Copaiba oil in experimental wound healing in horses

Abstract

The aim of this study was to evaluate the effects of 10% copaiba oil in experimentally induced wounds in horses. Four wounds were made in the lumbar and metacarpal regions of eight adult horses. In the treatment group, the wounds received 10% copaiba oil and in the control group 0.9% sodium chloride, in the daily dressing for 21 days. The wounds were evaluated three, 7, 14, and 21 days postoperatively. No significant differences were observed between the groups. The mean lumbar wound contraction rates were 80.54% and 69.64%, for the control and treated groups, respectively. For the wounds in the metacarpal region, these averages were 44.15% and 52.48%, respectively. Under the experimental conditions of the present study, it is concluded that 10% copaiba oil has beneficial in wound healing in the equine species and suggest that copaiba oil can be used as a therapeutic possibility in equine wound therapy.

Experimental skin wound treatment with Copaifera langsdorffii Desf Kuntze (Leguminosae) extract and oil-resin in horses

“…At the same time, biopsies showed a large number of typical lymphocytic infiltrate cells, and abundant cellular debris, consistent with the description of Ribeiro et al (2013), where the development of perilesional edema was observed from 24 h to the fourth day of treatment. In a study performed by Lucas et al (2017) with 10% copaiba essential oil on wounds in the lumbar and metacarpal regions of horses, a non-exudative repair process was reported, which was consistent with our results after 3 d of treatment with oil-resin cream. In rats, there was significant activity in the inflammatory mechanism of Copaifera langsdorffii creams (Gushiken et al, 2017b).…”

“…As a physiological control of the healing, we used saline isotonic solution, which has been characterized as non-toxic and non-aggressive to scar tissue (Beam, 2006). In horses, an experimental study was performed using 10% copaiba oil to treat induced skin wounds and presented results that were indicative of its use for the treatment of wounds in this species (Lucas et al, 2017). However, the study addressed only the macroscopic reduction of the lesions and did not report the mechanisms and clinical parameters involved; thus, there is a need for further studies to elucidate the mechanisms of action of this treatment.…”

“…Due to its use in popular medicine since the 16 th century, studies have reported several biological activities related to the Copaifera langsdorffii oil-resin and leaves extract, as well as skin wound healing (Gushiken et al, 2017a;Lemos et al, 2015;Masson-Meyer et al, 2013), anti-microbial activity (Abrão et al, 2015), gastrointestinal diseases treatments (Gomes et al, 2007;Lemos et al, 2015;Paiva et al, 2002), antiedematogenic (Furtado et al, 2015), antinociceptive (Gomes et al, 2007) and urolithiasis treatment (Brancalion et al, 2012;Oliveira et al, 2013). However, there are few studies reporting copaiba effects in horse skin wound healing (Lucas et al, 2017).…”

Perfil Dos Casos De Coqueluche No Estado De Goiás

“…Nenhum animal manifestou ocorrência de dor em nenhum momento, e, a aplicação de fenilbutazona nos três primeiros dias foi realizada baseando-se em atendimento da rotina em animais que sofrem traumatismos na pele. Os anti-inflamatórios não esteroidais são frequentemente usados em estudo de processo cicatricial em várias espécies (DUARTE et al, 2012;LUCAS et al, 2017).…”

“…Salienta-se que no dia 17, durante o procedimento do curativo, todas as feridas de todos os animais encontravam-se totalmente epitelizadas. O processo cicatricial dos ovinos ocorre num tempo mais curto (média de 17 dias), quando comparado com a cicatrização de feridas na espécie equina, com média de 35 dias (LUCAS et al, 2017)…”