Neutrale Ionophore mit Selektivität für Na ^⊕

Abstract

Neutral Ionophores with Selectivity for Na@New non-macrocyclic, electrically neutral ionophores 5 -9 are described. In membranes they induce selectivities of Na@ over KO by a factor of up to 20.Die Neutralliganden mit den Ether-Amid-Grundgerusten 1 -4 sind Ionophore hoher Kationenselektivitat -4). So induziert das zu 2 isologe N-Methylheptanamid in gewissen Mernbranen Selektivitaten von Na@ gegenuber K@ bis zu 2502). Mit makrocyclischen Systemen sind diese Werte nur knapp erreicht worden5). Durch eine Erweiterung des Ionophorgrundgerustes und den Einsatz des Konzeptes der Donor-Stereologie6) gelangten wir zu den neuen Liganden 5 -9. lYo 1 2 4 5Die rnit diesen Verbindungen an Polyvinylchlorid-Membranen und Weichmachern mit niedrigen Dielektrizitatskonstanten hervorgerufenen Alkali-und Erdalkali-Ionen-Selektivitaten sind in Tab. 1 zusammengestellt. Dort sind auch Werte fur die fruher beschriebenen Verbindungen In, Z4), 32) und die zu einem bekannten Ionophorl) isologe, im Rahmen der vorliegenden Arbeit dargestellte Verbindung 4 aufgenommen worden. Die KKM-Werte, die nach Lit.') an 0.1 M waRrigen Losungen der Metallchloride bei 20°C ermittelt werden, stehen fur die Bevorzugung des Ions M n o gegenuber Na@ durch die Membran. Durch die Erweiterung des Ligandgerustes (5 relativ Chem.

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors

“…As in the case of Li + ISEs, the first class of fully synthetic ionophores that was investigated were the noncyclic di- and triamides. − One of the most successful diamides was ETH 157 ( Na + -2 , log P TLC 4.6: 48 log −0.3; PL-4 as plasticizer). − Even though the discrimination of K + is poor, it can be used for measurements in extracellular fluids and has been applied in clinical analyzers. Whereas efforts to improve its selectivity by introducing substituents to the central aromatic ring were not successful, the use of a 1,8-naphthalenediol ( Na + -3 ) instead of the catechol unit improved log (SSM) to −0.7 and, upon further replacing the substituents on the nitrogens by cyclohexyl groups, to −1.3 ( Na + -4 , bis(1-butylpentyl)adipate) (SSM): K + , −1.5; H + , −0.6; Li + , −1.2; Ca 2+ , −2.9; BBPA; log P TLC 8.3). , A recent report described the use of Na + -5 for ISFETs with fluorosilicone membranes (log (FIM): K + , −1.8; Li + , −1.3; Ca 2+ , −3.0; NaTPB) .…”

“…Whereas efforts to improve its selectivity by introducing substituents to the central aromatic ring were not successful, 196 the use of a 1,8-naphthalenediol (Na + -3) instead of the catechol unit improved log K Na,K pot (SSM) to -0.7 and, upon further replacing the substituents on the nitrogens by cyclohexyl groups, to -1.3 (Na + -4, bis(1-butylpentyl)adipate). 197 A similar improvement in the discrimination of K + , accompanied by a smaller loss in that of Ca 2+ , was obtained by replacing the phenyl and benzyl groups of Na + -2 with cyclohexyl groups (Na + -5 (ETH 2120): log K Na,J pot (SSM): K + , -1.5; H + , -0.6; Li + , -1.2; Ca 2+ , -2.9; BBPA; log P TLC 8.3). 195,198 A recent report described the use of Na + -5 for ISFETs with fluorosilicone membranes (log K Na,J pot (FIM): K + , -1.8; Li + , -1.3; Ca 2+ , -3.0; NaTPB).…”

Barium-selective electrodes based on neutral carriers and their use in the titration of sulfate in combustion products

“…The solution was stirred for 30 min at room temperature. A solution of 12.08 g (40.0 mmol) of 2-bromo-lV,7V-dicyclohexylacetamide (8,10) in 50 mL of benzene was then added dropwise to the solution over a period of 30 min. After the mixture was refluxed for 6 h, the NaBr was filtered off and the solvent was evaporated in vacuo.…”