Nevoid hyperkeratosis of the nipple and areola: treatment with topical retinoic acid

Abstract

Nevoid hyperkeratosis of the nipple and areola is a rare dermatosis with unknown etiology, (Perez-Izquierdo JM, Vilata JJ, Sanchez JL, et al. Retinoic acid treatment of nipple hyperkeratosis. Arch Dermatol 1990;126:687-688). Only 40 cases have been reported until 1997 (Alpsoy E, Yilmaz E, Aykol A. Hyperkeratosis of the nipple: report of two cases. J Dermatol 1997;24:43-45). The disease has a benign course and may only be a cosmetic problem. Different modalities have been used in the treatment of NHNA. In our case treatment with topical retinoic acid induced an acceptable response.

Nevoid hyperkeratosis of the nipple mimicking a pigmented basal cell carcinoma

“…There are no consensus guidelines about the treatment; topical agents such as keratolytics, steroid, retinoids, or calcipotriol and ablative modalities like cryotherapy, carbon dioxide laser, radiofrequency, or shave excision are all potential treatment options 6, 7, 8…”

Treatment of Nevoid Hyperkeratosis of the Nipple and Areola Using a Radiofrequency Surgical Unit

“…Apart from a few case reports, there are no detailed studies with regard to treatment options 1–10,12–14 . Among these, keratolytic medications are the most commonly used treatments 1–6 . In some cases, the insufficiency of these treatments has also been reported 2,5,7,14,15 .…”

“…Among these, keratolytic medications are the most commonly used treatments 1–6 . In some cases, the insufficiency of these treatments has also been reported 2,5,7,14,15 . Cryotherapy 8,9 and the CO 2 laser 10 are the other treatment modalities for NHNA reviewed in the literature.…”

“…Cryotherapy 8,9 and the CO 2 laser 10 are the other treatment modalities for NHNA reviewed in the literature. Although surgical excision of NHNA lesions has also been suggested as an alternative to medical therapy, 16 its efficacy has not been clarified 5 …”

“…HYPERKERATOSIS OF the nipple and areola is a very rare dermatosis characterized by slowly growing verrucous thickening and brown pigmentation of the nipple and areola. Topical keratolytics, 1–7 corticosteroids, 2 antipsoriatic agents, 1 cryotherapy, 8,9 and carbon dioxide laser 10 are the therapeutic options for the disorder. We present a case of nevoid hyperkeratosis of the nipple and areola (NHNA) that was treated with a radiofrequency surgical unit.…”