Epidermal Changes Associated with Sclerosing Hemangiomas

Phenotypic characterization of human keratinocytes in coculture reveals differential effects of fibroblasts from benign fibrous histiocytoma (dermatofibroma) as compared to cells from its malignant form and to normal fibroblasts

“…Although the marked hyperplasia of epidermis overlying BFH is well known as morphological feature and used in diagnostic procedures [3][4][5][6][7][8], the mechanisms underlying this phenomenon are yet to be defined. Rather likely, stromal fibroblasts may play a role in this cascade of processes, because fibroblasts prepared from both basal and squamous cell carcinoma, respectively, are able to significantly influence the phenotype of keratinocytes in coculture [16,17].…”

“…Changes of the epidermis in contact with the tumor represent a characteristic diagnostic feature of this type of neoplasia. The epidermal morphology varies from simple acanthosis to pronounced basaloid hyperplasia, very similar in appearance to cell clusters in basal cell carcinoma [3][4][5][6][7]. Immunohistochemical analysis of the epidermis overlying the center of the dermatofibroma revealed distinct changes in proliferation and level of differentiation [8].…”

Basal cell carcinomatous changes on the lower leg: a possible association with chronic venous stasis

“…It is our view this dermal influence in the form of chronic venous stasis may induce the irregular epidermal hyperplasia and rete ridge proliferation. Such epidermal changes are not at all disimilar from those occasionally encountered overlying histiocytomas (Halpryn & Allen 1959, Caron & Clink 1964, Thies & Hennies 1968, in which the dermal influence presumably induces the epidermal hyperplasia and later in a minority frank BCC changes.…”

Basal Cell Carcinoma Occurring in Association with Dermatofibroma

“…Furthermore there seems to be no consensus on how to make the distinc tion between a BCC and a 'BCC-Iike change'. Halpryn and Allen [3] reported 8% of dermatofibromata to show changes of BCC. Schoenfekl (4) however studied 457 der matofibromata and, whilst describing basaloid hyperplasia in over 5%, viewed the changes to be entirely benign.…”

“…BCC overlying a dermatofibroma is an uncommon finding [5][6][7][8][9][10][11][12][13]. Controversy exists whether changes of a BCC overlying a dermatofibroma are neoplastic [3] or reactive [4] in origin.…”