Pathological, Immunohistochemical and Bacteriological Study of Tissues and Milk of Cows and Fetuses Experimentally Infected with Brucella abortus

Xavier, Mariana N.; Paixão, Tatiane Alves da; Poester, Fernando Padilla; Lage, Andrey Pereira; Santos, Renato L.

doi:10.1016/j.jcpa.2008.10.004

Cited by 155 publications

(200 citation statements)

References 22 publications

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“…These differences reflect the fact that Minas Gerais has 5.6 million milking cows that generates approximately 8.7 billion of litters of milk annually (IBGE 2011), whereas Tocantins has only 0.4 million milking cows, producing 0.2 billion of litters of milk annually. Importantly, although the most important clinical manifestation of bovine brucellosis is abortion and perinatal mortality (Carvalho Neta et al 2010, Xavier et al 2009b), losses associated with abortion and perinatal mortality do not correspond to a major fraction of the losses in any of the states studied (Fig.3).…”

Section: Discussionmentioning

confidence: 98%

“…In cattle, brucellosis is mostly caused by B. abortus infection (Poester et al 2013), and it is characterized by abortions during the last trimester of gestation, perinatal mortality, and infertility, whereas bulls can develop orchitis (Carvalho Neta et al 2010, Poester et al 2013. Importantly high bacterial loads are present in aborted fetuses and fetal membranes (Xavier et al 2009b), favoring transmission within the herd. In addition, B. abortus infection is associated with interstitial, often subclinical, mastitis that is associated with shedding of the organism in the milk (Xavier et al 2009b), which poses a health hazard for human consumption of unpasteurized dairy products.…”

Section: Introductionmentioning

confidence: 99%

“…Importantly high bacterial loads are present in aborted fetuses and fetal membranes (Xavier et al 2009b), favoring transmission within the herd. In addition, B. abortus infection is associated with interstitial, often subclinical, mastitis that is associated with shedding of the organism in the milk (Xavier et al 2009b), which poses a health hazard for human consumption of unpasteurized dairy products.…”

Section: Introductionmentioning

confidence: 99%

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Economic losses due to bovine brucellosis in Brazil

et al. 2013

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Pesq. Vet. Bras. 33(6):759-764, junho 2013 759 RESUMO.-[Perdas econômicas devidas à brucelose bovina no Brasil.] A brucelose é uma zoonose de importân-cia mundial. Recentes dados epidemiológicos dessa doença foram obtidos por meio de estudos que abrangeram em torno de 90% do rebanho bovino do Brasil. Observa--se escassez de informações sobre o impacto econômico causado pela brucelose bovina, portanto, o objetivo do presente estudo foi estimar as perdas econômicas na pecuária brasileira. Gastos relacionados com as ocorrências de abortos, natimortos, subfertilidade, descartes involuntários, mortalidade, intervenções veterinárias, diminuição da produção de leite e de carne, foram considerados nos cálculos. As perdas devidas à brucelose bovina no Brasil foram estimadas em R$ 420,12 ou R$ 226,47 para cada fêmea infectada acima de 24 meses de idade em rebanhos de leite Brucellosis is an important zoonosis of worldwide distribution. Reliable epidemiologic brucellosis data covering approximately 90% of the cattle population in Brazil have been recently published. Therefore, considering the scarcity of information regarding the economic impact of bovine brucellosis in Brazil, the goal of this study was to estimate economic impact of brucellosis on the Brazilian cattle industry. Several parameters including abortion and perinatal mortality rates, temporary infertility, replacement costs, mortality, veterinary costs, milk and meat losses were considered in the model. Bovine brucellosis in Brazil results in an estimated loss of R$ 420,12 or R$ 226,47 for each individual dairy or beef infected female above 24 months of age, respectively. The total estimated losses in Brazil attributed to bovine brucellosis were estimated to be approximately R$ 892 million (equivalent to about 448 million American dollars). Every 1% increase or decrease in prevalence is expected to increase or decrease the economic burden of brucellosis in approximately 155 million Reais.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Economic losses due to bovine brucellosis in Brazil

et al. 2013

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“…Além disso, tem sido sugerido que os linfonodos que drenam as áreas de infecção ou de lesões têm maior chance de serem positivos para B. abortus (Forbes et al 1989, Palmer et al 1996. Xavier et al (2009), verificaram que em vacas prenhes, experimentalmente infectadas por B. abortus, os principais locais onde isolaram a bactéria foram os linfonodos mamários e a glândula mamária. Os achados do presente trabalho são semelhantes aos encontrados por Adesiyun et al (2010), que isolaram B. abortus a partir de homogeneizados de linfonodos parotídeos e pré-escapulares de búfalos com 3 a 6 meses de idade, locais próximos ao local de inoculação da bactéria, que foi por via intraconjuntival.…”

Section: Discussionunclassified

Detecção de Brucella abortus em linfonodos de búfalas (Bubalus bubalis) em diferentes fases da gestação

et al. 2015

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The objective of this study was to detect Brucella abortus in lymph nodes of buffaloes as well as to describe the lesions caused. Nineteen buffalo cows in various stages of pregnancy, serologically positive for brucellosis and subjected to culling were used. Fetal age was determined by ultrasound examination and the size of fetuses was measured at necropsy. Fragments of lymph nodes were collected for histopathology and qPCR. The detection of B. abortus DNA in the lymph nodes was checked from the fourth month of pregnancy in seven buffaloes and in a post-calving buffalo. Acute to chronic lymphadenitis was histologically diagnosed. B. abortus DNA was detected in all evaluated groups of lymph nodes; the mammary lymph nodes were the most affected.

