Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, glycosuria, and sometimes ketonemia. The present study was carried out to assess prescribing practice and general trend of diabetes among patients at the Bombay Hospital, Indore. Prescriptions and complete records of diabetic patients were monitored and data was filed as per WHO prescription proforma. The study revealed that prescription of metformin (27%) and glimepiride (22.60%) were found to be maximum among various available antidiabetic drugs. Category wise the maximum prescribed drugs are glimepride (22.60%, sulfonylurea category), metformin (27%, biguanide category) and pioglitazones (13.90%, glitazone category). Insulin prescription was found to be very less (4.5%). Combination of metformin and glimepiride (20.86%) was prescribed most commonly. Most common disease associated with diabetes mellitus was found to be hypertension (35%). Highest prevalence of disease was found to be in the age group of 51 to 60 followed by age group of 41 to 50. Men patients (66.36%) were found to be predominated over women patients (33.64%).
Recently there has been an increased interest in using iontophoretic technique for the transdermal delivery of medications, both ionic and nonionic. This article is an overview of the history of iontophoresis and factors affecting iontophoretic drug transfer for the systemic effects and laws for development of Transdermal delivery system are discussed.
Natural sources have been important for the development of new active molecules for many years. Various small molecules with unique chemical skeleton and potent bioactivities were discovered through various sources like plants, marine products, and microorganisms, etc., which are considered as very important part of the nature. A number of potent antifungals have been originated from various natural sources. This account describes structure and activities of selected agents isolated from various natural sources.
The discovery of clinically relevant inhibitors of HIV-integrase for antiviral therapy has proven to be a challenging task. Ketoacid-derived inhibitors selectively inhibit the strand transfer reaction of HIV-integrase. To elucidate the structural properties required for HIV-integrase inhibitory activity, we present here the results of two-and three-dimensional (2D and 3D) QSAR studies of a series of 24 benzyl amide derivatives. The 2D-QSAR studies were performed using three methods: the multiple linear regression method (MLR), giving r 2 = 0.9340 and q 2 = 0.8471; the partial least squares method, with r 2 = 0.9291 and q 2 = 0.7896; and principle component analysis, giving r 2 = 0.6496 and q 2 = 0.3893. The 3D-QSAR studies were performed using the stepwise variable selection k-nearestneighbor molecular field analysis approach; a leave-one-out cross-validated correlation coefficient (q 2 ) of 0.4577 and a non-cross-validated correlation coefficient (r 2 ) of 0.5836 were obtained. Contour maps using this approach showed that steric effects dominantly determine binding affinities. The information rendered by 2D and 3D QSAR models may lead to a better understanding of structural requirements of HIV-integrase inhibitors and can help in the design of novel potent molecules.
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