New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline

Abstract

SUMMARYBackground: In functional gastrointestinal (GI) disorders including functional dyspepsia (FD) and irritable bowel syndrome (IBS), there might be no small extent of contributions of psychosomatic factors. As a therapy for IBS patients, the effectiveness of antidepressants has been reported. Aim: In this study, we evaluated the efficacy of H 2 -receptor antagonist (famotidine) and 5-HT 4 receptor agonist (mosapride citrate). In addition, the effect of antidepressants was assessed as the second-step therapy. Methods: Patients complaining upper GI symptoms were diagnosed as FD excluding organic diseases. Randomized patients received 20 mg/day of famotidine or

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

“…Several studies showed that the anxiety, depression and somatoform disorders were the most common psychiatric problems found in patients with FD (Magni et al, 1987;Haug et al, 1994). Antidepressive drugs seem to be helpful in the treatment in some cases of FD patients (Mertz et al, 1998;Otaka et al, 2005). A meta-analysis published in 2005 demonstrated that anti-anxiety or anti-depressive drugs were effective in controlling symptoms in patients with FD (Hojo et al, 2005).…”

Dispepsia funcional e depressão como fator associado

“…Ampliando a polêmica sobre o tema, outro estudo também recente (22) , mostrou efetividade da amitriptilina sobre os sintomas de DF. Para além da discussão sobre efetividade do tratamento, é importante que se considerem os efeitos colaterais dos psicofármacos (cólicas, náusea e diarréia no caso dos SSRIs pelo seu efeito procinético, e constipação, no caso dos antidepressivos tricíclicos).…”

Effectiveness of amitriptyline for treating functional dyspepsia in adolescents

“…In that study, amitriptyline was also effective for treating functional dyspepsia. 21 In addition, another US study in 90 children aged 8 to 17 years who had functional gastrointestinal disorders, reported that amitriptyline and placebo both gave a good response to therapy, but with no significant difference between amitriptyline and placebo after 4 weeks of treatment. 1 A study in adult patients with irritable bowel syndrome (IBS) showed that anxiety levels correlated with placebo analgesic effects.…”