Neoangiogênese de retalhos cutâneos em ratos tratados com óleo de copaíba

Estevão, Lígia Reis de Moura; Medeiros, Juliana Pinto de; Scognamillo-Szabó, Márcia Valéria Rizzo; Baratella-Evêncio, Liriane; Guimarães, Ednaldo Carvalho; Câmara, Cláudio Augusto Gomes da; Evêncio-Neto, Joaquim

doi:10.1590/s0100-204x2009000400011

Cited by 15 publications

(14 citation statements)

References 12 publications

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“…Epithelialization was observed on the 14 th DPO also evident in the treated group. This suggests that topical use of copaiba oil possibly accelerated the cicatricial process while promoting a faster formation of granulation tissue, as has been described by ESTEVÃO et al (2009) and in wound healing with copaiba oil 10% in rat skin and MASSON (2011) in a skin ulcer model in rabbit ears.…”

Section: Lucas Et Alsupporting

confidence: 53%

“…The concentration of copaiba oil chosen in this study was based on the studies of ESTEVÃO et al (2009), MASSON (2011), and MASSON-MEYERS et al (2013) who presented satisfactory results in their studies using 10% copaiba oil-resin in the healing of rat skin. On the other hand, CAVALCANTI NETO et al (2005), using pure oilresin, observed delayed wound healing in rat skin, with a negative effect on the overall healing process of the wounds.…”

Section: Resultsmentioning

confidence: 99%

“…PAIVA et al (2002) reported the acceleration of wound contraction topically treated with this phytotherapic in rats. The efficiency of copaiba oil in the neoangiogenesis of skin flaps in rats was demonstrated by ESTEVÃO et al (2009). In a skin ulcer model in rabbit ears (MASSON, 2011) and wound healing in rats (MASSON-MEYERS et al, 2013) at a concentration of 10%, stimulation of fibroplasia, reepithelization and remodeling were noted.…”

Section: Introductionmentioning

confidence: 97%

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Copaiba oil in experimental wound healing in horses

et al. 2017

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The aim of this study was to evaluate the effects of 10% copaiba oil in experimentally induced wounds in horses. Four wounds were made in the lumbar and metacarpal regions of eight adult horses. In the treatment group, the wounds received 10% copaiba oil and in the control group 0.9% sodium chloride, in the daily dressing for 21 days. The wounds were evaluated three, 7, 14, and 21 days postoperatively. No significant differences were observed between the groups. The mean lumbar wound contraction rates were 80.54% and 69.64%, for the control and treated groups, respectively. For the wounds in the metacarpal region, these averages were 44.15% and 52.48%, respectively. Under the experimental conditions of the present study, it is concluded that 10% copaiba oil has beneficial in wound healing in the equine species and suggest that copaiba oil can be used as a therapeutic possibility in equine wound therapy.

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Section: Lucas Et Alsupporting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Copaiba oil in experimental wound healing in horses

et al. 2017

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“…Lucena et al 25 concluded that the use of hydroalcoholic extract of aroeira was favorable to heal rats that were submitted to cystotomy. Copaiba oil was effective in healing of random skin flaps in rats 26 .…”

Section: Morphological Analysis Demonstrated a High Concentration Of mentioning

confidence: 94%

Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats

et al. 2013

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PURPOSE:To evaluate the effects of aroeira (Schinus terebinthifolius) ointment on skin wound healing in rats. METHODS:Adult male rats (n=20) were divided into four groups of five animals each, as follows: G4, G7, G14 and G21, which corresponds to 4 th , 7 th , 14 th and 21 th days postoperatively. Each animal were made two incisions on the skin, including the subcutaneous tissue, in the right and left sides of thoracic region, separated by a distance of two inches. The right lesion was treated with base ointment (vaseline, lanolin); the left one was treated with base ointment containing 5% of aroeira oil. At the end of each experimental period the lesions were evaluated for the contraction degree. Then held the collection of fragments that were fixed in 10% formalin and processed for paraffin embedding. In the histological sections (5μm) was evaluated the morphology and quantified the collagen and blood vessels.The data obtained were submitted to ANOVA test complemented by Tukey-Kramer test (p<0.05). RESULTS:The contraction of the lesions was higher in wounds treated with aroeira oil than in controls at 7 th and 14 th days (p<0.01), whereas in the 21 st day all lesions were already completely healed. The morphology showed granulation tissue more developed, with fibroblasts more bulky and collagen fibers more arranged in the experimental group at 4 th , 7 th and 14 th days. The morphometry showed a significant increase in the quantification of collagen fibers in the experimental group at 7 th and 14 th days (p<0.05). CONCLUSION:The aroeira oil accelerates the healing process of wounds as a macroscopic, morphological and morphometrical analysis.

