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Hakanen, M; Luotola, Kari; Salmi, Jorma; Laippala, Pékka; Kaukinen, Katri; Collin, Pekka

doi:10.1023/a:1012754824553

Cited by 64 publications

(13 citation statements)

References 22 publications

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“…So the rate of prevalence in this study was lower than other studies [8]. Most of the patients with CD were suffering from HT, but there was no significant statistical relation between CD and HT; however, in Hadithi et al study, there is relation between HT and CD [5], summarized prevalence of CD in hypothyroid patients in some studies (Table 3) [12–18].…”

Section: Discussionmentioning

confidence: 51%

Frequency of Celiac Disease in Patients with Hypothyroidism

Mehrdad

Mansour-Ghanaei

Mohammadi

et al. 2012

Journal of Thyroid Research

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Background. Celiac disease (CD) is closely associated with other autoimmune endocrine disorders, particularly autoimmune thyroid disease. The aim of this study was to find the frequency of celiac disease in patients with hypothyroidism in Guilan province, north of Iran. Methods. A total of 454 consecutive patients with hypothyroidism underwent celiac serological tests antiGliadin antibodies (AGA), antitissue transglutaminase antibodies (IgA-tTG) and antiendomysial antibodies (EMA-IgA). Small intestinal biopsy was performed when any of celiac serological tests was positive. Results. Eleven (2.4%) patients were positive for celiac serology, and two patients with documented villous atrophy were diagnosed with classic CD (0.4%; 95%). Two patients with classic CD had Hashimoto's thyroiditis (HT) (0.6%; 95%). Six (54.5%) of 11 were suffering from overt hypothyroidism and 45.5% from subclinical hypothyroidism. Six (54.5%) had HT, and 45.5% had nonautoimmune hypothyroidism. Conclusions. In this study, prevalence of CD was lower than other studies. Most of the patients with CD were suffering from HT, but there was no significant statistical relation between CD and HT.

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Section: Discussionmentioning

confidence: 51%

Frequency of Celiac Disease in Patients with Hypothyroidism

Mehrdad

Mansour-Ghanaei

Mohammadi

et al. 2012

Journal of Thyroid Research

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“…In a similar study of 79 patients with celiac disease and 184 healthy controls, which was carried out by Hakanen et al, the respective frequencies of positivity for anti-TPO antibody were 11.4 and 5.1%, respectively 12. In the same study, the frequency of anti-TG antibody was found to be 8.8% in the patients with celiac disease and 5.1% in the healthy controls; a significant difference was not reached between the groups 12. For patients with celiac disease and controls, the respective antibody positivity frequencies were as follows: anti-TPO, 9 (11.4%) patients with celiac disease and 9 (5.1%) controls; anti-TG, 7 (8.8%) patients with celiac disease and 9 (5.1%) controls.…”

Section: Discussionmentioning

confidence: 76%

“…On the other hand, Ansaldi et al found that, in 343 patients with celiac disease and 230 controls, the frequency of ATD was 26.2% in the former and 10% in the latter; this difference was significant (p<0.001) 14. In a similar study of 79 patients with celiac disease and 184 healthy controls, which was carried out by Hakanen et al, the respective frequencies of positivity for anti-TPO antibody were 11.4 and 5.1%, respectively 12. In the same study, the frequency of anti-TG antibody was found to be 8.8% in the patients with celiac disease and 5.1% in the healthy controls; a significant difference was not reached between the groups 12.…”

Section: Discussionmentioning

confidence: 89%

“…In genetically sensitive individuals, autoimmunity triggered by gluten may also cause the development of ATD. Although a specific influence of an HLA group has not been shown in ATD, it is known that, among the patients with celiac disease, the frequency of ATD is much greater in those with an HLA DQ2 haplotype 12. Collin et al determined the frequency of ATD to be 3.5% in patients with celiac disease and 2.7% in a control group; this difference was not significant 13.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, the differences were not statistically significant. The study of Collin et al was retrospective and the other two studies were case–control studies 12–14…”

Section: Discussionmentioning

confidence: 99%

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Autoantibody Frequency in Celiac Disease

