Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity

Abstract

The PRHD@MnFe2O4 binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe2O4 was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe2O4 hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field.

Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4/Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications

“…A recent study by Zachanowicz et al found that the number of viable bacteria was significantly reduced after exposure to binary polyrhodanine manganese ferrite nanohybrids. This effect was directly related to the amount of nanohybrid polymer content, and the higher the amount, the more antimicrobial effects [ 38 ]. The antibacterial activity of PR/Fe/Go synthesized in kombucha supernatant media showed more potent than their non-bioinorganic synthesis.…”

Impact of Polyrhodanine Manganese Ferrite Binary Nanohybrids (PRHD@MnFe2O4) on Osteoblasts and Osteoclasts Activities—A Key Factor in Osteoporosis Treatment

“…Since the physicochemical properties of the hybrid materials were already a subject of our recent studies, the reader is strongly encouraged to familiarize themselves with the results presented earlier, where detailed characteristics can be found [ 8 ]. Here we would like to underline that both stocks of nanoparticles and composites are well defined since they are from the same synthetic batch in both articles.…”

“…Protocols of the MnFe 2 O 4 nanoparticles and PRHD@MnFe 2 O 4 composites synthesis were described by us in detail elsewhere [ 8 , 10 ]. Metal acetylacetonate complexes were weighted under a protective atmosphere of N 2 (acrylic glovebox P10R250T2, GS Glove Box Systemtechnik GmbH, Malsch, Germany).…”

“…Recently, polyrhodanine manganese ferrite binary nanohybrids (PRHD@MnFe 2 O 4 ) have been identified as an attractive source of superparamagnetic iron nanoparticles for potential biomedical application [ 8 ]. Due to their unique properties, superparamagnetic iron oxide nanoparticles (MNPs) have been proposed as a good candidate not only for bioimaging field of medicine, but also as an active agent that could promotes adipose stem progenitor cells’ (ASCs) proliferative activity [ 9 ].…”

Co0.5Mn0.5Fe2O4@PMMA Nanoparticles Promotes Preosteoblast Differentiation through Activation of OPN-BGLAP2-DMP1 Axis and Modulates Osteoclastogenesis under Magnetic Field Conditions

“…The measurements of the FTIR-ATR spectra were performed on a Nicolet iZ10 spectrometer (Thermo Fischer Scientific, Waltham, MA, USA) equipped in diamond ATR accessory covering the spectral range between 4000–500 cm −1 at room temperature. Magnetic characterization of the Co 1−x Mn x Fe 2 O 4 colloids was presented by us previously [ 16 ]; thus, the interested reader is advised to follow that article for details. The hybrid particle mean size and distribution were estimated by using free-image processing software ImageJ v.1.46 [ 17 ] through analysis of SEM images by taking into consideration of 100 hybrid particles (longest diameter was measured due to elongated shape of objects).…”