Taken together with previous findings, these results support the notion that genetic susceptibility factors responsible for common, subsyndromal social impairments may be related to the causes of categorically defined pervasive developmental disorders.

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An ongoing study of the phenomenology, genetics, neuropsychology, physiology (eye tracking, autonomic responsivity), neuroimaging, biochemistry, and pharmacology of childhood-onset schizophrenia is described, and pilot data are presented for the first 22 subjects. Differentiation from autism "spectrum" disorders and other poorly defined, severe neurodevelopmental disorders is needed. Eye tracking and autonomic results are similar to patterns seen in later-onset schizophrenia and possibly more striking. Magnetic resonance imaging showed larger left frontal ventricular horn area for the schizophrenia subjects, larger left caudate, and lack of normal caudate asymmetry. Fluorodeoxyglucose positron emission tomography during an auditory continuous performance task revealed decreased right parietal/occipital glucose metabolic rate in the schizophrenia subjects, which may be secondary to poor attentional performance, and increased glucose metabolic rate in three left frontal regions, a left parietal region, and the right putamen. Clozapine has been effective and well tolerated in an open trial with 12 adolescents who responded poorly to typical neuroleptics; 16 subjects have been enrolled in a double-blind comparison of haloperidol and clozapine. Longitudinal study of this narrowly defined and possibly more homogeneous group of very early-onset schizophrenia subjects will be relevant to current neurodevelopmental theories addressing the role of puberty, progression of pathology, and continuity or discontinuity with later-onset schizophrenia.

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Brain anatomic abnormalities in childhood-onset schizophrenia are similar to those reported for adult populations, indicating overall continuity between these rare childhood cases and the adult schizophrenia populations.

The conjecture that magnetic helicity (linked flux) is conserved in magnetized plasmas for time scales that are short compared to the resistive diffusion time is experimentally tested in the CTX spheromak [Phys. Rev. Lett. 45, 1264 (1980); 51, 39 (1983); Nucl. Fusion 24, 267 (1984)]. Helicity is created electrostatically by current drawn from electrodes. The magnetized plasma then flows into a conducting flux conserver where the energy per helicity of the plasma is minimized and a spheromak is formed on a relaxation time scale of many Alfvén times. The magnetic field strength of the equilibrium is subsequently increased and sustained. The amount of helicity created by the magnetized coaxial plasma source, the helicity content of the spheromak equilibrium, and the resistive loss of the helicity are measured to determine the balance of helicity between source and spheromak with a ±16% uncertainty. In CTX the amount of energy that must be rapidly dissipated within the conducting boundary while conserving helicity in the process of sustaining the spheromak is experimentally controllable, and has varied from 1.8 times the spheromak magnetic energy to greater than 10 times. The relaxation, or minimization of the energy-to-helicity ratio, determines the gross structure (the normalized spatial profile) of the spheromak, while the conservation of helicity itself determines the magnitude and time dependence of the magnetic fields of the spheromak equilibrium. Helicity balance tests are done by individually varying the sign and magnitude of the source voltage and flux, and by observing sustainment of spheromaks with fields opposing those of the source. A threshold for helicity injection from the source is measured and related to the source and entrance region size. During times short compared to resistive diffusion time scales the helicity is shown to be conserved with a ±12% uncertainty using no free parameters. For longer times the resistive dissipation Its value is independently measured and appears to be related to the expected classical resistive decay. Absolutely calibrated bolometer measurements are consistent with excess source energy heating the spheromak plasma during the sustainment by electrostatic helicity injection.

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