Frequency of Celiac Disease in Patients with Hypothyroidism

Mehrdad, Mojtaba; Mansour-Ghanaei, Fariborz; Mohammadi, Fatemeh; Joukar, Farahnaz; Dodangeh, Salimeh; Mansour-Ghanaei, Roya

doi:10.1155/2012/201538

Cited by 22 publications

(25 citation statements)

References 31 publications

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“…44 Both celiac disease and autoimmune thyroiditis are more common among women. 21,34,41,42,44 This is consistent with the findings in the present study, in which 92.5% of the patients with autoimmune thyroiditis were female. However, the proportion of women found among the patients who were serologically posi- Ventura A, Ronsoni MF, Shiozawa MBC, Dantas-Corrêa EB, Canalli MHBS, Schiavon LL, Narciso-Schiavon JL ranging from 54.7 to 60.3 years (overall age range: 26-84).…”

Section: Discussionsupporting

confidence: 92%

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Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study

et al. 2014

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CONTEXT AND OBJECTIVE: Celiac disease is an autoimmune disorder with an average prevalence of 1% in Europe and the United States. Because of strong European ancestry in southern Brazil, this study aimed to evaluate the seroprevalence of celiac disease among autoimmune thyroiditis patients. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS:This cross-sectional prevalence study included autoimmune thyroiditis patients who were tested for anti-endomysial and anti-transglutaminase antibodies between August 2010 and July 2011. RESULTS: Fifty-three patients with autoimmune thyroiditis were included; 92.5% were women, with mean age of 49.0 ± 13.5 years. Five patients (9.3%) were serologically positive for celiac disease: three of them (5.6%) were reactive for anti-endomysial antibodies and two (3.7%) for anti-transglutaminase. None of them exhibited anemia and one presented diarrhea. Endoscopy was performed on two patients: one with normal histology and the other with lymphocytic infiltrate and villous atrophy. CONCLUSION: The prevalence of celiac disease among patients with autoimmune thyroid disease was 9.3%; one patient complained of diarrhea and none presented anemia. Among at-risk populations, like autoimmune thyroiditis patients, the presence of diarrhea or anemia should not be used as a criterion for indicating celiac disease investigation. This must be done for all autoimmune thyroiditis patients because of its high prevalence. RESUMO CONTEXTO E OBJETIVO:A doença celíaca é uma doença autoimune, com prevalência média de 1% na Europa e nos Estados Unidos. Em função da forte ascendência europeia no sul do Brasil, este estudo objetiva relatar a soroprevalência de doença celíaca em indivíduos com tireoidite autoimune. TIPO DE ESTUDO E LOCAL: Estudo transversal em um hospital público universitário. MÉTODOS: Este estudo transversal de prevalência incluiu pacientes com tireoidite autoimune que foram submetidos a testes de anticorpos antiendomísio e antitransglutaminase entre agosto de 2010 e julho de 2011. RESULTADOS: Foram incluídos 53 pacientes com tireoidite autoimune, 92,5% mulheres, com idade média de 49,0 ± 13,5 anos. Cinco (9,3%) pacientes apresentaram sorologia positiva para doença celíaca, sendo três (5,6%) com anticorpo antiendomísio positivo e dois (3,7%) com antitransglutaminase positivo. Nenhum paciente apresentou anemia e um apresentou diarreia. Apenas dois pacientes realizaram endoscopia: um com histologia normal e outro apresentou infiltrado linfocitário e atrofia vilositária. CONCLUSÕES: A prevalência de doença celíaca entre pacientes com doença autoimune da tireoide foi de 9,3%; um paciente queixou-se de diarreia e ninguém apresentou anemia. Em populações de risco, como é o caso de pacientes com tireoidite autoimune, a presença de diarreia ou anemia não devem ser utilizados como critério para indicar investigação de doença celíaca, que deve ser feita em todos os indivíduos com tireoidite autoimune devido a sua alta prevalência.