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“…Several plant species have shown biological activities capable of inducing angiogenesis, such as: in the latex from Synadenium umbellatum, "Cola-nota"; in the essential oil from Schinus terebinthifolius Raddi, "Aroeira"; in the oil from Copaifera sp, "Copaíba"; in the latex from Hevea brasiliensis, "Seringueira"; in the crude extract of the roots from Memora nodosa, "Silva manso"; and in the ethanolic extract from Terminalia bellirica [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Atividade angiogênica do óleo de sucupira (Pterodon emarginatus)

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Silva

et al. 2015

Sci Med

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Aims: To assess the angiogenic activity of sucupira (Pterodon emarginatus) oil, popularly used as an antirheumatic, analgesic, antimicrobial, and anti-inflammatory agent. Methods: The chick (Gallus domesticus) embryo chorioallantoic membrane (CAM) assay was used as an experimental model, incubated in a temperature-and humidity-controlled automatic incubator during the first five days. A circular hole was made at the wider base of the eggshell on the fifth day. After 13 days of incubation, filter paper discs containing sucupira oil and control substances were inserted into the CAM. Subsequently, the CAMs were removed and submitted to analysis and quantification of the vascular network. The nonparametric KruskalWallis test, followed by Dunn's test, was used for the statistical analysis, and differences between the samples were set at a 5% level (p < 0.05). Results: Sucupira oil at a concentration of 1g/mL induced a significant increase in the percentage area of the CAM vascular network of the embryonated chicken eggs, when compared with the neutral control (water) and inhibitory control (dexamethasone) groups (p < 0.001). However, no significant difference in the induction of the CAM vascular network (p > 0.05) was demonstrated between the oil and the positive control (Biocure) groups. Conclusions:The sucupira (Pterodon emarginatus) bean oil induced the formation of new blood vessels under the experimental conditions of the present study. KEY WORDS: angiogenesis; membrane, chorioallantoic; Pterodon emarginatus RESUMOObjetivos: Avaliar a atividade angiogênica do óleo de sucupira (Pterodon emarginatus), popularmente utilizado como antirreumático, analgésico, antimicrobiano e anti-inflamatório. Métodos: Foi aplicado como modelo experimental o ensaio na membrana corioalantóidea (MCA) de ovo embrionado de galinha (Gallus domesticus). Os ovos foram incubados em estufa automática com temperatura e umidade controladas durante os primeiros cinco dias. No quinto dia foi realizada uma abertura circular na base maior da casca do ovo. No 13º dia de incubação, discos de papel de filtro contendo óleo de sucupira e as substâncias controle foram inseridos sobre vasos da MCA. Posteriormente, as MCAs foram removidas e passaram por análise e quantificação da rede vascular. Para análise estatística foi utilizado o teste não paramétrico de Kruskal-Wallis, seguido de Dunn, sendo os valores aceitáveis para diferenças significativas entre as amostras de p < 0.05. Resultados: O óleo da fava de sucupira na concentração de 1g/mL induziu um aumento significativo na área de porcentagem da rede vascular na MCA do ovo embrionado de galinha, quando comparados aos grupos controles neutro (água) e inibidor (dexametasona) (p < 0.001). Porém, não foi demonstrada diferença significativa entre o óleo e o controle positivo (Biocure) na indução da rede vascular na MCA (p > 0.05). Conclusões: O óleo da fava de sucupira (Pterodon emarginatus), nas condições deste experimento, foi responsável pela formação de novos vasos sanguíneos.

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Neoangiogênese de retalhos cutâneos em ratos tratados com óleo de copaíba

Cited by 15 publications

References 12 publications

Copaiba oil in experimental wound healing in horses

Copaiba oil in experimental wound healing in horses

Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats

Atividade angiogênica do óleo de sucupira (Pterodon emarginatus)

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