Evaluation the effectiveness of combinative treatment of cold plasma jet, Indonesian honey, and micro-well dressing to accelerate wound healing

Nasruddin,; Putri, Indri Kartika; Kamal, Sodiq; Rahayu, Heni Setyowati Esti; Lutfiyati, Heni; Pribadi, Prasojo; Kusuma, Tiara Mega; Muhlisin, Zaenul; Nur, Muhammad; Nurani, Laela Hayu; Santosa, Budi; Ishijima, Tatsuo; Nakatani, Toshio

doi:10.1016/j.cpme.2017.03.001

Cited by 14 publications

(17 citation statements)

References 33 publications

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“…A complimentary report applied oil to the wound first, followed by Ar/air or Ar/O 2 plasma jet treatment, also reporting positive results [ 73 ]. In contrast, the combination of gas plasma jet wound treatment and medical honey did not lead to beneficial healing effects [ 62 , 63 ].…”

Section: Gas Plasma Treatment Of Skin and Wounds In Animal And Veterinary Modelsmentioning

confidence: 99%

Gas Plasma-Augmented Wound Healing in Animal Models and Veterinary Medicine

2021

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The loss of skin integrity is inevitable in life. Wound healing is a necessary sequence of events to reconstitute the body’s integrity against potentially harmful environmental agents and restore homeostasis. Attempts to improve cutaneous wound healing are therefore as old as humanity itself. Furthermore, nowadays, targeting defective wound healing is of utmost importance in an aging society with underlying diseases such as diabetes and vascular insufficiencies being on the rise. Because chronic wounds’ etiology and specific traits differ, there is widespread polypragmasia in targeting non-healing conditions. Reactive oxygen and nitrogen species (ROS/RNS) are an overarching theme accompanying wound healing and its biological stages. ROS are signaling agents generated by phagocytes to inactivate pathogens. Although ROS/RNS’s central role in the biology of wound healing has long been appreciated, it was only until the recent decade that these agents were explicitly used to target defective wound healing using gas plasma technology. Gas plasma is a physical state of matter and is a partially ionized gas operated at body temperature which generates a plethora of ROS/RNS simultaneously in a spatiotemporally controlled manner. Animal models of wound healing have been vital in driving the development of these wound healing-promoting technologies, and this review summarizes the current knowledge and identifies open ends derived from in vivo wound models under gas plasma therapy. While gas plasma-assisted wound healing in humans has become well established in Europe, veterinary medicine is an emerging field with great potential to improve the lives of suffering animals.

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Section: Gas Plasma Treatment Of Skin and Wounds In Animal And Veterinary Modelsmentioning

confidence: 99%

Gas Plasma-Augmented Wound Healing in Animal Models and Veterinary Medicine

2021

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“…Beberapa penelitian yang terkait dengan plasma medicine yang dilakukan oleh para peneliti di berbagai negara, memperlihatkan potensi yang sangat besar dalam penerapan disiplin ilmu ini dalam dunia dunia kesehatan. Beberapa penelitian dalam bidang plasma medicine, antara lain adalah pemanfaatan plasma dapat membasmi mikroorganisme pada luka kronis sekaligus penyembuhan pada kanker [3,4], dan perawatan luka pada binatang tikus yang memadukan penggunaan plasma dengan madu [5]. Sampai saat ini tahapan pengembangan plasma medicine masih dalam tataran penelitian yang berfokus pada penyempurnaan disain alat agar sempurna dan lebih aman digunakan untuk kulit manusia [6].…”

Section: Pendahuluanunclassified

Perancangan dan Pembuatan Prototipe Robot sebagai Penggerak Ujung Peralatan Plasma Medicine untuk Perawatan Luka

Wirawan

2020

emitor

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Plasma medicine adalah kajian baru yang bersifat multidisiplin yang berupaya menerapkan teknologi plasma untuk terapi kesehatan, seperti perawatan luka dan penyembuhan kanker. Pada saat ini plasma medicine penggunaanya masih berbasis manual yang pengoperasiannya mempunyai resiko tinggi pada manusia sebagai operator mesin. Penelitian ini bertujuan untuk merancang sebuah alat yang mampu menggerakan plasma medicine secara otomoatis dengan pengendali jarak jauh untuk mengurangi resiko kecelakaan kelistrikan pada operator manusia. Alat ini menggunakan konsep pada mesin cnc, drawing machine, dan axidraw yang di gerakan dengan 2 motor stepper nema 17 dan dikendalikan oleh komputer melalui arduino uno, lalu plasma medicine ditempatkan pada ujung alat ini. Diharapkan plasma medicine dapat digerakan secara leluasa dan menghasilkan hasil yang lebih optimal.

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“…10,11 However, the contact style of plasma jet treatment (the plasma condition) has a destructive effect on normal mouse skin. 11,12 Abnormal epidermal tissue in skin wounds was found to be due to the contact style of plasma jet treatment. 13 However, applying plasma jet treatment in the contact style may effectively eradicate chronic wound-related bacteria.…”

Section: Introductionmentioning

confidence: 99%

Accelerated Healing of Chronic Wounds under a Combinatorial Therapeutic Regimen Based on Cold Atmospheric Plasma Jet Using Contact and Noncontact Styles

et al. 2021

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One critical element for applying atmospheric pressure plasma jet for medical purposes is that it is possible to construct a combinatorial therapeutic regimen based on contact and noncontact styles for the cold atmospheric plasma jet. This study evaluates plasma jet effectiveness for bacteria-infected wounds in a small animal model. In this investigation, we test a novel combinative treatment using contact and noncontact style for plasma jet that was generated at high voltage of ~ 9 kV. We use medical-grade argon gas as a single carrier gas. The object of plasma treatment is BALB/c mouse skin wounds that were infected with Staphylococcus aureus. We use four plasma jet treatments, namely, C (control), CP-CP (contact), NCP-NCP (noncontact), and CP-NCP (contact-noncontact). For CP-NCP, from days 0 to 7 we apply a contact style of plasma jet treatment to wounds to kill bacteria; from days 8 to 13, a noncontact style of plasma jet is applied to stimulate wound healing. Our results show that with CP-CP, contact plasma treatment can remove the biofilm layer, but after the biofilm layer disappears contact plasma treatment inhibits the wound-healing process. NCP-NCP is not effective in eliminating bacterial biofilms and impedes the wound-healing process. With CP-NCP, contact plasma exposure during days 0 to 7 is able to remove bacterial biofilms, and irradiation of noncontact plasma during days 8 to 14 accelerates wound healing. Finally, CP-NCP significantly accelerates healing. The combinatorial therapeutic regimen based on contact and noncontact styles of cold atmospheric plasma jet is recommended for chronic wound management, because it effectively removes bacterial biofilms and accelerates wound healing.

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Evaluation the effectiveness of combinative treatment of cold plasma jet, Indonesian honey, and micro-well dressing to accelerate wound healing

Cited by 14 publications

References 33 publications

Gas Plasma-Augmented Wound Healing in Animal Models and Veterinary Medicine

Gas Plasma-Augmented Wound Healing in Animal Models and Veterinary Medicine

Perancangan dan Pembuatan Prototipe Robot sebagai Penggerak Ujung Peralatan Plasma Medicine untuk Perawatan Luka

Accelerated Healing of Chronic Wounds under a Combinatorial Therapeutic Regimen Based on Cold Atmospheric Plasma Jet Using Contact and Noncontact Styles

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