An Approach to Enhance the Solubility of Rifapentine by Solid Dispersion Technique Using Hydrophilic Carriers

Abstract

INTRODUCTION Rifapentine is a semisynthetic rifamycin derivative from the piperazinyl hydrazone class with a microbiologic profile similar to that of rifampin. 1 Its structure differs from that of rifampin by the presence of a cyclopentyl ring instead of a methyl group at the piperazinyl moiety. 2 The chemical formula of rifapentine is rifamycin, 3-[[(4cyclopentyl-1-piperazinyl)imino] methyl]. Its molecular formula is C 47 H 64 N 4O and its molecular weight is approximately 877 Da. 3 MATERIAL AND METHODS Rifapentine was obtained from Lupin Pharmaceuticals, Aurangabaad, as a gift sample. PVP-K30, HPMC and methanol were purchased from S.D.fine chemicals limited, Mumbai. All the carriers used were of analytical grade. Methods 8-10 The Preparation of drug-PVP-K30 and drug-HPMC solid dispersions were prepared by kneeding and solvent evaporation Techniques which are described below: (Table 1