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“…In addition to abortion, the disease may also cause stillbirths, birth of weak calves, placental retention, temporary or permanent infertility, perinatal mortality, and chronic or diffuse interstitial mastitis, among other problems (CORBEL, 2006;LAGE et al, 2008;XAVIER et al, 2009;POESTER et al, 2013). In males, infection can cause orchitis, epididymitis, decrease spermatozoa quality, and subfertility or sterility (CAMPERO, 1990;LAGE et al, 2008;POESTER et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors for bovine brucellosis in Minas Gerais State, Brazil

Oliveira¹,

Dorneles²,

Mota³

et al. 2016

Semin: Ciênc. Agrár.

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This cross-sectional study was conducted in the state of Minas Gerais, Brazil in 2011 to estimate the seroprevalence of bovine brucellosis (Brucella abortus) in properties and cattle, and to identify potential infection risk factors for herds with cows of reproductive age. The state was divided into seven regions: 1. Noroeste, Norte and Nordeste; 2. Leste; 3. Central; 4. Zona da Mata; 5. Sul and Sudoeste; 6. Alto Paranaíba; and 7. Triângulo Mineiro. Random, two-stage sampling was performed of both properties and cattle from each property. Blood samples were collected from 18,990 cows of reproductive age from 2,185 properties. The serologic tests used for the detection of anti-B. abortus antibodies included the buffered, acidified plate antigen test, as a screening test, with the 2-mercaptoethanol reduction, test as a confirmatory test, as recommended by the Programa Nacional de Controle e Erradicação da Brucelose e Tuberculose Animal -PNCEBT (National Program for the Control and Eradication of Animal Brucellosis and Tuberculosis). The seroprevalence of bovine brucellosis on the surveyed properties and in cattle were 3.59% (95% confidence interval [CI]: 2.76 4.42%) and 0.81% (95% CI: 0.05-1.10%), respectively. Multiple logistic regression analysis identified the total number of cows in the property as a risk factor for the presence of anti-B. abortus antibodies, with an odds ratio (OR) of 1.93 (95% CI: 1.12 -3.34) for herds with 30 to 210 cows and 7.81 (95% CI: 3.72-16.38) for those with more than 210 cows, relative to the risk in herds with less than 30 cows, the base category. While these results demonstrate a significant reduction in the prevalence of properties with bovine brucellosis, the disease is still present in Minas Gerais, with properties with higher numbers of cows at higher risk for infection. ResumoUm estudo transversal foi realizado no estado de Minas Gerais, Brasil, em 2011, para estimar a soroprevalência da brucelose bovina (Brucella abortus) em propriedades e bovinos e identificar possíveis fatores de risco para a infecção nos rebanhos com fêmeas em idade reprodutiva. O estado foi regionalizado em sete estratos: 1. Regiões Noroeste, Norte e Nordeste; 2. Região Leste; 3. Região Central; 4. Região da Zona da Mata; 5. Regiões Sul e Sudoeste; 6. Região do Alto Paranaíba; 7. Região do Triângulo Mineiro, e a amostragem foi aleatória em dois estágios: de propriedades e, posteriormente, de bovinos em cada uma das mesmas. Foram coletadas amostras de sangue de 18.990 fêmeas em idade reprodutiva em 2.185 propriedades. Os testes sorológicos utilizados na detecção de anticorpos contra B. abortus foram o teste do antígeno acidificado tamponado e, como confirmatório, o teste de redução do 2-Mercaptoetanol, rotina preconizada pelo Programa Nacional de Controle e Erradicação da Brucelose e Tuberculose Animal (PNCEBT). O resultado da soroprevalência da brucelose bovina em propriedades e animais foi de 3.59% (IC 95%: 2,76-4,42%) e 0,81% (IC 95%: 0,05-1,10%), respectivamente. A análise de regressão logíst...

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Pathological, Immunohistochemical and Bacteriological Study of Tissues and Milk of Cows and Fetuses Experimentally Infected with Brucella abortus

Cited by 155 publications

References 22 publications

Economic losses due to bovine brucellosis in Brazil

Economic losses due to bovine brucellosis in Brazil

Detecção de Brucella abortus em linfonodos de búfalas (Bubalus bubalis) em diferentes fases da gestação

Seroprevalence and risk factors for bovine brucellosis in Minas Gerais State, Brazil

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