Local anesthesia obtained via iontophoresis as an aid to shave biopsy

Getting Drugs Across Biological Barriers

“…Iontophoretic transdermal delivery has been commercialized for the delivery of anesthetics and analgesics. [117, 120–121] …”

Lidocaine Iontophoresis for Local Anesthesia Before Shave Biopsy

“…Lidocaine iontophoresis provides anesthesia more rapidly than EMLA 10,11 and may be preferable for deeper procedures, as EMLA cream provides anesthesia to a depth of 5 mm in an hour, whereas lidocaine iontophoresis provides anesthesia of greater than 8 mm in 10 minutes. [17][18][19][20][21][22][23][24][25][26][27][28][29] In a comparative trial of EMLA and lidocaine iontophoresis before venous cannulation in pediatric subjects, lidocaine iontophoresis was significantly more effective in reducing the pain associated with the procedure. 17 EMLA may be considered for procedures that cover a larger surface area or multiple simultaneous procedures as the maximum area anesthetized by this iontophoretic system is only 13.4 cm 2 .…”

“…[15][16][17][18][19] Previous studies of iontophoresis for dermatologic procedures have been limited to a small number of patients and performed in uncontrolled settings. [20][21][22][23][24][25] To better assess its efficacy and safety, we performed a randomized, double-blinded comparison of lidocaine iontophoresis to placebo for topical anesthesia before shave biopsy.…”

Transdermal delivery by iontophoresis

“…Applications include local delivery of anaesthetics (e.g. lidocaine)25, steroids and retinoids to treat acne scarring26, for the relief of palmar and plantar hyperhidrosis27, and the administration of pilocarpine in the diagnosis of cystic fibrosis28–30. Other applications of transdermal iontophoresis include the administration of antiinflammatory drugs e.g.…”