Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr.

Wirasathien, Lalita; Pengsuparp, Thitima; Suttisri, Rutt; Ueda, Hirotaka; Moriyasu, Masataka; Kawanishi, Kazuko

doi:10.1016/j.phymed.2006.09.001

Cited by 54 publications

(33 citation statements)

References 19 publications

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“…The present results are in agreement with those of Ismail et al [5], Halima et al [28], Peyroux and Sternberg [29] and Wirasathian et al [30]. They reported that diabetes caused an oxidative stress include stimulation lipid peroxidation and protein glycation as well as inhibition of antioxidative enzymes with alteration in the structure and function of collagen and basement membranes as well as reduced tissue soluble protein.…”

Section: Discussionsupporting

confidence: 93%

“…They reported that diabetes caused an oxidative stress include stimulation lipid peroxidation and protein glycation as well as inhibition of antioxidative enzymes with alteration in the structure and function of collagen and basement membranes as well as reduced tissue soluble protein. Natural flavonoids such as those of Kafta, Somma, Araar and Doum methanolic extracts have been shown to reduce this oxidative stress in experiemental diabetes [31,32]. The lowering effect of plant flavonoids on diabetes may be due to the increase in insulin-receptor binding followed by increasing the signal sequences [33] or the antioxidant of these flavonoids.…”

Section: Discussionmentioning

confidence: 99%

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The antioxidative effects of some medicinal plants as hypoglycemic agents on chromosomal aberration and abnormal nucleic acids metabolism produced by diabetes stress in male adult albino rats

Salah¹,

Abdou²,

Azeem³

et al. 2011

JDM

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The objectives of the present study are to evaluate the chromosomal aberrations in somatic and germ cells of alloxanized diabetic rats treated with methanolic extracts of Cleome droserifolia (Sammo), Anastatica hierochuntica (Kafta), Juniperus phoencea (Araar) and Hyphaene thebaica (Doum) as well as their effects on blood glucose, liver and testes total soluble protein, DNA and RNA contents and also nucleases (RNAase and DNAase) activity. The material and Methods:The study was performed in six groups. The first group was the normal healthy control; the second group was rats injected with alloxan (diabetic control). Every one of the other four groups (diabetic rats) was ingested with each of the methanolic extracts of Kafta, Doum, Sammo and Araar (individually). The results: The results of chromosomal analysis showed that, diabetic rats had a highly significant increase of chromosomal aberrations compared to that of normal healthy control. Animals which treated with the four plants methanolic extracts showed significant improvements in the frequencies of chromosomal aberrations. In case of biochemical analysis, blood glucose level was significantly increased but immunoglobulins levels were decreased in diabetic albino rats. Diabetes increased serum total lipids, cholesterol, triglycerides and LDL but serum HDL was decreased. RNA and DNA as well as inhibited the nucleases (RNAase and DNAase) activity of both organs (liver and testes) tissue. The conclusions: It is concluded that diabetes is much harmful in the animal body, whilst the induction of flavonoids extract (by methanol) of Kafta, Somma, Araar and Doum reduced these harmful of diabetes.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The antioxidative effects of some medicinal plants as hypoglycemic agents on chromosomal aberration and abnormal nucleic acids metabolism produced by diabetes stress in male adult albino rats

Salah¹,

Abdou²,

Azeem³

et al. 2011

JDM

View full text Add to dashboard Cite

show abstract

“…(Annonaceae), have demonstrated AR inhibitory activity in porcine lens. They prevented sorbitol formation through inactivation of AR-substrate complex by formation of enzyme-substrate-inhibitor complex [72]. In an experiment among three phenolic compounds isolated from Phyllanthus niruni L. (Phyllanthaceae), including brevifolin carboxylic acid, ethyl brevifolin carboxylate, and ellagic acid, the latter one demonstrated the most potent AR inhibitory activity [73].…”

Section: Glucose Metabolism Controlmentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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“…Both astilbin and taxifolin (2, 3-dihydro quercetin), its aglycone, have been demonstrated to protect against oxidative damage [136]. Therefore, the antioxidant flavonoids such as engeletin and astilbin are potentially useful for therapeutic prevention of diabetic complications resulting from AGEs accumulation [137].…”

Section: `-O-[β -D-apiosyl (1→2)] -β -D-glucopyranosyl] -5-hydroxyl-mentioning

confidence: 99%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr.

Cited by 54 publications

References 19 publications

The antioxidative effects of some medicinal plants as hypoglycemic agents on chromosomal aberration and abnormal nucleic acids metabolism produced by diabetes stress in male adult albino rats

The antioxidative effects of some medicinal plants as hypoglycemic agents on chromosomal aberration and abnormal nucleic acids metabolism produced by diabetes stress in male adult albino rats

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

Plant-Derived Agents with Anti-Glycation Activity

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