Pengaruh Ekstrak Biji Ketumbar (Coriandrum Sativum) Terhadap Kadar Trigliserida Dan Gambaran Histologi Hati Tikus (Rattus Novergicus) Yang Diinduksi Oleh Pakan Tinggi Lemak

Kodariah, Liah; Wahid, Aziz Ansori

doi:10.22435/jbmi.v9i1.3899

Cited by 3 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sixteen duck egg yolks are mixed with 1,000 g of goat fat until soft and runny while adding hot water as needed. The two mixtures then mixed together until smooth (Kodariah & Wahid 2020).…”

Section: Parijoto Fruit Extract In Fatty Livermentioning

confidence: 99%

Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet

2023

View full text Add to dashboard Cite

This study aims to determine the effectiveness of parijoto fruit extract (Medinilla speciosa Blume) in improving the condition of fatty liver in male balb/c mice (Mus musculus L.) fed with a high-fat diet. Thirty male balb/c mice weighing 20 to 30 g were randomly divided into six groups, i.e: 1) Standard feed and Carboxymethyl Cellulose Sodium or CMC-Na 0.5% (K1); 2) High-fat diet and CMC-Na 0.5% (K2); 3) High-fat diet and simvastatin 0.026 mg/day (K3); 4) High-fat diet and parijoto fruit extract 5.6 mg/20 g BW (P1); 5) High-fat diet and parijoto fruit extract 8.4 mg/20 g BW (P2); 6) High-fat diet and parijoto fruit extract 11.2 mg/20 g BW (P3). Standard feed, high-fat diet, simvastatin, and parijoto fruit extract were administered for 56 days. On the 57th day, the total of 30 mice were terminated and the livers were then removed for H&E staining histopathological slides. Data on the degree of fatty liver on histopathological slides were collected and analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney test. The histopathological analysis showed Medinilla speciosa Blume extract at a dose of 5.6 mg/20 g BW in group P1 prevent the steatosis degree compared to high-fat feed mice in group K2 (p>0.05). Parijoto fruit extract could act as the potential treatment for fatty liver.

show abstract

“…Sixteen duck egg yolks are mixed with 1,000 g of goat fat until soft and runny while adding hot water as needed. The two mixtures then mixed together until smooth (Kodariah & Wahid 2020).…”

Section: Parijoto Fruit Extract In Fatty Livermentioning

confidence: 99%

Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet

2023

View full text Add to dashboard Cite

show abstract

“…Dalam penelitian Riyo et al (2019) dosis 360 mg/kg BB merupakan dosis yang paling efektif dari fraksi buah ketumbar terhadap gambaran histologi pankreas tikus putih yang diinduksi STZ. Hal ini sebanding dengan penelitian Kodariah & Wahid (2020) bahwasanya tikus yang diberikan terapi ekstrak biji ketumbar mengalami penurunan jumlah trigliserida darah dan terdapat perubahan pada gambaran histologis hati, daripada tikus yang tidak diterapi dengan ekstrak biji ketumbar.…”

Section: Antikolesterolunclassified

Literature Review: Potential of Coriander (Coriandrum sativum L.) as a Source of Natural Antioxidants

Ghina,

Yuniarti,

Atifah

2023

JBT

View full text Add to dashboard Cite

Indonesia is a country known for its richness in spices, one of the spices that is widely used by the people of Indonesia is coriander. Coriander is a spice that has many antioxidant compounds and biological activities that have the potential to be utilized as a source of natural antioxidants. The purpose of writing this article is to find out the potential of coriander plants as a source of natural antioxidants through literature review. The method used in writing this article is a Literature Review Article (LRA) with the Preferred Reposting Items for Systematic Review and Meta-Analysis (PRISMA) approach. Based on the results of the reviewed articles, 11 relevant articles were obtained stating that coriander has the potential as a source of natural antioxidants. coriander extract and its antioxidant compounds have biological activities such as antiinflammatory, antidiabetic, anticholesterol, and anticancer, so they can be used as herbs in the treatment of disease.

show abstract

Histopathological of Mice (Mus musculus) Liver Induced by Lead (Pb) Orally

Kodariah,

Efrida,

Aditya

et al. 2023

IJMLST

Self Cite

View full text Add to dashboard Cite

Lead (Pb) is a prominent heavy metal emitted by motor vehicle exhausts, factory and mining fumes. Its presence in the atmoshpere can endure for up to seven days, posing a considerable risk of contaminating surrounding food and beverages. Lead enters the body through inhalation and the skin. Lead can also enter the human body via the oral route and accumulate in the body. It causes health problems such as oxidative stress and damage human organs such as the kidneys and liver. This research aims to examine the effect of oral lead exposure on the liver histopathology of Swiss Webster strain mice (Mus musculus). Employing a non-probability sampling technique, 25 male mice were divided into 5 groups: negative control, K2, K3, K4 and K5. These mice were administered a daily oral dose of 0.5 mL and subsequently euthanized in CO2 chamber the following week for liver dissection. The findings reveal signs of hydropic degeneration characterized by cellular swelling, irregular shapes, and disrupted organelles in groups K2, K3, K4, and K5. In addition, the mean degree of liver damage was observed as 0 for the negative control, 1 for group K2, 1 for group K3, 2 for group K4, and 3 for group K5. In conclsuin, this study confirms that lead exposure can result in dentrimenal liver histopathology changes in mice.

show abstract

Pengaruh Ekstrak Biji Ketumbar (Coriandrum Sativum) Terhadap Kadar Trigliserida Dan Gambaran Histologi Hati Tikus (Rattus Novergicus) Yang Diinduksi Oleh Pakan Tinggi Lemak

Cited by 3 publications

References 2 publications

Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet

Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet

Literature Review: Potential of Coriander (Coriandrum sativum L.) as a Source of Natural Antioxidants

Histopathological of Mice (Mus musculus) Liver Induced by Lead (Pb) Orally

Contact Info

Product

Resources

About