Çağlar

Uğurlu

Özenoğlu

et al. 2009

Clinics

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AIM:In our study, we investigated the levels of glutamic acid decarboxylase antibody (anti-GAD), islet cell antibody (ICA), thyroperoxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), antinuclear antibodies (FANA), antibodies to double-stranded DNA (anti-ds DNA), antibody to Sjögren syndrome A antigen (anti-SSA), antibody to Sjögren syndrome B antigen (anti-SSB), Smith antibody (anti-Sm), smooth muscle antibodies (ASMA), and antimitochondrial antibody liver-kidney microsome (AMA-LKM) in patients with celiac disease as compared to healthy controls and autoimmune hypothyroid patients.MATERIALS AND METHODS:A total of 31 patients with celiac disease, 34 patients with autoimmune hypothyroidism and 29 healthy subjects were included in this study. Anti-SSA, anti-SSB, anti-Sm, anti-ds DNA, anti-GAD, anti-TPO and anti-TG were studied by Enzyme-Linked Immunosorbent Assay (ELISA), and AMA-LKM, ASMA, ANA and ICA were studied by immunofluorescence. Clinical data and the results of free thyroxine-thyroid stimulating hormone (FT4-TSH) were collected from the patients’ files by retrospective analysis. SPSS ver 13.0 was used for data analysis, and the χ2 method was used for comparisons within groups.RESULTS:The frequency of anti-SSA, anti-SSB, anti-GAD, anti-Sm, anti-ds DNA, AMA-LKM, ASMA, ANA and ICA were not significantly different between the groups. Levels of anti-TPO and anti-TG antibodies were found to be significantly higher (<0.001) in autoimmune hypothyroid patients when compared with other groups.CONCLUSION:In previous studies, an increased frequency of autoimmune diseases of other systems has been reported in patients with celiac disease. We found that the frequency of autoimmune antibodies specific for other autoimmune diseases was not higher in celiac disease.

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Antitissue Transglutaminase and Antithyroid Autoantibodies in Children with Down Syndrome and Celiac Disease

Hansson,

Dahlbom,

Rogberg

et al. 2005

J. pediatr. gastroenterol. nutr.

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Objectives:We measured circulating autoantibodies and evaluated the potential of circulating antitissue transglutaminase (tTG) antibodies to determine the presence of celiac disease (CD) in children with Down syndrome.Methods:An ELISA based on recombinant human tTG was used to measure the levels of immunoglobulin A and immunoglobulin G antibodies in serum samples from 72 children with Down syndrome, 52 children with biopsy‐verified CD, 21 disease controls with a normal small intestinal mucosa and 23 healthy controls. Of the 72 Down syndrome children, 11 under‐went a small intestinal biopsy.Results:Four of 72 children with Down syndrome were diagnosed as having CD and three of them had serum levels of immunoglobulin A tTG antibodies greater than 6 U/mL (668, 147 and 7 U/mL). One Down syndrome child with biopsyproven CD had normal levels of immunoglobulin A tTG. Two Down syndrome children had increased levels of immunoglobulin A tTG (13 and 7 U/mL) but none of these children had an intestinal biopsy performed. Of the 52 CD subjects (median 664 U/mL) one was negative for immunoglobulin A tTG (5 U/mL) and all healthy controls (median 1.2 U/mL) and disease controls (median 0.9 U/mL) had immunoglobulin A tTG antibody levels less than 6 U/mL. Two of four Down syndrome children with CD and 36 of 52 celiac children had increased serum levels of immunoglobulin G tTG antibodies. There was no correlation between the serum levels of tTG and antithyroid autoantibodies.Conclusions:Although the diagnosis of CD depends on histologic evaluation of intestinal biopsies, detection of anti‐tTG antibodies provides a useful complementary diagnostic method for CD in children with Down syndrome.

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Cited by 64 publications

References 22 publications

Frequency of Celiac Disease in Patients with Hypothyroidism

Frequency of Celiac Disease in Patients with Hypothyroidism

Autoantibody Frequency in Celiac Disease

Antitissue Transglutaminase and Antithyroid Autoantibodies in Children with Down Syndrome and Celiac Disease

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