Basal Cell Carcinoma Occurring in Association with Dermatofibroma

McKenna, K.F.; Somerville, Jennifer; Walsh, Maureen; Dawson, J.F.; Burrows, D.

doi:10.1159/000247199

Cited by 13 publications

(5 citation statements)

References 9 publications

(10 reference statements)

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“…24,25,28,,29,30 In contrast, the occurrence of BCC over DF is extremely rare, with few supporting case reports. [31][32][33][34][35][36][37] Distinction between FI and BCC can be challenging in superficial biopsies, in which the DF is not directly visualized (Table). Both BCC and FI show peripheral palisading 24 and a superficial, budlike growth pattern (Figure 2, A through C).…”

Section: Follicular Induction Over Dermatofibromamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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Section: Follicular Induction Over Dermatofibromamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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“…Basaloid proliferations overlying dermatofibromas may occur and these range from basal cell hyperplasia with follicular differentiation to well-developed basal cell carcinomas. [7][8][9][10][11] Melanocytic proliferations occurring in association with dermatofibromas have been less well documented in the literature. In a report of three cases, Toda et al 12 described three cases of lentiginous melanocytic hyperplasia overlying dermatofibromas and there was an increased frequency of S-100 protein and Mel-5 melanocytes along the basal layer of the epidermis overlying dermatofibromas.…”

Section: Histologic Findingsmentioning

confidence: 99%

Melanocytic lesions associated with dermatofibromas: a spectrum of lesions ranging from junctional nevus to malignant melanoma in situ

2005

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Dermatofibromas are common lesions that are often associated with epidermal hyperplasia and basal layer hyperpigmentation. A single case of lentiginous melanocytic hyperplasia overlying a dermatofibroma has been reported, however, nevi and melanoma have to the best of our knowledge, not been previously reported. We present 14 cases of melanocytic lesions associated with dermatofibromas. The clinical data and hematoxylinand eosin-stained sections were obtained and formalin-fixed, paraffin-embedded tissue was immunostained with antibodies against S-100, Mart-1, Factor XIIIa, and CD117. There were nine females and five males ranging in age from 30 to 64 years and anatomic sites included back (five), arm (six), flank (two), and leg (one). The clinical diagnosis ranged from dermatofibroma to desmoplastic melanoma. Histologically, the melanocytic lesions included junctional, compound, and dermal nevi, and malignant melanoma in situ. In four cases the dermal component appeared to merge with the dermatofibroma. In the case of the melanoma in situ, the dermatofibroma abutted the epidermis. Immunohistochemically, the melanocytic lesions were S-100/ Mart-1 þ , FXIIIa-, and the dermatofibromas were S-100/Mart-1À, FXIIIa þ . Melanocytic neoplasia may appear in association with dermatofibromas. The fibrohistiocytic proliferation may be misinterpreted as a spindle or pleomorphic melanocytic process. Awareness of this association will aid in the correct diagnosis, and immunohistochemical studies will help in the differentiation of these two cell populations.

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“…This association is very unusual. Boyd and Rapini 1 did not find it in their series, although it has been reported in the literature 1,10 . We believe that it represents the presence of two more common lesions juxtaposed by coincidence.…”

Section: Discussionmentioning

confidence: 66%

“…Boyd and Rapini 1 did not find it in their series, although it has been reported in the literature. 1,10 We believe that it represents the presence of two more common lesions juxtaposed by coincidence. Dermatofibromas are usually easy to identify clinically as firm cutaneous nodules.…”

Section: Discussionmentioning

confidence: 96%

Dermoscopy is useful for the recognition of benign-malignant compound tumours

Zaballos

Llambrich

Puig

et al. 2005

British Journal of Dermatology

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The association of two different neoplasms in the same lesion is uncommon and has been reported as collision or compound tumours in the medical literature. In cases where a malignant neoplasm exists in association with a benign lesion it is important to make an accurate diagnosis in order to treat the lesions correctly. Dermoscopy is an in vivo, noninvasive technique that improves the clinical accuracy in diagnosing melanoma and other pigmented skin lesions. We describe the dermoscopic characteristics of various collision or compound tumours that were composed of benign and malignant neoplasms: two cases of seborrhoeic keratosis associated with basal cell carcinoma, two cases of melanocytic naevus and basal cell carcinoma and one case of dermatofibroma associated with basal cell carcinoma. We conclude that dermoscopy is a useful tool for improving the recognition of these kinds of tumours.

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Basal Cell Carcinoma Occurring in Association with Dermatofibroma

Cited by 13 publications

References 9 publications

Histologic Mimics of Basal Cell Carcinoma

Histologic Mimics of Basal Cell Carcinoma

Melanocytic lesions associated with dermatofibromas: a spectrum of lesions ranging from junctional nevus to malignant melanoma in situ

Dermoscopy is useful for the recognition of benign-malignant compound tumours

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