Effect of Helicobacter pylori eradication therapy in rosacea patients

Abstract

Objective: the causal relation between rosacea and Helicobacter pylori infection is discussed. We evaluated the clinical evolution of rosacea after infection eradication.Patients and methods: we have prospectively studied 44 patients diagnosed with rosacea. Helicobacter pylori infection was determined, and infected patients were treated with eradication therapy. The evolution of dermatological symptoms in a subgroup of 29 infected patients in whom eradication had been achieved was followed during 16.8 (± 17.8) months. Median age was 50.6 (± 14.1) years for 22 women (75.9%) and 7 men (24.1%). Clinical response according to gender and clinical subtype of rosacea was evaluated.Results: complete improvement was observed in 10 patients (34.5%; 95% CI: 18.6-54.3%), relevant improvement in 9 (31.1%; 95% CI: 16-51%), poor improvement in 5 (17.2%; 95% CI: 6.5-36.4%), and absence of improvement in 5 cases (17.2%; 95% CI: 6.5-36.4%). No significant differences in dermatological evolution according to sex were observed. Regarding subtype of rosacea there was a relevant improvement in 83.3% (95% CI: 64.1-93.8%) of cases with papulopustular type as opposed to 36.5% (95% CI: 20-56.1%) of cases with erythematous predominance, p = 0.02.Conclusions: based on these results, the relation between Helicobacter pylori and rosacea is supported, and infection should be investigated in these patients because an appreciable percentage of patients diagnosed with rosacea and Helicobacter pylori infection can benefit from eradication therapy, mainly in the papulopustular subtype.

Alopecia areata is not associated with Helicobacter pylori

“…[11] In addition to their direct injury to target tissues, infectious agents might exert their deleterious effects indirectly by interfering with the immune system. [8]…”

“…have published two articles showing that the seroprevalence of H. pylori is significantly higher in patients with insulin-dependent diabetes mellitus[4] and autoimmune atrophic thyroiditis. [8] They express the hypothesis that H. pylori antigens might be involved in the development of these two autoimmune diseases or that autoimmune function in these diseases may increase the likelihood of an H. pylori infection. On the basis of these studies and considering the fact that AA is a disease of unknown origin, we tried to determine whether there might be an association of H. pylori infection with AA.…”

“…In addition to their direct injury to target tissues, infectious agents might exert their deleterious effects indirectly by interfering with the immune system. [7] This bacterium has been associated with certain extra-digestive dermatological conditions, including chronic urticaria, rosacea,[8] Henoch-Schönlein purpura, Sweet syndrome, systemic sclerosis, and atopic dermatitis. [3]…”

The Study of Prevalence of Helicobacter Pylori in Patients with Acne Rosacea

“…[13][14][15][16][17][18][19][20] Others comment on the beneficial effect of H. pylori eradication in rosacea. 15,17,[21][22][23][24] Some other investigators contradict any associations between rosacea and H. pylori infection. [25][26][27][28] Based on the different studies to date Lazaridou et al later concluded that due to the high prevalence of anti-Hp antibodies in humans in conjunction with the fact that the antibiotics are effective for both disease entities, it would be very difficult to stratify the population studied against all factors that influence both rosacea and H. pylori infection.…”

Rosacea: modern aspects of the etiology and pathogenesis

“…Особое внимание уделяется роли Helicobacter pylori [51][52][53]. Cвязь H. pylori и розацеа была доказана в исследовании 29 больных розацеа в 1996-2001 гг., которые получали антихеликобактерную терапию.…”