A new natural C-benzylated chalcone, 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog, ellipeiopsol D, were also isolated. The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with IC50 values of 1.40, 5.31 and 13.92 microg/mL, respectively. This compound also showed antimalarial activity against Plasmodium falciparum with an IC50 value of 7.1 microg/mL as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL.

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Two dioxoaporphine alkaloids, N-methylouregidione (1) and ouregidione (2), and two oxoaporphine alkaloids, liriodenine (3) and oxostephanine (4), were isolated from the aerial part of Pseuduvaria setosa (King) J. Sinclair. All four alkaloids displayed antituberculosis activity against Mycobacterium tuberculosis, with 3 as the most active at minimum inhibitory concentration (MIC) of 12.5 mg=ml. Compound 3 was also the only alkaloid isolated from this plant that displayed antimalarial activity against Plasmodium falciparum with the 50% inhibitory concentration (IC 50) of 2.8 mg=ml. Compounds 3 and 4 were strongly cytotoxic to both epidermoid carcinoma (KB) and breast cancer (BC) cell lines, whereas 2 was moderately active against BC cells. Both 1 and 2 were active against small cell lung cancer (NCI-H187) cell line and were able to stimulate lymphocyte proliferation with stimulation indices (SI) of more than 1.

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