Basal cell carcinomatous changes on the lower leg: a possible association with chronic venous stasis

Abstract

Twenty-one patients are reported who developed basal cell carcinomas on the lower leg. The commonest presentation was of a chronic 'stasis' ulcer which usually occurred at atypical sites. It is suggested that the development of basal cell carcinoma changes on the lower leg is a not infrequent complication of chronic venous stasis.

Frequency of Malignant Neoplasms in 257 Chronic Leg Ulcers

“…They represented approximately 4% (10/276) of the total patients of our series. Some authors have considered CLU to be a precancerous condition, but others have found the association between CLU and malignant skin cancer to be merely coincidental …”

Chronic Venous Stasis: Not a Predisposing Factor for Basal Cell Carcinoma on the Leg

“…A number of conditions may favor the development of BCC: several congenital or genetic entities (nevus scbaceus [10,11], nevoid BCC syndrome [12], linear unilateral basal cell nevus [13], Bazex's syndrome [ 14] and xeroderma pig mentosum [15]); BCC can also be observed overlying a der matofibroma [16]; numerous environmental or extrinsic factors such as prolonged sun exposure in white persons, xray irradiation, arsenic, chemical carcinogens or scars arc implicated in the development of BCC [17][18][19], In addi tion, some authors have suggested that BCC on the leg is not an infrequent complication of chronic venous stasis [4][5][6][7][8][9]. Black and Walkdcn [6] postulated that the dermal 92 Aloi/Tomasini/Margiotta/Pippione Basal Cell Carcinoma and Stasis Changes changes in chronic venous stasis may induce irregular basaloid hyperplasia of the overlying epidermis, which (as the exceedingly rare BCC overlying in long-standing dermato fibromas) would eventuate in a true BCC. In contrast to previous reports [4][5][6][7][8][9] our scries demon strates that chronic venous stasis does not represent a pre disposing factor to the development of BCC of the leg.…”

“…Black and Walkdcn [6] postulated that the dermal 92 Aloi/Tomasini/Margiotta/Pippione Basal Cell Carcinoma and Stasis Changes changes in chronic venous stasis may induce irregular basaloid hyperplasia of the overlying epidermis, which (as the exceedingly rare BCC overlying in long-standing dermato fibromas) would eventuate in a true BCC. In contrast to previous reports [4][5][6][7][8][9] our scries demon strates that chronic venous stasis does not represent a pre disposing factor to the development of BCC of the leg. In fact, although stasis changes are a common finding in old people [9,20], they have been found in association with BCC of the leg only in 25% of our cases.…”

“…It usu ally occurs on sun-exposed areas, especially on the head and neck but can be observed anywhere. The leg is an infrequent site of BCC; its incidence at this site in Japanese women is three times as great as in men [3], Venous chronic stasis has been considered as a predisposing factor for the development of BCC on the legs [4][5][6][7][8][9], In the present study, we have histologically reviewed BCC on the leg, with the following aims: (i) to define histological patterns and (ii) to assess the correlation, if any. between BCC on the leg and chronic venous stasis.…”

Diagnostische Falle: ein Basalzellkarzinom unter dem Bild eines therapieresistenten Ulcus cruris

“…0,2% geschätzt [2]. Eine mögliche Assoziation mit einer chronisch-venösen Stase wird diskutiert [1]. Inwieweit diese Koexistenz von chronisch-venösen Ulzerationen und Basalzellkarzinomen kausal relevant ist, ist fraglich.…”