diverse defense mechanisms. However, cellular antioxidative capacities are limited and thus ROS accumulation can lead to aberrant cell fate decisions, which have adverse effects on cartilage and bone homeostasis. In this narrative review, we address oxidative stress as a major driver of pathophysiologic processes in cartilage and bone, including senescence, misdirected differentiation, cell death, mitochondrial dysfunction, and impaired mitophagy by illustrating the consequences on tissue homeostasis and regeneration. Moreover, we elaborate cellular defense mechanisms, with a particular focus on oxidative stress response and mitophagy, and briefly discuss respective therapeutic strategies to improve cell and tissue protection.

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Section: The Cellular Antioxidant Defense Systemmentioning

confidence: 99%

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

Riegger,

Schoppa,

Ruths

et al. 2023

Cell Mol Biol Lett

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“…31 PUFA forms peroxyl radicals (ROO•) by reacting with oxygen, propagating chain reaction and leading to LPO. 32 We observed a significant decrease in LPO in all CPMSEtreated groups.…”

Section: Discussionmentioning

confidence: 54%

Hypoglycaemic, Hypolipidaemic and Antioxidant Properties of Celastrus paniculatus Seed Extract in STZ-induced Diabetic Rats

Ahmad

Haidar

Naseem

et al. 2023

Mol Cell Biomed Sci

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Background: Celastrus paniculatus is a herb used in the Ayurvedic system of medicine that has been reported to show multiple pharmacological properties. In this study, we explored the antioxidative, hypolipidaemic and hypoglycaemic potential of C. paniculatus methanolic seed extract (CPMSE) in high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats.Materials and methods: Seeds of C. paniculatus were extracted in methanol using Soxhlet extraction method. A total of 36 rats were induced with STZ and HFD and treated with glibenclamide or various concentrations of CPMSE. Upon treatment, blood samples were collected and kidney and liver samples were homogenised. Serum biochemical estimation was performed using several diagnostic kits. Protein was estimated by bicinchoninic acid (BCA) method. Oxidative stress was assessed by measuring malondialdehyde level and superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) activity.Results: CPMSE caused improvements in glucose homeostasis, lipid profile, liver function and oxidative stress parameters in a dose-dependent manner. CPMSE significantly decreased the levels of fasting blood glucose and glycated haemoglobin as well as increased insulin level and total protein content. There was an increase in total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), triglycerides (TG) levels and reduction in high density lipoprotein-cholesterol (HDL-C) level. There was a decrease in serum levels of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP). CPMSE decreased LPO and increased CAT, SOD and GST activity.Conclusion: CPMSE has hypoglycaemic, hypolipidaemic and antioxidant properties by reducing the oxidative stress.Keywords: diabetes mellitus, Celastrus paniculatus, antioxidant, phytochemicals, phytonutrients, streptozotocin, high-fat diet

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“…No. E0156Ra, Elabscience, Texas, USA) and according to the procedure performed by Jusup et al (2021) 29 .…”

Section: Malondialdehyde (Mda) Measurementmentioning

confidence: 99%

The Effect of Alpha Lipoic Acid (ALA) Supplementation on the in Vitro Maturation Media of Goat Oocyte on Tumor Alpha Necrosis Factor (TNF-α) Expression and Malondialdehyde (MDA) Levels

Al-Anshori¹,

Mustofa²,

Safitri³

et al. 2023

International Journal of Scientific Advances

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This study aimed to determine the effect of Alpha Lipoic Acid (ALA) supplementation on in vitro maturation media of goat oocytes on Tumor Necrosis Factor Alpha (TNF-α) expression and Malondialdehyde (MDA) levels. This laboratory experimental study consisted of three treatment groups: control group (G0), 25 μmol/L ALA supplementation (G1), and 50 μmol/L ALA supplementation (G2). A total of 366 goats Cumulus Oocyte Complex (COCs) were collected, then selected into 216 COCs, and matured in vitro for 22 hours in a 5% CO2 incubator, 98% humidity, 38.50C temperature. After that, TNF-α expression was identified using Immunocytochemistry staining with the addition of TNF-α antibody and calculated using the Remmele Scale Index. Measurement of MDA levels using the ELISA method. The data obtained were analyzed using Kruskal-Wallis, One Way ANOVA, and Duncan’s in the SPSS 24 software program (p<0.05). The expression value of TNF-α G0 was 0.75±1.39, G1 was 5.56±3.05, and G2 was 2.00±1.80. MDA levels of G0 were 26.52 ±2.92, G1 was 46.44 ±4.87, and G2 was 30.41±5.67. TNF-α expression data and MDA levels G0 and G2 didn’t show a significant difference, while G0 and G2 compared to G1 showed a significant difference (p<0.05). ALA supplementation of 25 µmol/L increased TNF-α expression or MDA levels and 50 µmol/L on in vitro maturation media of goat oocytes could reduce TNF-α expression or MDA levels than 25 µmol/L.

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Association between Malondialdehyde, GSH/GSSG Ratio and Bone Mineral Density in Postmenopausal Women

Cited by 3 publications

References 6 publications

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

Hypoglycaemic, Hypolipidaemic and Antioxidant Properties of Celastrus paniculatus Seed Extract in STZ-induced Diabetic Rats

The Effect of Alpha Lipoic Acid (ALA) Supplementation on the in Vitro Maturation Media of Goat Oocyte on Tumor Alpha Necrosis Factor (TNF-α) Expression and Malondialdehyde (MDA) Levels

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