Background: Osteoporosis is one of chronic degenerative diseases especially in postmenopausal women, characterized by a decreased bone mass due to imbalance activity between osteoblasts and osteoclasts. Recently, oxidative stress is believed to play an important role in osteoporosis pathogenesis. Oxidative stress is commonly considered as the consequence of an imbalance between pro and antioxidants species, which results in damage in the affected tissue. Malondialdehyde (MDA) is frequently used as a biomarker of oxidative stress in many health problems since MDA is produced at high levels during lipid peroxidation. Meanwhile, glutathione is well known as one of antioxidant which against oxidative stress by preserving its homeostasis in the reduced form of glutathione sulfhydryl (GSH) and the oxidized form of glutathione disulphide (GSSG). This study was aimed to determine the association between MDA, GSH/GSSG ratio and bone mineral density (BMD) in postmenopausal women.Materials and method: We conducted a cross-sectional study in 40 postmenopausal women. MDA and GSH/GSSG ratio were assessed by enzyme-linked immunosorbent assay (ELISA). Bone mineral density (BMD) was obtained from secondary data. The statistical analysis was conducted using Spearman rho’s correlation test.Results: Based on the test, we didn’t found significant correlation between MDA and BMD (r=-0.054, p=0.741), but we found significant moderate correlation between GSH/GSSG ratio (r=0.436, p=0.005) and BMD in postmenopausal women. Conclusion: There was no correlation between MDA and BMD in postmenopausal women. However, there was significant moderate correlation between GSH/GSSG ratio and BMD in postmenopausal women.Keywords: MDA, GSH/GSSG ratio, BMD, osteoporosis

Background: Low zinc levels affects the relationship between the glutamatergic and serotonergic systems in major depressive disorders that cause stress and inflammation. Decreased zinc in the hippocampus can activates the HPA axis associated with an increase in cortisol. Several studies documented the relationship between zinc and clinical depression, however further research including biological measurements is needed to support these studies.Objective: To observe the correlation between zinc intake with serotonin and cortisol serum in patient with depressionMethods: This was an observational study with cross sectional design. Subjects were patients with depression who came to Dr. Kariadi Hospital, Tugurejo Hospital, Diponegoro National Hospital and Permata Medika Hospital met the inclusion and exclusion criteria. The food frequency questionnaire (FFQ) was used to assess daily zinc intake. The levels of serum serotonin and cortisol were measured using ELISA technique.Results: Of the 53 subjects, there was significant correlation between zinc intake with serotonin serum level (p=0,038), however there was no correlation between zinc intake with cortisol serum level (p=0,845)Conclusion: The higher zinc intake the higher serotonin serum level, however there was no correlation between zinc intake with cortisol serum level in patients with depression.

Background: Based on data from WHO in 2015, it shows that the death rate due to suicide in the world was recorded to have increased by 23.2% compared to 2009. Research in 2016 shows that the largest age range who experienced suicide was from 15-29 years. Many things are predicted to be a protective factor against suicide, including social support. Research on suicide protection factors is useful in preventing the increasing number of suicides.Objective: To analyze the correlation between perceived social support with suicidal ideationMethods: This research is a quantitative study with cross sectional design. Samples were taken from vocational school and academy in Semarang, who met the inclusion and exclusion criterias. The sample selection was carried out by the simple random sampling method. This research used the Indonesian version of the SSI (Scale of Suicide Ideation) and the MSPSS (Multidimentional Scale of Perceived Social Support) questionnaires.Results: It was found that the prevalence of high suicidal ideation score was 50.8% while the low suicidal ideation score was 49.2%. There was a significant correlation between suicidal ideation with perceived of family support (p = 0.002) and peer support (p = 0.050). Meanwhile, there was no significant correlation between the suicidal ideation and the support from significant others (p = 0.154). Conclusion: There was a correlation between perceived of family and peer support with suicidal ideation

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Background: Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) are increased in tissue damage. Ashitaba contains many compounds that can reduce serum SGOT and SGPT levels. Objective: This study was proposed to prove that giving Ashitaba extract could reduce serum SGOT and SGPT levels in rats exposed to burn injury. Methods: This study used a posttest only control group design with 20 rats as samples. All research samples were treated with second-degree burns and were divided into 2 different groups, the treatment group (given Ashitaba extract 300 mg /kg BW) and the control group. The blood serum was analyzed for SGOT and SGPT test on the 2nd, 8th, and 14th days. For statistical analysis, the Wilcoxon test used to analyze the levels of serum SGOT and SGPT. Results: There was no significant difference in serum SGOT and SGPT levels between the control and treatment groups on the 2nd, 8th, and 14th days Conclusion: Ashitaba extract could not reduce serum SGOT and SGPT levels in rats exposed to burn injury.

Background: Older adults are susceptible to worsened quality of life (QOL) and depression due to aging. Elderly integrated health service post (EIHSP) is community-based health care that aims to improve older adults’ health; however, not all older adults participate in this health service.Purpose: This study was conducted to assess the relationship between the QOL, depression level, and older adults’ participation in EIHSP.Methods: A cross-sectional study was carried out among 102 older adults in a community-dwelling area in Semarang, Indonesia. Respondents were recruited using a total sampling technique. QOL was assessed by the WHOQOL-BREF questionnaire, while the level of depression was assessed by Geriatric Depression Scale (GDS) questionnaires. Descriptive statistics, Spearman, and Sommers’ d tests were used to analyze the data.Results: Higher participation in EIHSP significantly affected QOL on every domain (general quality of life, physical, psychological, social relationship, and environmental domains) with p<0.05. This study also showed that participation in EIHSP had a significant relationship with depression levels (p=0.002). Furthermore, higher depression levels significantly affected QOL on every domain (p<0.05).Conclusion: This study showed that older adults’ participation in EIHSP had a significant relationship with QOL and depression. Community nurses can promote the utilization of EIHSP among older adults for better physical and mental health. Future studies should investigate these relationships in a larger sample size.

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ABSTRAK   LATAR BELAKANG : Skizofrenia merupakan gangguan mental dengan mortalitas dua sampai tiga kali lipat lebih tinggi dibandingkan populasi umum. Antispikotik generasi kedua merupakan salah satu terapi untuk skizofenia, namun memiliki efek samping gangguan metabolik yang lebih tinggi dibandingkan antipsikotik golongan pertama, seperti peningkatan kadar gula darah.   TUJUAN : Mengetahui perbedaan kadar gula darah sewaktu pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua selama kurang dari empat bulan dan lebih dari empat bulan.   METODE : Penelitian ini merupakan penelitian observasional analitik dengan desain potong lintang. Sampel adalah data rekam medis 67 pasien skizofrenia di RSJD Amino Gondohutomo Semarang yang memenuhi kriteria inklusi. Subjek dibagi menjadi dua kelompok yaitu yang mendapatkan terapi kurang dari 4 bulan dan yang mendapatkan terapi selama lebih dari 4 bulan. Uji statistik menggunakan uji Mann Whitney untuk mengetahui perbedaan antara kedua kelompok. HASIL :  Kadar gula darah sewaktu pada kelompok yang mendapat terapi antipsikotik generasi kedua selama kurang dari empat bulan lebih rendah (116 mg/dl) dibandingkan dengan yang mendapatkan terapi lebih dari  empat bulan  (118 mg/dl). Meskipun demikian, perbedaan tersebut tidak bermakna secara statistik (p>0.05).   KESIMPULAN : Tidak terdapat perbedaan kadar gula darah sewaktu pada pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua kurang dari empat bulan dan lebih dari empat bulan.   Kata Kunci    : skizofrenia, antipsikotik, gula darah sewaktu