Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

Piriyapong, Kitiyawadee; Tangaroonsanti, Anupong; Mahachai, Varocha; Vilaichone, Ratha-Korn

doi:10.7314/apjcp.2014.15.24.10887

Cited by 13 publications

(6 citation statements)

References 48 publications

(51 reference statements)

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“…The difference could be due to the difference in the study population (target population; minor ethnic groups, but not the Kinh ethnic group; general population, but not the hospital population), methodology (some studies used only serological test or rapid urine test). However, the result remained in line with the data reported by other countries in the Southeast Asia area, such as Thailand (23.3%–45.9%) [ 14 , 15 ], Laos (36.2%) [ 16 ], Myanmar (48%) [ 17 ], and Cambodia (approximately 30%, our unpublished data). Thus, it could be hypothesized that the prevalence of H. pylori infection in Vietnam might be not as high as previously reported.…”

Section: Discussionsupporting

confidence: 91%

Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study

Binh

Tuan

Dung

et al. 2018

IJMS

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The Helicobacter pylori-induced burden of gastric cancer varies based on geographical regions and ethnic grouping. Vietnam is a multiethnic country with the highest incidence of gastric cancer in Southeast Asia, but previous studies focused only on the Kinh ethnic group. A population-based cross-sectional study was conducted using 494 volunteers (18–78 years old), from 13 ethnic groups in Daklak and Lao Cai provinces, Vietnam. H. pylori status was determined by multiple tests (rapid urease test, culture, histology, and serology). cagA and vacA genotypes were determined by PCR-based sequencing. The overall H. pylori infection rate was 38.1%. Multivariate analysis showed that variations in geographical region, age, and ethnicity were independent factors associated with the risk of H. pylori acquisition. Therefore, multicenter, multiethnic, population based study is essential to assess the H. pylori prevalence and its burden in the general population. Only the E De ethnicity carried strains with Western-type CagA (82%) and exhibited significantly lower gastric mucosal inflammation compared to other ethnic groups. However, the histological scores of Western-type CagA and East-Asian-type CagA within the E De group showed no significant differences. Thus, in addition to bacterial virulence factors, host factors are likely to be important determinants for gastric mucosal inflammation and contribute to the Asian enigma.

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Section: Discussionsupporting

confidence: 91%

Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study

Binh

Tuan

Dung

et al. 2018

IJMS

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“…The prevalence of H. pylori infection in Thailand has been recently estimated as 35%, 5,9 similar to Laos, a neighboring country that has an H. pylori infection rate of 36.2%. 10 Mountain people of Thailand generally have lower economic status with poor sanitation and water supplies compared with other regions of the country and thus would be expected to have a high prevalence of H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Extremely High Prevalence of Metronidazole-Resistant Helicobacter pylori Strains in Mountain People (Karen and Hmong) in Thailand

Vilaichone¹,

Ratanachu‐ek²,

Gamnarai³

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. This study aimed to survey the prevalence, patterns of antibiotic resistance, and clinical factors associated with antibiotic resistance in Helicobacter pylori among the Karen and Hmong mountain people of Thailand. We recruited dyspeptic patients in the Maesod district, Tak Province, Thailand. All subjects underwent upper gastrointestinal endoscopy, and three antral gastric biopsies were obtained for rapid urease tests and culture. An epsilometer was used to determine the minimum inhibitory concentrations of amoxicillin (AMX), clarithromycin (CLR), metronidazole (MNZ), levofloxacin (LVX), ciprofloxacin (CIP), and tetracycline (TET). A total of 291 subjects were enrolled; 149 (51.2%) were infected with H. pylori. Helicobacter pylori infection was present in 47.1% of Thai, 51.7% of Karen, and 58.7% of Hmong subjects. Antibiotic resistance was present in 75.8% including AMX (0.8%), TET (0%), CLR (5.6%), MNZ (71.8%), CIP (19.4%), LVX (19.4%), and multidrug resistance in 21.8%. Karen subjects had the highest prevalence of MNZ resistance (84.6%), and Hmong subjects had the highest prevalence of fluoroquinolone (27.3%) and multidrug (34.1%) resistance. MNZ plus fluoroquinolone (14.5%) was the most common multidrug resistance. There was no association between clinical factors and antibiotic resistance. MNZ resistance was prevalent, whereas fluoroquinolone-and multidrug-resistant H. pylori infections are important problems in mountain people of Thailand.

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“…Piriyapong et al found that patients with functional dyspepsia commonly have H. pylori infection, anxiety, and depression and that it is more prevalent in postprandial dyspepsia than epigastric pain dyspepsia [34]. They concluded that H. pylori eradication might be the key to success for the treatment of F.D patients and to prevent the development of gastric cancer [34]. Ünal et al enrolled 54 patients with functional dyspepsia and H. pylori infection without knowing their psychiatric illnesses [35].…”

Section: Reviewmentioning

confidence: 99%

The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

Quraan

Beriwal

Sangay

et al. 2019

Cureus

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The clinical practice of adding antidepressant drugs to the therapy for the eradication of Helicobacter pylori (H. pylori) in addition to the standard drug regimen is not yet well established. This study aims to establish if there is an association between H. pylori gastritis and depression and to further analyze the therapeutic effect of antidepressants on symptomatic relief in gastritis. A systematic review was done using articles collected within the last seven years without regional or language localization obtained using PubMed, PubMed Central® (PMC), Google Scholar, and the Cochrane controlled trials. The search terms included Helicobacter pylori, depression, functional dyspepsia, and antidepressants. We selected three randomized controlled trials (RCTs), eight cross-sectional studies, four prospective studies, one cohort study, and two review articles. Trials that were prescribed antidepressants for clinical improvement of dyspepsia in patients with H. pylori gastritis that showed no improvement after eradication therapy standard regimen were included. In conclusion, patients who showed no improvement in functional dyspepsia after H. pylori eradication were seen to improve on antidepressant therapy. Further investigation and studies to analyze this correlation are recommended.

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Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

Cited by 13 publications

References 48 publications

Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study

Molecular Epidemiology of Helicobacter pylori Infection in a Minor Ethnic Group of Vietnam: A Multiethnic, Population-Based Study

Extremely High Prevalence of Metronidazole-Resistant Helicobacter pylori Strains in Mountain People (Karen and Hmong) in Thailand

The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review

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