Nevoid hyperkeratosis of the nipple mimicking a pigmented basal cell carcinoma

Mazzella, Caterina; Costa, Cláudia; Fabbrocini, Gabriella; Marangi, Giovanni Francesco; Russo, Daniela; Merolla, Francesco; Scalvenzi, Massimiliano

doi:10.1016/j.jdcr.2016.09.007

Cited by 16 publications

(12 citation statements)

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“…Two primary MMs, two nevi, PDs, melanoses, two BCCs, two nevoid hyperkeratosis, three adenomas/erosive adenomatosis of the nipple one eczema and five vemurafenib‐induced hyperkeratosis have been described in case reports. Most descriptions only concern dermoscopy, and only eight cases have been evaluated with RCM . Moreover, a large multicentric study evaluated 131 NAC lesions at clinical, dermoscopic and RCM examination and compared the diagnostic accuracy of these three examinations .…”

Section: Resultsmentioning

confidence: 99%

Nipple and areola lesions: review of dermoscopy and reflectance confocal microscopy features

Cinotti

Galluccio

Tognetti

et al. 2019

Acad Dermatol Venereol

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The differential diagnosis of nipple and areola complex (NAC) lesions encompasses a large spectrum of conditions from benign tumours to inflammatory diseases that could be challenging to recognize on clinical ground. While melanoma (MM) of the NAC is exceedingly rare, benign lesions are more frequent but could be difficult to distinguish from MM.Besides MM, other malignant tumours can affect this area and in particular Paget's disease (PD). For clinically doubtful lesions, biopsy is required, with possible functional and aesthetic consequences in this sensitive area. Dermoscopy and reflectance confocal microscopy (RCM) are widely used techniques for the diagnosis of many skin lesions, but their use for NAC lesions is not well established. The objective of this study was to evaluate current literature on these imaging techniques for NAC lesions. We searched in Medline, PubMed and Cochrane database all studies up to November 2018 dealing with dermoscopy, RCM and this special site. We found that the most described malignant tumour was PD and that only three primary MMs of the NAC have been reported with these imaging techniques. Although there are few data on diagnostic accuracy of non-invasive imaging techniques for NAC lesions, it seems that dermoscopy and RCM can add relevant information to be integrated with clinical examination for the diagnosis of NAC lesions and in particular for the differential diagnosis of PD and eczema.

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Section: Resultsmentioning

confidence: 99%

Nipple and areola lesions: review of dermoscopy and reflectance confocal microscopy features

Cinotti

Galluccio

Tognetti

et al. 2019

Acad Dermatol Venereol

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“…NHNA is a rare and benign skin disease, which occurs predominantly in women of child-bearing age, especially during the second and the third decades of life. 4 It's first described in the medical literature by Tauber in 1923 as a benign dermatologic change in the nipple and areola, it may involve the nipple, the areola or both. 5 Approximately 50cases have been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Nevoid hyperkeratosis of the nipple mimicking a seborreic keratosis

Lamouaffaq

Baybay

et al. 2018

JDC

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“…Since dermoscopic findings have been reported only in an additional case (Mazzella et al, 2016), dermoscopy is not sufficient to differentiate NHNA from other conditions. There are no consensus guidelines about the treatment and response is unpredictable (Mazzella et al, 2016;Succaria et al, 2015;Tocco-Tussardi et al, 2016;Yaghoobi, & Feily, 2015).…”

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confidence: 97%

“…NHNA involves the nipple (17%), areola (25%), or both (58%) (Mazzella et al, 2016). Although NHNA affects both men and women, approximately 80% of cases occur in women and it is predominant between puberty and the third decade of life.…”

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confidence: 99%

“…However, an association with hormonal changes (menarche/pregnancy) has been observed. The clinical and/or dermoscopic differential diagnosis of NHNA includes a broad spectrum of diseases such as seborrheic keratosis, contact allergic dermatitis, dermatophytosis, acanthosis nigricans, epidermal nevus, nevus sebaceous, basal cell carcinoma, mycosis fungoides, Bowen's disease, Darier's disease, Paget's disease; confluent, and reticulate papillomatosis and underlying breast malignancy (Mazzella et al, 2016;Succaria, Rosenbaum, & Goldberg, 2015;Tocco-Tussardi, Mobargha, Bassetto, & Vindigni, 2016;Yaghoobi, & Feily, 2015). The diagnosis is based on the clinical-pathological correlation.…”

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confidence: 99%

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