Recently there has been an increased interest in using iontophoretic technique for the transdermal delivery of medications, both ionic and nonionic. This article is an overview of the history of iontophoresis and factors affecting iontophoretic drug transfer for the systemic effects and laws for development of Transdermal delivery system are discussed.
INTRODUCTION Rifapentine is a semisynthetic rifamycin derivative from the piperazinyl hydrazone class with a microbiologic profile similar to that of rifampin. 1 Its structure differs from that of rifampin by the presence of a cyclopentyl ring instead of a methyl group at the piperazinyl moiety. 2 The chemical formula of rifapentine is rifamycin, 3-[[(4cyclopentyl-1-piperazinyl)imino] methyl]. Its molecular formula is C 47 H 64 N 4O and its molecular weight is approximately 877 Da. 3 MATERIAL AND METHODS Rifapentine was obtained from Lupin Pharmaceuticals, Aurangabaad, as a gift sample. PVP-K30, HPMC and methanol were purchased from S.D.fine chemicals limited, Mumbai. All the carriers used were of analytical grade. Methods 8-10 The Preparation of drug-PVP-K30 and drug-HPMC solid dispersions were prepared by kneeding and solvent evaporation Techniques which are described below: (Table 1
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