Gambaran Profil Lipid Pasien Perlemakan Hati Non-Alkoholik

Vanny, Syafitri; Arnelis, Arnelis; Efrida, Efrida

doi:10.25077/jka.v4i1.234

Cited by 6 publications

(7 citation statements)

References 7 publications

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“…An individual can experience dyslipidemia if there is an abnormality in one or more of the lipid profile components. 13 Based on examination of lipid profile levels, as many as 70.97% of patients who do lipid profile examination had low HDL levels, 75.81% of patients had above optimal LDL level, and 33.87% had triglyceride levels above normal.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang

Yetti

Prahastiwi

Susanti³

et al. 2020

InaJGHE

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Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is emerging as chronic liver disease, both in developed and developing countries. NAFLD affects up to 25% population worldwide. The incidence of NAFLD associated with various risk factors supporting the development of the fatty liver. This study aim is to know the characteristics of NAFLD patients.Method: Retrospective study was conducted from medical records to find the characteristics of patients diagnosed with NAFLD at Dr. M. Djamil General Hospital from January 2016 – December 2018.Results: Seventy-seven patients were diagnosed with NAFLD. The majority of NAFLD patients were male and female at 36-45 years old and female at 65 years old. Unemployed females were more prevalent compared to males. Dyslipidemia was the most component of a metabolic syndrome found in NAFLD patients. From laboratory findings, 55.56% of patients have increased aspartate aminotransferase (AST) levels, while 52.78% have increased alanine aminotransferase (ALT) levels. Ultrasonography used widely as a diagnostic device to detect NAFLD. Pharmacological therapy based on American Asociation for the Study of Liver Disease (AASLD) recommendation that used widely to treat patients with NAFLD was statin.Conclusion: The incidence of NAFLD was found to vary in different age ranges and sexes. Dyslipidemia occurred in most of NAFLD patients. AST and ALT levels increased in about half of the patients. Abdomen ultrasound as a diagnostic modality that was widely used.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang

Yetti

Prahastiwi

Susanti³

et al. 2020

InaJGHE

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“…Trigliserida selanjutnya akan didistribusi ke seluruh tubuh. Pada peningkatan trigliserida di hati akan terjadi pula peningkatan kadar trigliserida darah 3 . Selain itu, peningkatan trigliserida ini terjadi akibat peningkatan proses lipogenesis de-novo yaitu proses glukosa yang tidak terpakai menjadi sumber energi dikonversi menjadi asam lemak bebas selanjutnya disimpan dalam bentuk trigliserida di hati.…”

Section: Pendahuluanunclassified

“…Peningkatan kadar triglserida juga meningkatkan risiko terjadinya perlemakan hati non-alkoholik sebanyak 13 kali lipat daripada yang memiliki kadar trigliserida normal. 3 Hati merupakan sebuah organ besar yang mengandung sedikit jaringan ikat. Hati memiliki peran penting untuk metabolisme lipid, karena lipid diangkut di dalam darah sebagai lipoprotein, dan lipoprotein ini dibentuk di dalam hati.…”

Section: Pendahuluanunclassified

Pengaruh Ekstrak Biji Ketumbar (Coriandrum Sativum) Terhadap Kadar Trigliserida Dan Gambaran Histologi Hati Tikus (Rattus Novergicus) Yang Diinduksi Oleh Pakan Tinggi Lemak

