Autoantibody Frequency in Celiac Disease

Çağlar, Erkan; Uğurlu, Serdal; Özenoğlu, Aliye; Can, Günay; Kadıoğlu, Pınar; Dobrucalı, Ahmet

doi:10.1590/s1807-59322009001200009

Cited by 22 publications

(21 citation statements)

References 25 publications

(34 reference statements)

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“…Utiyama et al detected ANA positivity to be significantly high in CD with a frequency of 8.9% (23). In the study by Caglar et al, ANA frequency in the patients with CD was 12.9%, but there was no significant difference between the patients and healthy controls (13.8%) (24). In our study, the ANA test was positive in 12 (14.6%) patients.…”

Section: Discussioncontrasting

confidence: 56%

Primary Sjögren’s syndrome in patients with celiac disease

Erbasan¹,

Çoban²,

Karasu³

et al. 2017

Turk J Med Sci

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Background/aim: Many autoimmune diseases occur concomitantly with celiac disease (CD). We aimed to determine the frequency of Sjögren's syndrome (SS) in CD patients based on SS-specific serology verified by minor labial salivary biopsy.Materials and methods: Eight-two patients with CD were included in the study. After examination for objective evidence of sicca complex, all patients were tested for serological presence of rheumatoid factor (RF) and antinuclear antibodies (ANAs) and for ANA profile. Minor labial salivary biopsy was performed for patients with positive serology and/or clinical signs of SS.Results: Of the patients included, 24 (29.3%) had dry eye symptoms while 20 (24.4%) had dry mouth symptoms. Dry eye was detected by Schirmer test in 10 patients (12.2%) and by ocular staining score in only 2 patients (2.4%). All samples were negative for RF while 12 (14.6%) samples were positive for ANAs. Of 82 patients with CD, the diagnosis of SS was established in only one patient (1.2%), while one patient (1.2%) was diagnosed with morphea and 4 patients (4.9%) were classified as having undifferentiated connective tissue disease. Conclusion:The prevalence of SS in CD is low, so there is no need for serologic screening of all patients with CD for SS.

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Section: Discussioncontrasting

confidence: 56%

Primary Sjögren’s syndrome in patients with celiac disease

Erbasan¹,

Çoban²,

Karasu³

et al. 2017

Turk J Med Sci

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“…da Rosa Utiyama et al [50] conducted a study on 56 patients with CD, their 118 first-degree relatives and 101 healthy controls, and determined that ANA has a significantly increased frequency in the CD group compared with healthy controls. However, Caglar et al [51] did not determine a difference in ANA frequency between CD patients and control cases. Floreani et al [52] carried out a study on 361 patients with PBC and determined that ANA positivity was not associated with extrahepatic autoimmune conditions.…”

Section: Discussionmentioning

confidence: 98%

Risk Factors for Polyautoimmunity among Patients with Celiac Disease: A Cross-Sectional Survey

et al. 2015

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Aim: To define the prevalence of polyautoimmunity (PAI) among celiac disease (CD) patients and to compare clinical and laboratory features of CD patients with or without PAI in order to determine the risk factors for PAI in CD. Material and Method: Patients diagnosed with CD in our clinic between 2007 and 2014 with at least 1 year of follow-up were retrospectively evaluated. Totally 145 patients were included in the study. Information on patient demographics and laboratory data were obtained from patient records. The study participants were divided into 2 groups. Group 1 was the CD-alone group consisting of patients without any other autoimmune diseases (AIDs), while group 2 was the PAI group consisting of patients with accompanying one or more AIDs. Results: The mean age of 145 CD patients (106 female and 39 male) included in the study was 37.2 ± 12.3 years. Of the 145 patients included, 48 (33.1%) were in the PAI group. When two groups were compared with each other in terms of the demographic features and laboratory data, the following were identified as risk factors for PAI: female gender, family history for AIDs, antigliadin IgG positivity, vitamin D deficiency, antinuclear antibody positivity ≥1/80 titer and having any musculoskeletal disease. Conclusion: To the best of our knowledge, this is one of the largest studies in the literature on CD patients for the PAI prevalence and related risk factors. Identification of the risk factors in early stages is important to explore PAI among CD patients. Larger, prospective studies are warranted about the risk factors and autoimmune characteristics of CD.

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“…15 One study by Lerner et al 38 observed that in a group of patients with CD, 23% had anti-dsDNA and 14% had anticardiolipin antibodies. However, a study by Caglar et al 39 found no significant differences in the frequency of a number of anticytoplasmic and antinuclear antibodies between patients with CD and healthy controls. Additional studies are necessary to clarify the significance, if any, of these serologic abnormalities.…”

Section: Discussionmentioning

confidence: 92%

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

et al. 2015

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BACKGROUND AND OBJECTIVES: Current clinical guidelines do not consider patients with rheumatic conditions to be at high risk for celiac disease (CD) despite numerous reported associations between the two in adults and children. The objective of this study was to evaluate the prevalence of CD among patients presenting for pediatric rheumatology evaluation.METHODS: A total of 2125 patients presenting for initial evaluation by the Division of Pediatric Rheumatology at the Hospital for Special Surgery between June 2006 and December 2013 were screened for CD as a part of the standard initial serologic evaluation. The charts of these patients were evaluated retrospectively at the end of this period.RESULTS: 36 patients (30 girls, 6 boys, mean age 9.4 6 4.3 years, range 2-16 years) received a diagnosis of CD after serologic testing and evaluation by pediatric gastroenterology. Eight additional patients with known diagnoses of CD presented during this time period. The total prevalence of CD over this 6.5-year period was 2.0%. The most common presenting complaints among patients diagnosed with CD were myalgias, arthralgias, and rash. Less frequently, patients reported gastrointestinal complaints including abdominal pain, nausea, and diarrhea. All patients reported improvement or complete resolution of their musculoskeletal symptoms after initiation of a gluten-free diet.CONCLUSIONS: This study identified 36 new cases of CD among children presenting for rheumatology evaluation, for an overall prevalence rate of 2.0%. The majority of patients who ultimately received a diagnosis of CD presented with extraintestinal manifestations. These results underscore the importance of screening children presenting for rheumatology evaluation for CD. WHAT'S KNOWN ON THIS SUBJECT:Associations have been reported between celiac disease (CD) and numerous autoimmune conditions in adults and children. However, current screening guidelines do not consider patients with rheumatic diseases to be at high risk for CD. WHAT THIS STUDY ADDS:The prevalence of CD in children presenting for rheumatology evaluation was found to be 2% by routine serologic screening. The majority of screening-detected CD cases had no CD-associated symptoms. Gluten restriction was found to relieve some musculoskeletal complaints.

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Autoantibody Frequency in Celiac Disease

Cited by 22 publications

References 25 publications

Primary Sjögren’s syndrome in patients with celiac disease

Primary Sjögren’s syndrome in patients with celiac disease

Risk Factors for Polyautoimmunity among Patients with Celiac Disease: A Cross-Sectional Survey

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

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