This multicenter prospective study showed favorable short-term outcomes for gastric ESD.

SUMMARYBackground: In functional gastrointestinal (GI) disorders including functional dyspepsia (FD) and irritable bowel syndrome (IBS), there might be no small extent of contributions of psychosomatic factors. As a therapy for IBS patients, the effectiveness of antidepressants has been reported. Aim: In this study, we evaluated the efficacy of H 2 -receptor antagonist (famotidine) and 5-HT 4 receptor agonist (mosapride citrate). In addition, the effect of antidepressants was assessed as the second-step therapy. Methods: Patients complaining upper GI symptoms were diagnosed as FD excluding organic diseases. Randomized patients received 20 mg/day of famotidine or

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