Kodariah¹,

Wahid²

2020

jbmi

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AbstrakHiperlipidemia merupakan salah satu penyebab penyakit jantung koroner yang ditandai dengan adanya penumpukan lemak yang disebabkan oleh kadar trigliserida tinggi. Hiperlipidemia dapat mengakibatkan perlemakan hati (fatty-liver) sehingga hepatosit mengalami kerusakan dan peningkatan aktivitas enzim trans-aminase. Hati memiliki peran penting untuk metabolisme lipid karena lipid diangkut di dalam darah sebagai lipoprotein yang dibentuk di dalam hati. Tujuan penelitian ini adalah untuk mempelajari pengaruh ekstrak biji ketumbar terhadap kadar trigliserida serum darah dan gambaran histologi hati tikus putih yang diinduksi pakan tinggi lemak. Penelitian menggunakan metode eksperimen, sampel sebanyak 24 ekor tikus putih galur Wistar dikelompokkan kedalam 6 kelompok, yaitu: K1 (tikus diberi pakan normal dan diberi akuades), K2 (tikus hanya diberi pakan tinggi lemak), K3 (tikus diberi pakan tinggi lemak dan simvastatin dosis 0,18 mg/kg BB/hari), K4, K5, dan K6 (tikus diberi pakan diet tinggi lemak dan diberikan ekstrak biji ketumbar dengan dosis masing-masing 5,4 mg/kg BB/hari, 10,8 mg/kg BB/hari, dan 21,6 mg/kg BB/hari). Hasil penelitian menunjukkan adanya penurunan kadar trigliserida serum darah tikus sebelum dan setelah diberikan ekstrak biji ketumbar. Pada gambaran histologi K1, K3, K4, K5, dan K6 didapatkan gambaran histologi hati yang normal, sedangkan pada K2 ditemukan sel kariolisis (nekrosis). Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak biji ketumbar berpengaruh terhadap penurunan kadar trigliserida serum darah tikus dan adanya perubahan histologi hati pada kelompok tikus yang diberikan ekstrak biji ketumbar dengan kelompok yang tidak diterapi.Kata kunci: biji ketumbar, trigliserida, histologi, hati, hiperlipidemia.AbstractHyperlipidemia is one of the causes of coronary heart disease marked by the accumulation of fat caused by high triglyceride levels. Hyperlipidemia can cause fatty liver so that hepatocytes experience damage and increase the activity of the transaminase enzyme. The liver has an important role in lipid metabolism because lipids are transported in the blood as lipoproteins formed in the liver. The purpose of this study is to investigate the effect of coriander seed extract on blood serum triglyceride levels and the histological picture of white rat liver induced by high-fat feed. The study used an experimental method in which a sample of 24 white rats were grouped into 6 groups, K1 (rats were given normal feed and given aqua dest), K2 (rats were only given high-fat feed), K3 (rats were given high-fat feed and simvastatin dose 0. 18 mg/kg/day), while K4, K5, and K6 (rats were fed a diet high in fat and given coriander seed extract at a dose of 5.4 mg/kg/day, 10.8 mg/kg/day, and 21.6 mg/kg/day respectively). The results showed a decrease in rat serum triglyceride level before and after coriander seed extract was given. In the histological features of K1, K3, K4, K5, and K6, a normal histological picture of the liver was found, while karyolysis cells (necrosis) were observed in K2 group. Based on the results of the study, the coriander seed extract might affect the reduction in rat serum triglyceride level as well as the histological changes of liver in rats treated with coriander seed extract as compared to the untreated group.Keywords: coriander seed, triglyceride, histology, liver, hyperlipidemia

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“…This prevalence tends to increase over time due to the increasing prevalence of overweight and obesity. 11 In the research of Hasan et al with a large enough sample, the prevalence of non-alcoholic fatty liver was 30.6%, with risk factors for obesity, diabetes mellitus, and hypertriglyceridemia. The cases tend to increase along with changes in diet and lifestyle.…”

Section: Introductionmentioning

confidence: 96%

Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver

Desmawati

Nisa

Afriani

2022

mkb

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Indonesia is facing increased consumption of calorie-dense foods, such as fast food, among its society. Changes in diet and physical activities towards unhealthy ones can result in an imbalanced lifestyle, leading to various consequences, including hyperlipidemia. Pregnant women experience significant increases in plasma concentrations of lipids, lipoproteins, and apolipoproteins. Excessive cholesterol levels in pregnant women will result in the formation of fat in the liver. The purpose of this study was to determine the effect of a high-fat diet to pregnant Wistar rats (Rattus norvegicus) on the histopathological features of the liver. A true experimental with post test only control group design was applied in this study, which was conducted from August 2020 to November 2021. Fourteen (14) pregnant female rats were divided into two groups. The first group of rats was fed with a high-fat diet, while the second group, which was the control group, was given a standard diet. The high-fat diet used was 3 mL/rat/day beef brain. After the rats delivered their litters, the rats’ livers were retrieved, then examined histopathologically under a microscope. This research was conducted from No fatty liver was identified in the control group or the treatment group. Hence, a high-fat diet does not affect the liver histopathological features in pregnant Wistar rats.

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Gambaran Profil Lipid Pasien Perlemakan Hati Non-Alkoholik

Cited by 6 publications

References 7 publications

Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang

Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang

Pengaruh Ekstrak Biji Ketumbar (Coriandrum Sativum) Terhadap Kadar Trigliserida Dan Gambaran Histologi Hati Tikus (Rattus Novergicus) Yang Diinduksi Oleh Pakan Tinggi Lemak

Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver

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