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Section: Discussionsupporting

confidence: 92%

“…21 Biochemical tests were expressed as absolute values. Those who presented negative results for both antibodies underwent quantitative assaying of total serum IgA, which ruled out a selective IgA deficiency.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study

et al. 2014

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“…(19), did not show a higher prevalence of CD in patients with hypothyroidism in an Iranian population, although their data disagree with those of various other authors (5,6,20).…”

Section: Discussioncontrasting

confidence: 55%

“…The association of thyroid autoimmune disease with other autoimmune disorders has been demonstrated previously (4)(5)(6). There is an increased prevalence of hypothyroidism and subclinical hypothyroidism in patients with celiac disease (CD), 19.2% and 21.2%, respectively, as described in Brazilian CD patients (7).…”

Section: Introductionmentioning

confidence: 99%

Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil

Teixeira

Nisihara

Utiyama

et al. 2014

Arq Bras Endocrinol Metab

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Objective: The objective of this study was to determine the prevalence of celiac disease (CD) in adults with autoimmune thyroid disease (ATD) from the endocrinology outpatient setting in a university hospital in Southern Brazil. Subjects and methods: From the years 2007 to 2011, 254 patients with ATD were enrolled consecutively, Grave's disease was diagnosed in 143 (56.3%) and Hashimoto's thyroiditis in 111 (43.7%) of them. All patients answered a questionnaire related to symptoms that could be associated with CD and serum samples to screen for IgA anti-endomysial (EmA-IgA) were collected. EmA-IgA-positive patients were offered upper gastrointestinal endoscopy and biopsy of duodenum. Results: A total of 254 patients were included; 222 (87.4%) female, mean age 45.4 ± 13.43 years (18 to 79 years). EmA-IgA was positive in seven patients (2.7%) and five done endoscopy with biopsy. Of these, three diagnosis of CD was confirmed (1.2%). All the three patients with CD had higher EmA-IgA titration, were female and had Hashimoto's thyroiditis. Like other patients with ATD, CD patients had nonspecific gastrointestinal symptoms, such as heartburn and gastric distention. In our study, one in each 85 patients confirmed the diagnosis of CD. Conclusion: We found a prevalence of 1.2% (1:85) of confirmed CD among Brazilian patients with ATD. Although some IgA-EmA positive patients had Graves' disease and one was male, all three patients with confirmed CD were female and had Hashimoto's thyroiditis.

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“…Common causes of elevated TSH in pregnancy include failure to increase thyroxine supplementation in hypothyroid women, poor medication adherence, interference with absorption due to calcium or iron containing foods/supplements, co‐existent coeliac disease, iodine deficiency/excess and women with nephrotic range proteinuria (due to urinary loss of thyroxine) …”

Section: Laboratory Investigationsmentioning

confidence: 99%

Review article: Investigations and the pregnant woman in the emergency department – part 1: Laboratory investigations

Morton

Teasdale

2018

Emerg Medicine Australasia

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Accurate assessment of the pregnant patient in the ED depends on knowledge of physiological changes in pregnancy, and how these changes may impact on pathology tests, appearance on point‐of‐care ultrasound and electrocardiography. In addition the emergency physician needs to be cognisant of disorders that are unique to or more common in pregnancy. Part 1 of this review addresses potential deviations in laboratory investigation reference intervals resulting from physiological alterations in pregnancy, and the important causes of abnormal laboratory results in pregnancy. Part 2 will address the role of point‐of‐care ultrasound in pregnancy, physiological changes that may affect interpretation of point‐of‐care ultrasound, physiological changes in electrocardiography, and the safety of radiological procedures in the pregnant patient.

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Frequency of Celiac Disease in Patients with Hypothyroidism

Cited by 22 publications

References 31 publications

Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study

Prevalence and clinical features of celiac disease in patients with autoimmune thyroiditis: cross-sectional study

Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil

Review article: Investigations and the pregnant woman in the emergency department – part 1: Laboratory investigations

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